- Correction of iron deficiency in pregnant women with congenital heart defects, heart failure and anaemia
Correction of iron deficiency in pregnant women with congenital heart defects, heart failure and anaemia
PERINATOLOGY AND PEDIATRIC. UKRAINE. 2018.3(75):31-34; doi 10.15574/PP.2018.75.31
Ogorodnyk A. O., Limanskaya А. Yu., Butenko L. P., Davydova Iu. V.
SI Institute of Pediatrics, Obstetrics and Gynecology named after academician O. Lukyanova of the National Academy of Medical Sciences of Ukraine, Kyiv
Objective: to improve treatment of iron deficiency anaemia in pregnant women of high cardiac risk.
Materials and methods. The study included 73 pregnant women with congenital heart defects (CHD) associated with heart failure (HF) and anaemia. When the haemoglobin level was above 95 g/L and the estimated delivery date more than 40 days from the treatment onset, the oral iron (II) preparations were administered to pregnant women. When the haemoglobin level was below 95 g/L, in order to correct anaemia, the iron sucrose was administered in parenteral solution in the event of abdominal delivery suggested with the succeeding transition to the oral iron (II) preparations before and after delivery.
Results. The use of a stepwise treatment regimen with intravenous and oral iron preparations contributed to the iron depot normalization, in contrast to the exclusively oral iron preparations administration, and stabilizing the condition of women as well as. All pregnants who received treatment according to the developed algorithm did not have the perinatal losses, childbirth in term less than 28 gestation weeks or Apgar score lower than 5 points at birth.
Conclusions. Stabilization of pregnant women's condition with CHD, HF and anaemia due to the lack of HF progression, normalization of iron metabolism and avoidance of obstetric complications and perinatal losses prove the efficacy of stepwise antianaemic therapy using the intravenous iron and oral iron (Fe II) in pregnant women of high cardiac risk.
Key words: pregnancy, congenital heart defects, anaemia, heart failure.
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Article received: Jul 18, 2018. Accepted for publication: Sep 12, 2018.