SOVREMENNAYA PEDIATRIYA. 2015.2(66):32-36; doi 10.15574/SP.2015.66.32

Бета-гемолітичний стрептокок групи A: актуальна проблема сьогодення і перспективи її вирішення

Овчаренко Л. С., Вертегел А. О., Андрієнко Т. Г., Жихарева Н. В., Самохін І. В., Кряжев О. В.

ДЗ «Запорізька медична академія післядипломної освіти МОЗ України»

У статті наведено огляд літератури за результатами сучасних досліджень щодо поширеності у дітей захворювань, спричинених β-гемолітичним стрептококом групи А (Streptococcus pyogenes), їх клінічних проявів, інформативних методів діагностики, ефективних способів терапії та профілактики; перспективи створення імуногенних і безпечних вакцин проти даного мікроорганізму.

Ключові слова: діти, бета-гемолітичний стрептокок групи А, терапія, антибіотики, профілактика.

REFERENCES 
1. Ray D, Banerjee S, Bhattacharya S et al. 2010. A hospital_based study to evaluate the incidence pattern of group A streptococcal throat infections from different age group patients. J Indian Med Assoc. 108(2): 81—83.

2. Sanderson-Smith M, De Oliveira DM, Guglielmini J et al. 2014. A systematic and functional classification of Streptococcus pyogenes that serves as a new tool for molecular typing and vaccine development. J Infect Dis. 210(8): 1325—1338.

3. Guilherme L, Moraes Ferreira F, Kuhler KF et al. 2013. A Vaccine against Streptococcus pyogenes. Am J of Cardiovascular Drugs. 13(1): 1—4. http://dx.doi.org/10.1007/s40256-013-0005-8; PMid:23355360

4. Gorphe P, de Barros A, Choussy O et al. 2012. Acute mastoiditis in children: 10 years experience in a French tertiary university referral center. Eur Arch Otorhinolaryngol. 269(2): 455—460.

5. Angoulvant F, Bellanger H, Magnier S et al. 2011. Acute purulent pericarditis in childhood: don't forget β-haemolytic group-A Streptococcus. Intensive Care Med. 37(10): 1709—1710. http://dx.doi.org/10.1007/s00134-011-2259-4; PMid:21618000

6. Allen UD, Moore DL. 2010. Invasive group A streptococcal disease: Management and chemoprophylaxis. Can J Infect Dis Med Microbiol. 21(3): 115—118.

7. Brook I. 2011. Microbiology of sinusitis. Proc Am Thorac Soc. 8(1): 90—100. http://dx.doi.org/10.1513/pats.201006-038RN; PMid:21364226

8. Brook I. 2007. Overcoming penicillin failures in the treatment of Group A streptococcal pharyngo_tonsillitis. Int J of Pediatric Otorhinolaryngology. 71: 1501—1508.

9. Thenmozhi R, Balaji K, Kumar R et al. 2011. Characterization of biofilms in different clinical M serotypes of Streptococcus pyogenes. J Basic Microbiol. 51(2): 196—204. http://dx.doi.org/10.1002/jobm.201000006; PMid:21298675

10. Rodriguez-Nunez A, Dosil-Gallardo S, Jordan I, hoc Streptococcal Toxic Shock Syndrome collaborative group of Spanish Society of Pediatric Intensive Care. 2011. Clinical characteristics of children with group A streptococcal toxic shock syndrome admitted to pediatric intensive care units. Eur J Pediatr. 170(5): 639—644.

11. Murphy TK, Storch EA, Lewin AB et al. 2012. Clinical factors associated with pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections. J Pediatr. 160(2): 314—319.

12. Park SY, Gerber MA, Tanz RR et al. 2006. Clinicians' Management of Children and Adolescents With Acute Pharyngitis. Pediatrics. 117: 1871—1878.

