• Approaches to the development of clinical criteria for cases suspected of primary immunodeficiency (literature review)

Approaches to the development of clinical criteria for cases suspected of primary immunodeficiency (literature review)

SOVREMENNAYA PEDIATRIYA.2018.8(96):92-98; doi 10.15574/SP.2018.96.92

Beglaryan S. A., Chernyshova L. I.
Shupyk National Medical Academy of Postgraduate Education, Kyiv, Ukraine

Topicality. For 2018, there are more than 350 nosologies of primary immunodeficiencies. Most cases of congenital immunodeficiencies remain undiagnosed due to the absence of pathognomonic symptoms with them and the low level of doctors' awareness of this pathology. Primary (congenital) immunodeficiencies are not fatal nowadays, as they can be treated. In case of the early diagnosing, children get a chance for a full life and, often, a complete recovery. So, development of criteria for identifying cases suspected of primary immunodeficiency is important.

Objective: Study of existing approaches to the development of clinical criteria for the detection of primary immunodeficiencies.

Material and methods. Collection and analysis of existing literature on clinical criteria related to manifestations of primary immunodeficiencies.

Results. We analyzed 13 works about development of criteria for primary immunodeficiencies diagnosis. Throughout the world, including Ukraine, a number of criteria have been developed, which may be clinical markers of suspected congenital immunodeficiency. There were different approaches for the development of clinical criteria for primary immunodeficiencies such as calculating the symptoms frequency, the χ2 fourfold table, regression analysis and making of an immunodeficiency4related score for assessing the hospitalized patients' diagnoses through the computer screening. One work shows separately developed criteria for children and adults.

Conclusions. The analysis of literature showed different methods for identifying patients with primary immunodeficiencies. Existing approaches can be a precondition for the further clinical criteria development for the early detection of primary immunodeficiencies.

Key words: paediatric immunology, primary immunodeficiencies, clinical criteria.

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Article received: Jul 21, 2018. Accepted for publication: Dec 01, 2018.