• Аnalysis of education indicators of fibrosis in pyelonephritis on the background of vesicoureteral reflux in children of early age 
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Аnalysis of education indicators of fibrosis in pyelonephritis on the background of vesicoureteral reflux in children of early age 

SOVREMENNAYA PEDIATRIYA.2015.6(70):93-96; doi 10.15574/SP.2015.70.93 
 

Аnalysis of education indicators of fibrosis in pyelonephritis on the background of vesicoureteral reflux in children of early age 
 

Tokarchuk N. I., Odarchuk I. V., Zayichko N. V.

Vinnitsya national medical university 
 

The objective. To determine the levels of TGF-B1 and galectin 3 pyelonephritis against the background of vesicle-urethral reflux. 
 

Patients and methods. The observation of 55 infants of patients with pyelonephritis who were on the treatment course in Khmelnytsky regional children's hospital. The first subgroup consisted of 28 children with pyelonephritis without evidence of vesiculo-urethrally reflux (primary pyelonephritis) and the second subgroup consisted of 27 young children of patients with pyelonephritis on the background of the vesiculo-urethrally reflux (secondary pyelonephritis). The control group consisted of 24 healthy children. The content of TGFB1 and galectin_3 was determined by enzyme immunoassay (ELISA). 
 

Results. Plasma concentration of transforming growth factor B1 and galectin-3 were significantly higher in children with pyelonephritis on the background of vesicoureteral reflux than in patients with primary pyelonephritis, indicating a possible fibrosis formation in the kidneys. It is established that with increasing length of pyelonephritis increased level profibrotic indicators. When SPN most children (81.4%) found the reduction of the thickness of the renal parenchyma according to the indicators of renal cortical index, which indicates the possibility of reducing the functional capacity of the kidneys. High sensitivity (TGF-B1 — 85%, the galectin-3 — 92%) and specificity (TGF-B1 — 67%, galectin-3 — 82%) for both indicators in pyelonephritis on the background of vesicoureteral refluxa indicates the need for a definition of these indicators in children of early age, as early markers of fibrosis formation. 
 

Conclusion. Perspective is further investigations of the pathogenetic aspects of the formation of irreversible changes in the kidney in pyelonephritis on the background of vesicoureteral reflux in children of early age. 
 

Key words: pyelonephritis, infants, transforming growth factor, galectin 3. 
 

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