- Clinical significance of phospholipid levels in exhaled breath condensate in children with wheezing
Clinical significance of phospholipid levels in exhaled breath condensate in children with wheezing
SOVREMENNAYA PEDIATRIYA.2018.4(92):22-26; doi 10.15574/SP.2018.92.22
Makieieva N., Malakhova V.
Kharkiv National Medical University, Ukraine
Wheezing is a combination of clinical symptoms with a violation of the passage of air through the bronchi. The first episode of wheezing is recorded in about 30% of children in the first year. The formation of respiratory allergies most often takes its beginning in early childhood. All over the world, they relate to almost 700 million cases and about 330 million of them are bronchial asthma.
Objective. The objective of this study was to assess the levels of phospholipids in exhaled breath condensate (EBC) in children with recurrentepisode of wheezing.
Material and Methods. The objective of this study was to assess the levels of phospholipids in exhaled breath condensate in children.70 patients from 1 to 7 years withrecurrent episode of wheezing and bronchial asthma. The levels of phospholipids in EBC were studied by chromatography, using a spectrophotometer SF-46. The levels of phospholipidswere taken at the beginning of the wheezing and at the onset of clinical remission.
Results. In patients of all groups there was an increase in the levels of phospholipids in EBC, in comparison with the control group. The increase in the levels was noted both at the onset of the disease and at the achievement of clinical remission. The highest levels of phospholipids in EBC were in children with asthma and in children who had more episodes of wheezing.
Conclusions.The study of the levels of OPL in CVI provides additional information on the state of the bronchopulmonary system and the degree of damage to cell membranes. This can be used to predict the progression of inflammation in the bronchopulmonary system.
Keywords: wheezing, bronchial asthma, children, exhaled breath condensate, phospholipids.
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