• An unified clinical protocols of the medical care for children with an irritable bowel syndrome  The value of the synbiotics in the therapy and prevention of an antibiotic-associated diarrhea among childre
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An unified clinical protocols of the medical care for children with an irritable bowel syndrome  The value of the synbiotics in the therapy and prevention of an antibiotic-associated diarrhea among childre

SOVREMENNAYA PEDIATRIYA.2014.6(62):89-94; doi 10.15574/SP.2014.62.89

An unified clinical protocols of the medical care for children with an irritable bowel syndrome 
The value of the synbiotics in the therapy and prevention of an antibiotic-associated diarrhea among children

Lezhenko G. A., Pashkova E. E. 
Zaporizhia State Medical University, Ukraine

Purpose: studying of the effectiveness of synbiotic «Kolifagina PRO» in the prevention of an antibiotic-associated diarrhea (AAD) among children with the bacterial respiratory pathology.

Patients and methods: there were examined 30 children aged from 3 to 7 years. All children received the cephalosporins III generation intravenously. The first group consisted of 15 children who got an antibiotic therapy from the first day with the probiotic (Kolifagina PRO),the second group were the rest 15 patients. According to the patients testimony there was conducted the bacteriological examination of the intestinal microflora.

Results: in the group of children treated from the first day with an antibiotic therapy «Kolifagina PRO»,there were no cases of diarrhea. In the second group from the third day of an antibiotic therapy in 5 (33.3%) of the patients had loose stools, 2 patients (13.3%) developed an antibiotic-associated colitis. All children with the AAD sign had an irregularity intestinal biocenosis. Applying the «Kolifagina PRO», children with AAD had the reverse development of the gastrointestinal disorders occurred on 4-5day, and the complete disappearance of the dyspeptic manifestations – on 7 day.

Conclusions: the use of «Kolifagina PRO» from the first day of an antibiotic therapy promotes an effective AAD prevention. The synbiotic appointment on the background of the onset of AAD symptoms reduces the severity and duration of the diarrhea. The presence of the prebiotic fibers in the «Kolifagina PRO» is a prerequisite for further colonization adequate and effective immunomodulation.

Key words: symbiotic, an antibiotic-associated diarrhea,children, Kolifagina PRO.

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