• Changes of erythrocyte indices in children with bronchial asthma, depending on severity of diseases and control level

Changes of erythrocyte indices in children with bronchial asthma, depending on severity of diseases and control level

PERINATOLOGY AND PEDIATRIC. UKRAINE. 2018.4(76):74-77; doi 10.15574/PP.2018.76.74

Dudnуk V. M., Zhmurchuk V. M.
Vinnytsya National Pirogov Memorial Medical University, Ukraine

Purpose — to define changes of erythrocyte indices in children with bronchial asthma, depending on severity of diseases and control level.

Patients and methods. 144 children with bronchial asthma were examined. In all children was evaluated number of hemoglobin, acount of erythrocytes and its morphology, erythrocyte sedimentation rate and level of serum iron. The analysis of morphometric parameters of peripheral blood red cells (MCV, MCH, MCHC, RBC, RDW, HCT) was performed with the Gobas Micros 18 hematologic analyzer. The amount of serum iron was determined by colorimetric method by reaction with ferrosine.

Results and conclusions. In the study of cytometric parameters of erythrocytes MCV, we found that all children with asthma had a significant (p<0.01) lower values of MCV by 15.32% compared to almost healthy children. Depending on MCV, microcytosis was found three times more frequently in patients with persistent severe asthma, than normocytosis in patients with persistent mild and moderate asthma. Microcytosis in patients with poorly controlled asthma was encountered 2 times more often in the group of patients with controlled asthma, which emphasizes the inability to achieve control of the disease in reducing the iron content of serum.

Key words: bronchial asthma, erythrocytes, children.

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Article received: Aug 04, 2018. Accepted for publication: Nov 29, 2018.