• An unified clinical protocols of the medical care for children with an irritable bowel syndrome  The value of the synbiotics in the therapy and prevention of an antibiotic-associated diarrhea among childre
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An unified clinical protocols of the medical care for children with an irritable bowel syndrome  The value of the synbiotics in the therapy and prevention of an antibiotic-associated diarrhea among childre

SOVREMENNAYA PEDIATRIYA.2014.6(62):89-94; doi 10.15574/SP.2014.62.89

An unified clinical protocols of the medical care for children with an irritable bowel syndrome 
The value of the synbiotics in the therapy and prevention of an antibiotic-associated diarrhea among children

Lezhenko G. A., Pashkova E. E. 
Zaporizhia State Medical University, Ukraine

Purpose: studying of the effectiveness of synbiotic «Kolifagina PRO» in the prevention of an antibiotic-associated diarrhea (AAD) among children with the bacterial respiratory pathology.

Patients and methods: there were examined 30 children aged from 3 to 7 years. All children received the cephalosporins III generation intravenously. The first group consisted of 15 children who got an antibiotic therapy from the first day with the probiotic (Kolifagina PRO),the second group were the rest 15 patients. According to the patients testimony there was conducted the bacteriological examination of the intestinal microflora.

Results: in the group of children treated from the first day with an antibiotic therapy «Kolifagina PRO»,there were no cases of diarrhea. In the second group from the third day of an antibiotic therapy in 5 (33.3%) of the patients had loose stools, 2 patients (13.3%) developed an antibiotic-associated colitis. All children with the AAD sign had an irregularity intestinal biocenosis. Applying the «Kolifagina PRO», children with AAD had the reverse development of the gastrointestinal disorders occurred on 4-5day, and the complete disappearance of the dyspeptic manifestations – on 7 day.

Conclusions: the use of «Kolifagina PRO» from the first day of an antibiotic therapy promotes an effective AAD prevention. The synbiotic appointment on the background of the onset of AAD symptoms reduces the severity and duration of the diarrhea. The presence of the prebiotic fibers in the «Kolifagina PRO» is a prerequisite for further colonization adequate and effective immunomodulation.

Key words: symbiotic, an antibiotic-associated diarrhea,children, Kolifagina PRO.

1. Белоусова ОЮ. 2011. Дисбактериоз кишечника как фактор риска развития хронических заболеваний кишечника у детей. Здоровье ребенка. 1: 73—75.

2. Захарова ИН, Дмитриева ЮА. 2011. Перспективы использования продуктов функционального питания у детей раннего возраста. Вопр совр педиатрии. 10;2: 150—154.

3. Осипенко МФ, Бикбулатова ЕА, Холин СИ. 2008. Пробиотики в лечении диарейного синдрома. Фарматека. 13: 36—41.

4. Сурков АН. 2011. Современные технологии в лечении и профилактике антибиотик-ассоциированной диареи у детей. Вопр совр педиатрии. 10;5: 146—151.

5. Успенский ЮП, Фоминых ЮА. 2013. Антибиотик-ассоциированная диарея — новая проблема цивилизации. Архивъ внутренней медицины. 2: 46—52.

6. Шевяков МА. 2004. Антибиотик-ассоциированная диарея и кандидоз кишечника: возможности лечения и профилактики. Антибиотики и химиотерапия. 49(10): 26—29.

7. Янковский ДС, Дымент ГС. 2006. Бифидобактерии и лактобациллы как оптимальная основа современных пробиотиков. Совр педиатрия. 3: 184—194.

8. Conway PL, Gorbach SL, Goldin BR. 1987. Survival of lactic acid bacteria in the human stomach and adhesion to intestinal cells. J of Dairy Science. 70(1): 1-12.

9. Armuzzi A, Cremonini F, Ojetti V et al. 2001. Effect of Lactobacillus GG supplementation on antibiotic-associated gastrointestinal side effects during. Digestion. 63(1): 1—7. http://dx.doi.org/10.1159/000051865; PMid:11173893

10. Huang JS, Bousvaros A, Lee JW et al. 2002. Efficacy of probiotic use in acute diarrhea in children: a metaanalysis. Dig Dis Sci. 11: 2625—2634.

11. Sazawal S, Hiremath G, Dhingra U et al. 2006. Efficacy of probiotics in prevention of acute diarrhoea: a meta-analysis of masked, randomized, placebo-controlled trials. Lancet Infect Dis. 6: 374—382.

12. Wisham J, Norrby SR, Myhre CB et al. 2001. Frequency of antibiotic-associated diarrhea in 2462 antibiotic-treated hospitalized patients: a prospective study. Antimicrob Chemother. 47: 43—50.

13. Gorkiewicz G. 2009. Nosocomial and antibiotic_associated diarrhoea caused by organisms other than Clostridium difficile. Int J Antimicrob Agents. 33;Suppl 1: 37—44.

14. Gupta V, Garg R. 2009. Probiotics. Indian Journal of Medical Microbioloy. 27(3): 202—209. http://dx.doi.org/10.4103/0255-0857.53201; PMid:19584499

15. Gupte N, Gupte S, Anderson RA. 2013. Antibiotic-associated Diarrhea. Recent Advances in Pediatrics. Pediatric Gastroenterology, Hepatology and Nutrition. 23: 82—94.

16. Johnston BC, Supina AL, Vohra S. 2006. Probiotics for pediatric antibiotic-associated diarrhea: a meta-analysis of randomized placebo-controlled trials. CMAJ. 175(4): 377—383. http://dx.doi.org/10.1503/cmaj.051603

17. Guandalini S, Pensabene L, Abu Zikri M et al. 2000. Lactobacillus GG Administered in oral rehydration solution to children with acute diarrhea: A multi-center European trial. J of Pediatric Gastroenterology & Nutrition. 30: 54—60.

18. McFarland LV. 2006. Meta-analysis of probiotics for the prevention of antibiotic associated diarrhea and the treatment of Clostridium difficile disease. Am J Gastroenterol. 101(4): 812—822.

19. Cremonini F, Di Caro S, Nista EC et al. 2002. Meta-analysis: the effect of probiotic administration on antibiotic-associated diarrhoea. Aliment Pharmacol Ther. 16(8): 1461—1467. http://dx.doi.org/10.1046/j.1365-2036.2002.01318.x; PMid:12182746

20. Reid G, Jass J, Sebulski MT et al. 2003. Potential uses of probiotics in clinical practice. Clin Microbiol Rev. 16(4): 658—672. http://dx.doi.org/10.1128/CMR.16.4.658-672.2003; PMid:14557292 PMCid:PMC207122

21. Jeon SG, Kayama H, Ueda Y et al. 2012. Probiotic Bifidobacterium breve induces IL-10-producing Tr1 cells in the colon. PLoS pathogens. 8(5): e1002714.

22. Johnston BC, Supina AL, Ospina M et al. 2007. Probiotics for the prevention of pediatric antibiotic_associated diarrhea. Cochrane Database Syst Rev. 2: CD004827.

23. D'Souza AL, Rajkumar C, Cooke J et al. 2002. Probiotics in prevention of antibiotic associated diarrhoea: meta-analysis. BMJ. 324(7350): 1361. http://dx.doi.org/10.1136/bmj.324.7350.1361

24. Szajewska H, Ruszczynski M, Radzikowski A. 2006. Probiotics in the prevention of antibiotic-associated diarrhea in children: a metaanalysis of randomized controlled trials. J Pediatr. 149(3): 367—372.

25. Theriot C, Young VB. 2014. Antibiotic-Associated Diarrhea. Encyclopedia of Metagenomics: 1—7.