• Contribution of natural auto-IgM in congenital immunity

Contribution of natural auto-IgM in congenital immunity

PERINATOLOGY AND PEDIATRIC. UKRAINE. 2018.2(74):45-51; doi 10.15574/PP.2018.74.45

Makarenko M. V., Govsieiev D. О., Sokol I. V., Berestoviy V. O., Martych A. M., Vorona R. M.
Bogomolets National Medical University, Kyiv, Ukraine

Natural auto-IgM are synthesized in B1-cells (CD5+ mice, CD20+CD27+CD43+CD70 — in humans) and play a significant role in protecting the body from the invasion of antigens of different genesis, maintain the immunochemical homeostasis of the organism, regulate the clearance of apoptotic cells, perform anti-inflammatory function, regulate autoreactive antibodies and remove proteins with unfinished or defective folding. These observations became the impetus for finding ways of therapeutic use of natural auto-IgM, increasing their amount of in vivo, and the use of monoclonal and polyclonal IgM preparations.
Key words: natural auto-IgM antibodies, immunity, B1-cells.


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