13. Cohen R. 2007. Pharyngitis in children. Rev Prat. 57(16): 1777—1780, 1782—1783.

14. Committee on Infectious Diseases. Red Book. 28th ed. Elk Grove Village, IL, American Academy of Pediatrics. 2009.

15. Montes M, Ardanuy C, Tamayo E et al. 2011. Epidemiological and molecular analysis of Streptococcus pyogenes isolates causing invasive disease in Spain (1998—2009): comparison with non-invasive isolates. Eur J Clin Microbiol Infect Dis. 30(10): 1295—1302. http://dx.doi.org/10.1007/s10096-011-1226-x; PMid:21491178

16. Lepoutre A, Doloy A, Bidet P et al. 2011. Epidemiology of Invasive Streptococcus pyogenes Infections in France in 2007. J Clin Microbiol. 49(12): 4094—4100. http://dx.doi.org/10.1128/JCM.00070-11; PMid:21976764 PMCid:PMC3232948

17. Hayashi A, Takano T, Suzuki A, Narumiya S. 2011. Group A streptococcal brain abscess: a case report and a review of the literature since 1988. Scand J Infect Dis. 43(6—7): 553—555.

18. Mir F, Tikmani SS, Shakoor S et al. 2011. Incidence and etiology of omphalitis in Pakistan: a community-based cohort study. J Infect Dev Ctries. 13(12): 828—833.

19. Hertzen E, Johansson L, Kansal R et al. 2012. Intracellular Streptococcus pyogenes in Human Macrophages Display an Altered Gene Expression Profile. PLoS ONE. 7(4): e35218.

20. Tasher D, Stein M, Simoes EA et al. 2011. Invasive bacterial infections in relation to influenza outbreaks, 2006—2010. Clin Infect Dis. 53(12): 1199—1207. http://dx.doi.org/10.1093/cid/cir726; PMid:22021918

21. Imohl M, van der Linden M, Reinert RR, Ritter K. 2011. Invasive group A streptococcal disease and association with varicella in Germany, 1996—2009. FEMS Immunol Med Microbiol. 62(1): 101—109. http://dx.doi.org/10.1111/j.1574-695X.2011.00788.x; PMid:21314732

22. Olafsdottir LB, Erlendsdottir H, Melo-Cristino J et al. 2014. Invasive infections due to Streptococcus pyogenes: seasonal variation of severity and clinical characteristics, Iceland, 1975 to 2012. Euro Surveill. 19(17): 34—41. http://dx.doi.org/10.2807/1560-7917.es2014.19.17.20784

23. Jackson SJ, Steer AC, Campbell H. 2011. Systematic Review: Estimation of global burden of non-suppurative sequelae of upper respiratory tract infection: rheumatic fever and post-streptococcal glomerulonephritis. Trop Med Int Health. 16(1): 2—11. http://dx.doi.org/10.1111/j.1365-3156.2010.02670.x; PMid:21371205

24. Kronman MP, Zhou C, Mangione-Smith R. 2014. Bacterial prevalence and antimicrobial prescribing trends for acute respiratory tract infections. Pediatrics. 134(4): e956—965.

25. Langlois DM, Andreae M. 2011. Group A streptococcal infections. Pediatr. Rev. 32(10): 423—429.

26. Hraoui M, Boutiba-Ben Boubaker I, Doloy A et al. 2011. Molecular mechanisms of tetracycline and macrolide resistance and emm characterization of Streptococcus pyogenes isolates in Tunisia. Microb Drug Resist. 17(3): 377—382. http://dx.doi.org/10.1089/mdr.2010.0160; PMid:21612508

27. Torretta S, Marchisio P, Drago L et al. 2012. Nasopharyngeal biofilm-producing otopathogens in children with nonsevere recurrent acute otitis media. Otolaryngol Head Neck Surg. 146(6): 991—996.

28. Martic J, Mijac V, Jankovic B et al. 2010. Neonatal cellulitis and sepsis caused by group A streptococcus. Pediatr Dermatol. 27(5): 528—530. http://dx.doi.org/10.1111/j.1525-1470.2010.01262.x; PMid:20807361

29. Dale JB, Penfound TA, Chiang EY, Walton WJ. 2011. New 30-valent M protein_based vaccine evokes cross-opsonic antibodies against non-vaccine serotypes of group A streptococci. Vaccine. 29(46): 8175—8178. http://dx.doi.org/10.1016/j.vaccine.2011.09.005; PMid:21920403 PMCid:PMC3195966

30. O'Sullivan C, Baker MG. 2012. Serious skin infections in children: a review of admissions to Gisborne Hospital (2006—2007). N Z Med J. 125(1351): 55—69.

31. Bisno AL, Gerber MA, Gwaltney Jr JM et al. 2002. Practice guidelines for the diagnosis and management of group A streptococcal pharyngitis. Infectious Diseases Society of America. Clin Infect Dis. 35(2): 113—125.

