• Antiemetic therapy of early toxicity in pregnant women with congenital heart disease 
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Antiemetic therapy of early toxicity in pregnant women with congenital heart disease 

PERINATOLOGIYA I PEDIATRIYA. 2016.3(67):35-37; doi 10.15574/PP.2016.67.35 

Antiemetic therapy of early toxicity in pregnant women with congenital heart disease 

Davydova I. V., Limanskaya A. Yu., Butenko L. P., Ogorodnik A. A.

SI «Institute of Pediatrics, Obstetrics and Gynecology NAMS of Ukraine», Kiev 

Objective — to study the effectiveness of the Yunorm (Yuria-Farm) in the treatment of early severe toxicity in pregnant women with cardiovascular disease and anemia.

Patients and methods. We examined 28 women with congenital heart disease and anemia who had received Yunorm (Yuria-Farm) intravenously by 2 ml (4 mg of ondansetron) per day (in severe cases twice a day) for the relief of emesis and nausea as a manifestation of moderate and severe early toxicity in pregnant women.

Results. The high efficiency and safety of Yunorm (ondansetron) preparation, which was administrated intravenously for the treatment of nausea and vomiting during pregnancy is found. The safety of the use during gestation period was confirmed by the absence of significant side effects in women, significant changes in the fetus state and newborn.

Conclusions. According to its safety profile ondansetron is qualified as B according to the FDA classification and can be recommended as an effective and safe anti-emetic preparation for use in obstetric practice.

Key words: toxemia of pregnancy, cardiovascular disease, anemia, antiemetic therapy.


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