• Change in microcirculation levels under the influence of alternating magnetic field in the comprehensive treatment of children with suppurative wounds

Change in microcirculation levels under the influence of alternating magnetic field in the comprehensive treatment of children with suppurative wounds

PAEDIATRIC SURGERY.UKRAINE.2018.3(60):94-99; doi 10.15574/PS.2018.60.94

Spakhi O. V., Pacholchuk A. P.
Zaporizhzhia State Medical University, Ukraine

Objective: to study changes in the levels of microcirculation parameters (MP) in children with suppurative wounds when applying alternating magnetic field.

Materials and methods. In total 197 children with suppurative wounds during the period of 2012-2016 were examined. In the 1st group, the patients were administered the alternating magnetic field as a topical therapy of wound daily. The patients of the 2nd group underwent standard topical treatment for an acute purulent surgical infection. To study the microcirculation levels, the laser Doppler flowmetry (LDF) was used.

Results. According to LDF during the inflammatory stage of the wound process, an increase in the microcirculation index and the oscillating amplitude of microvasculature in the myogenic and neurogenic ranges was revealed. In 83 (81.4%) children, after the application of alternating magnetic field, the decrease in MP and the tone of microvasculature was determined as early as the third day of treatment, and in 73 (76.9%) children of the comparison group – the fifth day (p<0.05). Changes in microcirculation were accompanied by the onset of regenerative wound processes. The beginning of the reparative processes was accompanied by the MP increase, which gradually decreased to the reference area during the third stage, and the oscillating amplitude in the neurogenic and myogenic ranges did not differ significantly from the intact area. These changes caused by alternating magnetic field were determined in 89 (87.3%) cases on the fifth day, and in the comparison group in 73 (76.9%) cases on the seventh day (p<0.05).

Conclusions. Determining the microcirculation parameters of suppurative wounds may be used for the objective assessments of the wound process and treatment efficiency. Laser Doppler flowmetry is a sensitive method of the wound microcirculation examination and enable monitoring the progress of the wound process. Treatment of suppurative wounds by using alternating magnetic field improves microcirculation and creates conditions for the manifestation of a greater efficiency of drugs.

Key words: children, suppurative wounds, magnetic therapy, microcirculation, laser Doppler flowmetry.

References

1. Alekseeva NT. (2014). Morphological evaluation of regenerate during healing of purulent skin wounds under the influence of various methods of regional exposure. Zhurnal anatomy I gistopatologii. 3;2: 14-18.

2. Bezrukov SG, Grigorieva TS. (2012). Results of LDF monitoring in patients after surgical treatment with facial athere. Tavricheskii medico-biologicheskii vestnik. 15; 4(60):43-46.

3. Gluhov AA, Alekseeva NT. (2011). The use of programmable magnetotherapy in the treatment of purulent wounds of soft tissues. Mezhdunarodnii zhurnal prikladnikh i fundamentalnikh isledovanii. 9: 90-92.

4. Schapkin YuG, Kapralov SV, Strelnikov NYu. (2011). Laser Doppler flowmetry in the evaluation of the effectiveness of standard drug therapy for deep frostbites of extremities. Byulleten meditsinskih Internet-konferentsi. 1;2: 48-53.

5. Aziz Z, Flemming K. (2012). Electromagnetic therapy for treating pressure ulcers. Cochrane Database Syst Rev. 12: CD002930. https://doi.org/10.1002/14651858.CD002930.pub5; PMid:23235593

6. Choi HMC, Cheing AKK, Ng GYF, Cheing GLY. (2018). Effects of pulsed electromagnetic field (PEMF) on the tensile biomechanical properties of diabetic wounds at different phases of healing. PLoS One. 13(1):e0191074. https://doi.org/10.1371/journal.pone.0191074.

7. Choi MC, Cheung KK, Li X, Cheing GL. (2016). Pulsed electromagnetic field (PEMF) promotes collagen fibre deposition associated with increased myofibroblast population in the early healing phase of diabetic wound. Arch Dermatol Res. 308(1): 21–29. https://doi.org/10.1007/s00403-015-1604-9

8. Junka AF, Rakoczy R, Szymczyk P, Bartoszewicz M, Sedghizadeh PP, Fijałkowski K. (2018). Application of Rotating Magnetic Fields Increase the Activity of Antimicrobials Against Wound Biofilm Pathogens. Sci Rep. 8(1):167. https://doi.org/10.1038/s41598-017-18557-7.

9. Pesce M, Patruno A, Speranza L, Reale M. (2013). Extremely low frequency electromagnetic field and wound healing: implication of cytokines as biological mediators. Eur Cytokine Netw. 24(1):1-10. doi 10.1684/ecn.2013.0332.

10. Pilla AA. (2013). Nonthermal electromagnetic fields: from first messenger to therapeutic applications. Electromagn Biol Med. 32(2):123-36. https://doi.org/10.3109/15368378.2013.776335.

Article received: Mar 19, 2018. Accepted for publication: Sep 13, 2018.