• Congenital adrenal hyperplasia in children due to 21-hydroxylase deficiency: clinical features, complications and approaches to their correction 
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Congenital adrenal hyperplasia in children due to 21-hydroxylase deficiency: clinical features, complications and approaches to their correction 

SOVREMENNAYA PEDIATRIYA.2015.4(68):123-127; doi 10.15574/SP.2015.68.123 
 

Congenital adrenal hyperplasia in children due to 21-hydroxylase deficiency: clinical features, complications and approaches to their correction 
 

Zelinska N., Pogadaeva N., Globa E., Shevchenko I.

Ukrainian Scientific and Practical Center of Endocrine Surgery, Transplantation of endocrine organs and tissues of the Ministry of Health of Ukraine, Kiev

Natsion Children's Specialized Hospital «Okhmatdet», Kiev 
 

In patients with congenital adrenal hyperplasia (CAH) with chronical hormonal decompensation may develop such complications as progression of virilization with an early closure of growth zones, infertility, the appearance of testicular adrenal rest tumors in boys, which can be cured with the normalization of hormonal status. The majority of girls (63%) have the III and IV stage of virilization of Prader scale. Corrective clitoroplasty was held in Ukraine only in 43% of girls with CAH. The approach to the pathogenetic treatment of patients with CAH with karyotype 46, XX, who are chosen to be brought up as a male must be individualized. 
 

Key words: congenital adrenal hyperplasia, children, hormone compencation, virilization, testicular adrenal rest testicular tumors. 
 

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