• Clinical manifestation and fatty acid balance in children with biliary dysfunction and iron deficiency 
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Clinical manifestation and fatty acid balance in children with biliary dysfunction and iron deficiency 

PERINATOLOGIYA I PEDIATRIYA. 2016.2(66):116-121; doi 10.15574/PP.2016.66.116 

Clinical manifestation and fatty acid balance in children with biliary dysfunction and iron deficiency 

Marushko U. V., Nagorna K. I., Bryuzgina T. S.

Bogomolets National Medical University 

Objectives: to study the effect of iron deficiency (ID) on the clinical manifestation and erythrocytes, plasma and saliva fatty acids spectrum in children with functional disorders of the biliary tract (FDBT) 160 children 9–17 years old were examined who had been treated in hospital for FDBT exacerbation. According to the iron metabolism parameters children were divided into 3 groups: I — 29 children with FDBT and I-degree ID anemia; II — 91 children with FDBT and latent ID; III — 40 children with FDBT and normal iron metabolism tests.

Methods: the study of anamnesis, clinical examination, CBC, serum iron, TIBC indexes, percent transferrin saturation calculation, ultrasound of the abdomen and dynamic ultrasound cholecystography with choleretic breakfast, chromatographic analysis of erythrocytes, plasma and saliva fatty acid spectrum.

Results: it was found that ID children have an increase in the frequency and duration of FDBT

exacerbations, increased frequency of dyspeptic and asthenic-vegetative symptoms during exacerbation, decreased gallbladder motility and hypotonic-hypokinetic FDBT type. Changes in the erythrocytes, plasma and saliva fatty acid spectra were unidirectional in children with FDBT, and exhibited an increase in the fatty acid saturation. These changes were statistically significantly (p<0.05) more expressed in patients with ID.

Conclusion: Burdened course of FDBT is observed in children with ID due to increased frequency and duration of exacerbations, dyspeptic and asthenic-vegetative symptoms in the acute phase, minor bile ducts motility, as well as increased fatty acid spectra saturation in erythrocytes, plasma and mixed saliva, which indicates increased lipid peroxidation.

Key words: children, functional disorder of the biliary tract, iron deficiency, fatty acid spectrum, rythrocytes, plasma, saliva.


1. Ilchenko IA, Delyukina OV. 2011. Value biliary dysfunction in the pathogenesis of cholelithiasis. Eksperimentalnaya i klinicheskaya gastroenterologiya. 7: 70—78.. 2011.

2. Loranskaya ID. 2013. Functional disorders of the biliary tract. Moscow, Forte print: 92.

3. Smischuk V. 2015. Clinical and pathogenetic mechanisms of cholelithiasis in children and ways of prevention. extended abstract of Cand. Sci. dissert. 14.01.10. Kyiv: 22.

4. Unified clinical protocols of medical care for children with diseases of the digestive system. Order of Ministry of Health of Ukraine №59 from 29.01.2013. Sovremennaya pediatriya. 2013. 4: 20—31.

5. Shadrin OG, Hayduchyk GA. 2016. Problems of nutrition of infants and solutions. Ukrainian Medical Journal. 2(112); III/IV: 68—69.

6. Laass MW, Straub S. Chainey S et al. 2014. Effectiveness and safety of ferric carboxymaltose treatment in children and adolescents with inflammatory bowel disease and other gastrointestinal diseases. BMC Gastroenterol. 14: 184. http://dx.doi.org/10.1186/1471-230X-14-184. PMID:25326048

7. De Andrade Cairo RC, Rodrigues Silva L, Carneiro Bustani N, Ferreira Marques CD. 2014. Iron deficiency anemia in adolescents; a literature review. Nutr Hosp. 29(6): 1240—9. doi: 10.3305/6nh.2014.29.6.7245. Review.PMID:24972460

8. Bolsoni-Lopes A, Festuccia WT, Chimin P et al. 2014. Palmitoleic acid (n-7) increases white adipocytes GLUT4 content and glucose uptake in association with AMPK activation. Lipids Health Dis. 13: 199. http://dx.doi.org/10.1186/1476-511X-13-199.

9. Peluso I, Raguzzini A. 2016. Salivary and Urinary Total Antioxidant Capacity as Biomarkers of Oxidative Stress in Humans. Patholog Res Int. 2016: 5480267. http://dx.doi.org/10.1155/2016/5480267. Epub 2016 Feb 7. Review.PMID:26966611

10. Yokusoglu M, Nevruz O, Baysan O et al. 2007. The altered autonomic nervous system activity in iron deficiency anemia. Tohoku J Exp Med. 212(4): 397—402. PMID:17660705