• Congenital malformations in children born using assisted reproductive technologies 
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Congenital malformations in children born using assisted reproductive technologies 

SOVREMENNAYA PEDIATRIYA.2016.8(80):45-48; doi 10.15574/SP.2016.80.45 

Congenital malformations in children born using assisted reproductive technologies 

Stoieva T. V., Synenko V. V., Strechen E. A.

Odessa National Medical University, Ukraine

Objective — to determine the frequency and structure of congenital malformations in children born as a result of induced pregnancy.

Patients and methods. To achieve the goal were examined 74 children who was born with the help of reproductive technology (ICSI technique).

Results. The frequency of malformations in examined children was 24.3%. The cardiovascular malformations, urinary and digestive systems, as well as the abnormal of musculoskeletal system and sensory organs are defined in this structure. The proportion of big defects was 27.8%, small anomalies of development — 72.2%. Analysis of the anamnestic factors importance of demonstrated the presence of association of malformations occurrence and somatic (χ2=8.4, p=0.004) and reproductive (χ2=14.45, p=0.0001), health mothers of children examined.

Conclusions. The analysis showed a high incidence of congenital malformations in children born as a result of induced pregnancy. In the structure of registered prevalence of small anomalies (p<0.001) on the appearance of which is significantly affected by health of mothers.

Key words: children, ART (ICSI), congenital malformations.


1. Tokova ZZ, Korneeva IЕ, Medvedeva ЕN et al. 2013.Gynecological history of women admitted for treatment in the program of assisted reproductive technology. Ginekologiya. 15(5): 56-58.

2. Rimm A, Katayama A, Diaz M, Katayama K. 2004. A meta-analysis of controlled studies comparing major malformation rates in IVF and ICSI infants with naturally conceived children. J Assist Reprod Genet. 21: 437—439. https://doi.org/10.1007/s10815-004-8760-8; PMid:15704519 PMCid:PMC3455612

3. Zwink N, Jenetzky E, Schmiedeke E et al. 2012. Assisted reproductive techniques and the risk of anorectal malformations: a German casecontrol study. Orphanet Journal of Rare Diseases. 7: 65. https://doi.org/10.1186/1750-1172-7-65; Mid:22978793 PMCid:PMC3519554

4. Davies MJ, Moore VM, Willson KJ. 2012. Reproductive technologies and the risk of birth defects. N Engl J Med. 19: 1803—1813. https://doi.org/10.1056/NEJMoa1008095; PMid:22559061

5. Cai QF. 2011. Factors predicting the cumulative outcome of IVF/ICSI treatment: a multivariable analysis of 2450 patients. Hum Reprod. 26; 9: 2352—2540. https://doi.org/10.1093/humrep/der228; PMid:21771773

6. Finnstrom O, Kallen B, Lindam A et al. 2011. Maternal and child outcome after in vitro fertilization — a review of 25 years population based data from Sweden. Acta Obstet Gynecol Scand. 90(5): 494—500. https://doi.org/10.1111/j.1600-0412.2011.01088.x; PMid:21306346

7. Obstetric and perinatal outcomes in singleton pregnnancies resulting from IVF/ ICSI: a systematic review and metaanalysis / S. Pandey, A. Shetty, M. Hamilton [et al.] // Hum Reprod Update. — 2012. — № 18 (5). — P. 485—503.

8. Anteby I, Cohen E, Anteby E, BenEzra D. 2001. Ocular manifestations in children born after in vitro fertilization. Arch Ophthal. 119(10): 1525—1529. https://doi.org/10.1001/archopht.119.10.1525; PMid:11594955

9. Zhu J, Hvidtjшrn D, Basso O et al. 2010. Parental infertility and cerebralpalsy in children. Human Reproduction. 25; 12: 3142—3145. https://doi.org/10.1093/humrep/deq206; PMid:21045245 PMCid:PMC2989872

10. Tararbit K, Lelong N, Thieulin A et al. 2013. The risk for four specific congenital heart defects associated with assisted reproductive techniques: a population-based evaluation. Human Reproduction. 28: 367—374. https://doi.org/10.1093/humrep/des400; PMid:23178272 PMCid:PMC3874677

11. Wen J, Jiang J, Ding C. 2012. Birth defects in children conceived by in vitro fertilization and in tracytoplasmic sperm injection: a meta-analysis. Fertil Steril. 97(6): 1331—1337. https://doi.org/10.1016/j.fertnstert.2012.02.053; PMid:22480819