• Association of genetic polymorphism and clinical symptoms during the infancy stroke
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Association of genetic polymorphism and clinical symptoms during the infancy stroke

SOVREMENNAYA PEDIATRIYA.2015.3(67):92-99; doi10.15574/SP.2015.67.92

 

Association of genetic polymorphism and clinical symptoms during the infancy stroke

 

Smulskaya N. E.

Kyiv City Children's Clinical Hospital №1, Ukraine

 

Objective. To study the effect of genetic polymorphism of MTHFR (C677T), MTHFR (A1298C), MTRR (A66G)FV (G1691A), FII (G20210A), ACE (I/D) genes on the prevalence and nature of clinical symptoms in children with stroke in the acute period and the period of residual effects with the aim of prediction of future course of the disease.

 

Patients and methods. The analysis of the association of genetic polymorphism of MTHFR (C677T), MTHFR (A1298C), MTRR (A66G), FV (G1691A), FII (G20210A), ACE (I / D) genes with the presence of clinical symptoms of acute infancy stroke and the period of residual effects in patients in the age from the birth till 15 years after one year is conducted.

 

Results. The development of severe motor disorders in the acute period in the general group of patients with stroke was associated with genotype 1298AC gene MTHFR, convulsive syndrome was associated with genotypes 677TT MTHFR gene and DD gene ACE, 677CC and II genotype reduced the risk of convulsive syndrome in children with ischemic stroke; at presence of hemorrhagic stroke convulsive syndrome of acute period was associated with genotype 1298AC MTHFR gene; One year after acute stroke development in children of the general group the presence of heavy motor disorders were associated with genotype 1298AC MTHFR gene, delaying of mental and speech development with genotypes 677TT MTHFR gene and 1298AC MTHFR gene.

 

Conclusions. Definition of genetic features in patients indicates about the possibility of the use of genetic test for prediction of the course of the disease.

 

Key words: stroke, children, genes, seizures, movement disorders, developmental delay.

 

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