• Characteristic of the clinical course of allergic diseases in children with vitamin D administrating in complex therapy.
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Characteristic of the clinical course of allergic diseases in children with vitamin D administrating in complex therapy.

SOVREMENNAYA PEDIATRIYA.2014.3(59):83-88; doi 10.15574/SP.2014.59.83

 

Characteristic of the clinical course of allergic diseases in children with vitamin D administrating in complex therapy.

 

Tyazhka O. V., Selska Z. V.

Bohomolets' National Medical University, Kyiv City, Ukraine

 

Purpose. Assess the clinical course of allergic diseases in children in the use of vitamin D in them.

 

Materials and methods. We observed 53 patients were children with allergic diseases — asthma, atopic dermatitis and allergic rhinitis. All children surveyed was determined 25(OH)D in serum. Among all the patients were children who received one course of vitamin D and patients who are vitamin D was administered in two treatments, then these patients was determined 25(OH)D in serum and the control group was children with allergic diseases which vitamin D not used. Definition hidroksykaltsyferolu performed using електрохемілюмінісцентного method. Assessing vitamin D was carried out according to the classification of MF Holick et al. (2011.)

 

Results. All 53 children (100% ), which was determined by the level of vitamin D in blood serum were determined deficiency of 25(OH)D, the average was 22.54 nmol/l. Treatment of vitamin D performed in 31 children, patients received 2000 IU of water-soluble vitamin D3 daily for 2 — oh months. After ingestion of vitamin D average rate of the vitamin in the serum was 36.54 nmol/l. Despite the insufficient level of 25(OH)D in serum, all children of vitamin D in the treatment of allergic diseases has been suspended in connection with the spring-summer period. The 19 children who were reported after the summer deficiency of vitamin D, cholecalciferol was appointed in high doses. Children receiving vitamin D dose of 4000 IU during remission and exacerbation of the disease and start to completion was 5000 IU dose, the treatment lasted for 2 months. After receiving vitamin D average 25 (OH)D levels was 44.08 nmol/l. Although children with allergies who used vitamin E, failed to reach normal values 25(OH)D in serum was noted improvement in their general condition and for the use of vitamin D in children allergic disease course was easier than the purpose of this vitamin in the treatment . In children (22 children) that vitamin D is not used , the improvement of general condition were observed, and the course of the underlying disease remained unchanged.

 

Conclusions. Thus, the use of vitamin D in the treatment of asthma, atopic dermatitis and allergic rhinitis in children makes it easier course of illness they have and improve their general condition. Presumably, vitamin D may one means of prevention and treatment of allergic diseases in children and is administered in the treatment for these patients.

 

Key wods. children, allergic disease, vitamin D , clinical treatment.

 

REFERENCES

1. Волосовець ОП, Кривопустов СП, Слюсар НА. 2009. Атопічний дерматит та пробіотики. Актуальні питання педіатрії, акушерства та гінекол. 1: 6—13.

2. Герасимов ОВ. 2013. Загальна якість життя дітей хворих на бронхіальну астму. Укр мед альм. 2(16): 103—106.

3. Іванців-Гріга ІС. 2009. Оптимізація вигодовування немовлят з групи підвищеного ризику реалізації харчової алергії. Актуальні питання педіатрії, акушерства та гінекол. 2: 28—30.

4. Квашніна ЛВ, Родіонов ВП, Оніськова ОВ. 2011. Застосування вітаміну D та його препаратів у сучасній педіатрії. Совр педиатрия. 6(40): 68—71.

5. Марушко ТВ. 2012. Роль елімінаційної терапії у лікуванні алергічного риніту у дітей. Совр педиатрия. 3(43): 73—78.

6. Holick MF, Binkley NC, Bischoff Ferrari HA. 2011. Evalution, treatment and prevention of vitamin D deficiency: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 96(7): 1911—19. http://dx.doi.org/10.1210/jc.2011-0385; PMid:21646368

7. Holick MF. 2008. Vitamin D deficiency: a worldwide problem with health consequences. Am J Clin Nutr. 87: 1080—1086.

8. Brehm JM, Celedon JC, Soto-Quiros ME et al. 2009. The level of vitamin D and markers of severity of asthma in children in Costa Rica. J Respir Critical Care Med. 179: 765—771. http://dx.doi.org/10.1164/rccm.200808-1361OC; PMid:19179486 PMCid:PMC2675563

9. Li F, Peng M, Jiang L et al. 2011. Vitamin D deficiency is associated with decreased lung function in Chinese adults with asthma. Breathing Epub. 81(6): 469—475. http://dx.doi.org/10.1159/000322008

10. Chinellato I, Piazza M, Sandri M et al. 2011. Vitamin D serum levels and markers of asthma control in Italian children. J Pediatr. 158(3): 437—441. http://dx.doi.org/10.1016/j.jpeds.2010.08.043; PMid:20870246