• Clinical manifestations of food allergy and calcium-phosphorus ensure young children
To content

Clinical manifestations of food allergy and calcium-phosphorus ensure young children

SOVREMENNAYA PEDIATRIYA.2015.7(71):107-110; doi 10.15574/SP.2015.71.107 

Clinical manifestations of food allergy and calcium-phosphorus ensure young children 

Kryazhev A. V., Ovcharenko L. S., Vertegel A. A., Samohin I. V., Andrienko T. H., Zhikhareva N. V.

GU «Zaporozhye Medical Academy of Postgraduate Education, Ministry of Health of Ukraine» 

Purpose. Installing the relationship between calcium-phosphorus indicators and provide clinical manifestations of food allergy (FA) in young children based on the correlation analysis of the relationship. 

Materials and Methods. Selected 150 children of food allergy in which established sensitization to cow's milk protein by examining the general and specific IgE in serum. The main symptoms of food allergy were atopic dermatitis (AD). Conducted determination of levels of total calcium, inorganic phosphorus, alkaline phosphatase, osteocalcin, parathyroid hormone and vitamin 25(OH)D3 in the serum of children as one of the markers of bone metabolism. In the future, established correlations between indicators of calcium-phosphorus software and manifestations of food allergy in infants. Formed two groups of observations: 1) the group — children with manifestations of FA and impaired calcium-phosphorus software (n=56); 2) II group — children with of FA manifestations without violations calcium-phosphorus software (n=94). 

Results. In 37% of children aged 1 to 3 years, on a background of food allergies are identified deviation parameters characterizing the process of bone formation (decreased total calcium concentration by 15.7% (р<0.05), inorganic phosphorus — 17.8% (р<0.05) increase in alkaline phosphatase activity by 89.8% (р<0.05) concentration of 4.4 times osteocalcin in serum (p<0.05)). The presence and activity of chronic allergic inflammation persists in children with food allergy is one of the causes of violations of osteogenesis processes, as evidenced by the direct and inverse correlations between factors of allergic inflammation (prevalence, dry skin, itching, peeling) and markers of bone formation (total calcium, inorganic phosphorus, alkaline phosphatase, parathormone, osteocalcin), (ρ=-0,884, -0,765, +0,884, -0,651, +0,803, respectively). Major factor contributing to the development of processes of bone formation disorders in children with food allergies, a high prevalence (kS> 40) allergic process in the skin, directly correlated with the depth of changes in the parameters of bone metabolism (ρ= +0,820). 

Conclusion. The presence of clinical manifestations of asthma dictates the need to identify markers of bone formation in children. Identified variations in the calcium-phosphorus need to ensure their correction, with basic therapy of AD. 

Key words: children, food allergies, calcium and phosphorus. 

REFERENCES

1. Васильева ТГ, Кочеткова ЕА, Антоненко ФФ. 2008. Ассоциация гена коллагена и рецептора витамина Д с остеопеническим синдромом при ювенильных артритах у детей. Педиатрия. 87; 5: 41—44.

2. Гнатейко ОЗ, Лук'яненко НС. 2007. Екогенетичні аспекти патології людини, спричиненої впливом шкідливих факторів зовнішнього середовища. Здоровье ребенка. 6(9): 82—87.

3. Протокол діагностики та лікування дітей з атопічним дерматитом. Додаток до наказу МОЗ України №767 від 27.12.2005 р. МОЗ України. Офіц. вид. Київ. 2005: 35.

4. Коваленко ВМ, Шуба НМ, Борткевич ОП та ін. 2009. Сучасні підходи до лікування остеопорозу з урахуванням відкриття нових механізмів його розвитку: метод. рекомендації. Київ: 31.

5. Тыртова ЛВ. Возрастные особенности костного метаболизма у детей и профилактика нарушений минерализации костной ткани. http://www.infran.ru/meetings/Thesis-visc.pdf.

6. Щеплягина ЛА, Римарчук ГВ. 2011. Костная прочность у детей: известные и неизвестные факты. Учеб пособие. Москва: 233.

7. Ferguson GT, Calverley PMA, Anderson JA et al. 2009. Prevalence and Progression of Osteoporosis in Patients With COPD. Results From TORCH. Chest. doi: 10.1378 / ch est. 08—3016.