- Evaluation of risk of miscarriage depending on genetic characteristics of a woman
Evaluation of risk of miscarriage depending on genetic characteristics of a woman
PERINATOLOGY AND PEDIATRIC. UKRAINE. 2018.1(73):74-79; doi 10.15574/PP.2018.73.74
Tkachenko V. B., Razdaibieidina A. S., Vorobiova I. I.
SI «Institute of Pediatrics, Obstetrics and Gynaecology of NAMS of Ukraine», Kyiv, Ukraine
Taras Shevchenko National University of Kyiv, Ukraine
Objective — to study the relationship between the single nucleotide polymorphisms of Toll_like receptors, cytokines, progesterone gene and the risk of spontaneous abortion.
Material and methods. Single nucleotide polymorphisms of such genes (TLR2 G753A, TLR4 C399T, TLR9G2848A, TGF-β1 C509T, PGR PROGINS, IL-6 G174C, IL-8 C781T, IL-10C592A, TNFα G308A) were studied in 106 women whose pregnancy ended in miscarriage and in 74 women who delivered in term without any pregnancy complication. All participants were Ukrainian women.
Results. According to the data obtained, the genotypes of genes that dramatically increase the risk of spontaneous abortion in the order of decreasing odds ratio are as follows: TLR9 AA, ІL-10 АА, TLR2 GA, PROGINS Т2/Т2, TLR4 CT, TLR9 GA, IL-10 СА, IL-6 GC, TGF-β CC. The most significant mutant alleles of the studied genes, which significantly increase the risk of spontaneous abortion, in order of decreasing odds ratios are as follows: TLR9A, TLR2A, IL-10A, TLR4T, TNFα A.
Conclusions. The detected genotypes and allelic polymorphisms play a critical role in miscarriage.
Key words: miscarriage, spontaneous abortion, cytokines, Toll-like receptors, progesterone, polymorphism.
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