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Clinical and biochemical features of the liver disease among children with Epstein-Barr virus infection

SOVREMENNAYA PEDIATRIYA. 2014. 5(61):149-152; doi 10.15574/SP.2014.61.149

Clinical and biochemical features of the liver disease among children with Epstein-Barr virus infection

Vygovskaya O. V., Shadrin V. O., Kramarev S. A. 
National medical university of A.A. Bogomolets, Kiev, Ukraine

Purpose: to study the frequency, the clinical and biochemical features of liver injury with Epstein-Barr virus infection (EBVI) among children.

Patients and methods: there were observed clinically and biochemically 303 children aged from 4 month to 18 years with EBVI, among them there were 243 patients with mononucleosis infectious and 60 patients with a chronic EBVI form.

Results: it was established that EBVI-etiology proceeded with the involvement in the pathological process of the hepatobiliary system, accompanied by the liver increase and its functional activity changes. The presence of hepatocellular lesions confirmed not only with the hepatic transaminases increased activity but also with the organ-specific enzymes changes – LDG and GAMMA-GT. 77.1% of children with an acute period noted the presence of cholestasis syndrome.

Conclusion: the highly informative for identifying the functional disorders of the hepatobiliary system and the spleen during an acute phase the next to the study of specific indicators is an ultrasound of the abdomen.

Key words: Epstein-Barr virus infection (EBVI), clinicoanamnestic analysis, hepatobiliary system.

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