• Clostridium difficile infection in children and adults as a important reason of antibiotic associated diarrhea
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Clostridium difficile infection in children and adults as a important reason of antibiotic associated diarrhea

Modern Pediatrics.Ukraine.2020.3(107):59-66; doi 10.15574/SP.2020.107.59
Romankevych I. V.
Shupyk National Medical Academy of Postgraduate Education, Kуiv, Ukraine
Dr. Rodger Laboratory Clinic, Kyiv, Ukraine

For citation: Romankevych IV. (2020). Clostridium difficile infection in children and adults as a important reason of antibiotic associated diarrhea. Modern Pediatrics. Ukraine. 3(107): 5966; doi 10.15574/SP.2020.107.59
Article received: Nov 03, 2019. Accepted for publication: Apr 15, 2020.

Antibiotic-associated diarrhea is a major medical problem worldwide. C. difficile is the most dangerous cause, the overgrowingn of which with the enteropathogenic toxin release is observed as a result of depletion of an intestinal microbiota, after antibiotics using. Despite an active researching of C. difficile (CDI) infection in Western countries, it diagnostics and treatment in Ukraine are underdeveloped.
The aim of this article is to familiarize a wide range of physicians of various specialties with the specifics of the epidemiology, clinic, diagnosis and treatment of CDI as the most dangerous form of antibiotic-associated diarrhea.
The article highlights the risk factors for the development of CDI, the main aspects of the clinical picture, the two- and three-stage diagnostic algorithms and peculiarities of infection treatment and its relapse in adults and children.
No conflict of interest was declared by the author.
Key words: C. difficile, toxin, diarrhea, NAAT, ELISA for GDH antigen detection, Vancomycin, Fidoximycin.


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