• Correlation of clinic and paraclinic bronchial asthma symptoms with the level of serum thymic stromal lymphopoietin in children

Correlation of clinic and paraclinic bronchial asthma symptoms with the level of serum thymic stromal lymphopoietin in children

SOVREMENNAYA PEDIATRIYA.2018.7(95):20-26; doi 10.15574/SP.2018.95.20

Klymenko V. A., Kozhyna O. S.
Kharkiv National Medical University, Ukraine

Object. Define the amount of thymic stromal lymphopoietin (TSLP) in bronchial asthma (BA) pathogenesis in children by detecting the effect of TSLP on clinic and paraclinic symptoms of BA manifestation.

Methods and Materials. 70 children aged 6–17 years old were observed. The control group consisted of 20 healthy children, randomized by age. Standard methods of examination in accordance with the unified clinical protocol «Bronchial Asthma in Children» (order of the Ministry of Healthcare of Ukraine on 08.10.2013, No 868) were applied. The TSLP level was defined in remission period by the immunoenzyme method.

Results. The reference levels of serum TSLP (19.39 (6.13; 49.52) pg/ml) and levels of TSLP depending on severity of BA were determined: intermittent form — 12.44 (6.42; 17.21) pg/ml; mild persistent form — 5.95 (4.50; 15.57) pg/ml; moderate persistent form — 10.67 (4.68; 21.20) pg/ml; severe persistent form — 81.84 (62.60; 98.9) pg/ml. When analyzing the effect of TSLP level on clinical features of BA (term of manifestation, duration of BA, presence of atopy, comorbid state of atopic dermatitis and allergic rhinitis, allergic and BA inheritance were explored), only probable difference for hereditary tainted allergy (P=0.027) was revealed. Analysis of TSLP level correlation with paraclinic criteria revealed probable correlation connections of TSLP level with FEV1 (r=-0.213; Р=0.039), absolute lymphocyte CD8 count (r=-0.254; Р=0.034), absolute lymphocyte CD25 count (r=-0.248; Р=0.038); NBT test stimulated (r=0.250; Р=0.037).

Conclusions. TSLP level in blood serum in schoolDaged children suffering from BA is probably higher in the case of severe disease and due to hereditary tainted allergy, correlates with FEV1, lymphocyte CD8 count, lymphocyte CD25 count and NBT test.

Key words: children, bronchial asthma, pathogenesis, clinic and paraclinic symptoms, serum thymic stromal lymphopoietin.


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Article received: May 21, 2018. Accepted for publication: Oct 30, 2018.