• Cervical intraepithelial neoplasia (CIN). Modern approaches to the diagnosis, treatment and rehabilitation
To content

Cervical intraepithelial neoplasia (CIN). Modern approaches to the diagnosis, treatment and rehabilitation

HEALTH OF WOMAN. 2016.5(111):19–25; doi 10.15574/HW.2016.111.19

Cervical intraepithelial neoplasia (CIN). Modern approaches to the diagnosis, treatment and rehabilitation

Manzhura E. P.

Kyiv city clinical cancer center

A.A. Bogomolets National Medical University, Kiev

The aim of the study: to evaluate the clinical efficacy of the drug Ravitax in the form of vaginal plugs in the postoperative treatment of the cervix.

Materials and methods. To evaluate the clinical efficacy were studied 2 medicines in the group of patients after surgical treatment of the cervix, namely, candle Ravitax and candle Methyluracil. The study was open, in the examined group consisted of 50 women, 25 of whom were appointed candle Ravitax, and 25 – Methyluracil candles. All the patients were performed cervical conization by the united method – electrosurgical and in the postoperative period assigned to the candles once a day for the night # 14 from the 3rd postoperative day. Examination of patients was carried out for 30-35 days and 60-65 days after surgery. There were evaluated the degree of epithelialization, stricture of the cervical canal and bacterioscopy stroke, as well as the subjective feeling of the woman of comfort on a 10-point system.

Results. As can be seen from the results, patients who received the drug Ravitax in the form of vaginal plugs had a higher percentage of epithelialization, in contrast to patients treated with vaginal suppositories Methyluracil. So, under Ravitax 30-35 days of examination of epithelialization was higher by 13±2.3%, and 60-65 days – 12±3.4%. When examination noted that the wound surface was cleaned more effectively with the use of the drug Ravitax, the number of strictures after 2 months was 25% less and the comfort level was higher by 35.6%, which is very important for the quality of life of women. This action is generally due to the rational components of the drug Ravitax.

Conclusion. Thus, the drug Ravitax an exaggeration to say that he established himself in the past many years as an effective, reliable drug which improves reparative processes after operations on the cervix. It has no damaging effect on the epithelium, has no contraindications due to the lack of corrosive reagents. It was shown in reproductive, before and postmenopausal women.

Key words: pathology of the cervix, dysplasia, cancer, classification, Ravitax.


1. Patologiya sheyki i tela matki: rukovodstvo dlya vrachey. Pod red. Kohanevich EV. Nezhin, Gidromaks. 2009:350.

2. Bohman YaV, Lyutra UK. 1991. Rak sheyki matki. Kishinev, Shtiintsa. PMCid:PMC1792954

3. Fedorenko ZP, Gulak LO, Mihaylovich YuY, Goroh EL, Rizhov AYu, Sumkina OV, Kutsenko LB. Natsionalnyiy kantser-reestr v Ukraine.

4. Molochkov VA, Kiselev VI, Rudyih IV, Scherbo SN. 2004. Papillomavirusnaya infektsiya: klinika, diagnostika, lechenie: posobie dlya vrachey. M, MONIKI. PMid:15648168

5. Marchenko LA. 2001. Genitalnyiy gerpes. Novyie klinicheskie aspektyi. Problemyi reproduktsii 4:29–33.

6. Epidemiologiya raka sheyki matki, faktoryi riska, skrining (VI Novik, d-r. med. nauk,NII onkologii im. prof. N.N. Petrova Minzdrava RF, Sankt-Peetrburg, HPV info.ru).

7. Urmancheeva AF, Merabishvili VM, Selkov SA i dr. 2001. Epidemiologiya i diagnostika raka sheyki matki. Akush. i gin. XLX;1:80–86.

8. Batkaev EA, Kitsak VYa, Korsunskaya IM, Lipova EV. 2001. Virusnyie zabolevaniya kozhi i slizistyih: uchebnoe posobie. M.

9. Podzolkova NM, Sozaeva LG, Osadchev VB. 2007. Papillomavirusnaya i gerpeticheskaya infektsii v akusherstve i ginekologii. Uchebno-metodicheskoe posobie. M:46.

Prilepskaya VN. 1997. Zabolevaniya sheyki matki. Klinicheskie lektsii. M.

10. Kiselev VI, Kiselev OI. 2003. Virusyi papillomyi cheloveka v razvitii raka sheyki matki. SPb-M.

11. Cancer: Principes and Practice of Oncology. Ed. by VT DeVita, S Hellvan, SA Rosenberg 5th Edition, 1997.

12. Kapp K, Stuecklschweiger G, Kapp D. 1997. Carcinoma of the cervix: analysis of complications after primary external beam radiation and Ir-192 HDR brachytherapy. Radiother.Oncol. 42:143–153. http://dx.doi.org/10.1016/S0167-8140(96)01881-6

13. Richart RM, Barron BA. 1969. A follow-up study of patients with cervical dysplasia. Amer. J. Obstet. Gynecol. 105:386–393. http://dx.doi.org/10.1016/0002-9378(69)90268-3

14. Koutsky LA, Kiviar NB. 1999. Genital human papillomavirus. In:Sexual Transmited Diseases. Ed. KK Holmes et al. 3rd ed.-Mc.Grow-Hill. NewYork:347–160.