32. Gerber MA, Baltimore RS, Eaton CB et al. 2009. Prevention of rheumatic fever and diagnosis and treatment of acute streptococcal pharyngitis: a scientific statement from the American Heart Association Rheumatic Fever, Endocarditis, and Kawasaki Disease Committee of the Council on Cardiovascular Disease in the Young, the Interdisciplinary Council on Functional Genomics and Translational Biology, and the Interdisciplinary Council on Quality of Care and Outcomes Research: endorsed by the American Academy of Pediatrics. Circulation. 119(11): 1541—1551. http://dx.doi.org/10.1161/circulationaha.109.191959

33. Ellis NM, Kurahara DK, Vohra H et al. 2010. Priming the immune system for heart disease: a perspective on group A streptococci. J Infect Dis. 202(7): 1059—1067.

34. Lean WL, Arnup S, Danchin M, Steer AC. 2014. Rapid Diagnostic Tests for Group A Streptococcal Pharyngitis: A Meta-analysis. Pediatrics. 134(771): 771—781. http://dx.doi.org/10.1542/peds.2014-1094

35. McNeil SA, Halperin SA, Langley JM et al. 2005. Safety and immunogenicity of 26-valent group A streptococcus vaccine in healthy adult volunteers. Clin Infect Dis. 41: 1114—1122.

36. Lithgow A, Duke T, Steer A, Smeesters PR. 2014. Severe group A streptococcal infections in a paediatric intensive care unit. J Paediatr Child Health. 50(9): 687—692. http://dx.doi.org/10.1111/jpc.12601; PMid:24909187

37. Shaikh N, Swaminathan N, Hooper EG. 2012. Accuracy and precision of the signs and symptoms of streptococcal pharyngitis in children: a systematic review. J Pediatr. 160(3): 487-493.e3.

38. Steer AC, Dale JB, Carapetis JR. 2013. Progress Toward a Global Group A Streptococcal Vaccine. The Pediatric Infectious Disease Journal. 32(2): 180—182. http://dx.doi.org/10.1097/INF.0b013e318281da11; PMid:23328823

39. Stein R. Manson D. 2012. Magnetic resonance imaging findings of empyema necessitatis in a child with a group A streptococcus infection. J Thorac Imaging. 27(1): 13—14. http://dx.doi.org/10.1097/RTI.0b013e31820a94a0; PMid:21364472

40. Millender TW, Reller LB, Meekins LC, Afshari NA. 2012. Streptococcal pharyngitis leading to corneal ulceration. Ocul Immunol Inflamm. 20(2): 143—144. http://dx.doi.org/10.3109/09273948.2011.649152; PMid:22360434

41. Juhn YJ, Frey D, Li X, Jacobson R. 2012. Streptococcus pyogenes upper respiratory infection and atopic conditions other than asthma: a retrospective cohort study. Prim Care Respir J. 21(2): 153—158. http://dx.doi.org/10.4104/pcrj.2011.00110; PMid:22270478

42. Rimoin AW, Walker CL, Hamza HS et al. 2010. The utility of rapid antigen detection testing for the diagnosis of streptococcal pharyngitis in low-resource settings. Int J Infect Dis. 14(12): 1048—1053. http://dx.doi.org/10.1016/j.ijid.2010.02.2269; PMid:21036645

43. Liadaki K, Petinaki E, Skoulakis C et al. 2011. Toll-like receptor 4 gene (TLR4), but not TLR2, polymorphisms modify the risk of tonsillar disease due to Streptococcus pyogenes and Haemophilus influenzae. Clin Vaccine Immunol. 18(2): 217—222. http://dx.doi.org/10.1128/CVI.00460-10; PMid:21159925 PMCid:PMC3067360

44. United Kingdom Department of Health Chief Medical Officer. Influenza, meningococcal infection and other bacterial co-infection including pneumococcal and invasive group A streptococcal infection (iGAS). London, DH. 10 January 2011.

45. Van De Voorde III RG. 2015. Acute Poststreptococcal Glomerulonephritis: The Most Common Acute Glomerulonephritis. Pediatrics in Review. 36(3): 3—13. http://dx.doi.org/10.1542/pir.36-1-3; PMid:25554106

46. Wessels MR. 2011. Streptococcal Pharyngitis. N Engl J Med. 364: 648—655.