• Репродуктивное здоровье женщин, больных рассеянным склерозом: современное состояние проблемы (Обзор литературы)

Репродуктивное здоровье женщин, больных рассеянным склерозом: современное состояние проблемы (Обзор литературы)

HEALTH OF WOMAN.2017.1(117):158–161

Негрич О. И., Пирогова В. И.
Львовский национальный медицинский университет имени Данила Галицкого

В статье приведены данные о современном состоянии изучения репродуктивного здоровья женщин, больных рассеянным склерозом.

Ключевые слова: репродуктивное здоровье, рассеянный склероз, сексуальная дисфункция, беременность.

Литература:

1. Белова А.Н. Рассеянный склероз и беременность / А.Н. Белова, Т.С. Качалина, В.Н. Крупин // Неврологический журнал. – 2010.– № 6.– С. 4–10.

2. Негрич Т.І. Особливості перебігу розсіяного склерозу в жінок у період вагітності та вплив патогенетичного лікування на стан плода та новонародженого / Т.І. Негрич, М.С. Шоробура, Н.О. Негрич // Міжнародний неврологічний журнал. – 2013.– № 1.– С. 11–16.

3. Оринчак Л.Б. Вплив віку менархе та сімейного стану у хворих на розсіяний склероз жінок на клінічні характеристики цього захворювання / Л.Б. Оринчак // Міжнародний неврологічний журнал. – 2015.–  .– С. 151–156.

4. Радзіховська Н.С. Сексуальна дисфункція у хворих на розсіяний склероз різної тяжкості і тривалості / Н.С. Радзіховська, Л.І. Соколова // Український неврологічний журнал. – 2014.– № 1.– С. 75–80.

5. Статистичні дані [Електронний ресурс] // Українська база медико-статистичної інформації. – 2016. – Режим доступу до ресурсу: http: //medstat.gov.ua/ukr/statreports.html

6. Airas L. Breast-feeding, postpartum and prepregnancy disease activity in multiple sclerosis / L. Airas, A. Jalkanen, A. Alanen // Neurology.– 2011.– V. 75(5).– P. 474–476. https://doi.org/10.1212/WNL.0b013e3181eb5860; PMid:20679640

7. Airas L. Hormonal and gender-related immune changes in multiple sclerosis / L. Airas // Acta Neurol Scandinavica.– 2015.– V. 132.– P. 62–70. https://doi.org/10.1111/ane.12433; PMid:26046561

8. Airas Pregnancy and multiple sclerosis / Airas, L., Kaaja [et al.] // Obstetric Med.– 2012.– V. 5.– P. 94–97. https://doi.org/10.1258/om.2012.110014; PMid:27582863 PMCid:PMC4989704

9. Alonso A. Recent use of oral contraceptives and the risk of multiple sclerosis / A. Alonso, S. Jick, M. Olek [et al.] // Arch Neurol .– 2005.– V. 62(9).– P. 1362–1365. https://doi.org/10.1001/archneur.62.9.1362; PMid:16157743

10. Alonso A. Temporal trends in the incidence of multiple sclerosis: a systematic review / A. Alonso, M. Hernan // Neurology.– 2008.– V. 71(2).– P. 129–135. https://doi.org/10.1212/01.wnl.0000316802.35974.34; PMid:18606967 PMCid:PMC4109189

11. Amato M. Pregnancy and fetal outcomes after interferon-b exposure in multiple sclerosis / M. Amato, E. Portaccio, A. Ghezzi [et al.] // Neurology.– 2010.– V. 75.– P. 1794–1802. https://doi.org/10.1212/WNL.0b013e3181fd62bb; PMid:21079181

12. Amato M. Fertility, Pregnancy and Childbirth in Patients with Multiple Sclerosis: Impact of Disease-Modifying Drugs / M. Amato, E. Portaccio // CNS Drugs.– 2015.– V. 29(3).– P. 207–220. https://doi.org/10.1007/s40263-015-0238-y; PMid:25773609

13. Bamford C. Anesthesia in multiple sclerosis / C. Bamford, W. Sibley, J. Laguna // Can J Neurol Sci.– 1978.– V. 5.– P. 41–44. PMid:647496

14. Borchers A. The implications of autoimmunity and pregnancy / A. Borchers, S. Naguwa, C. Keen [et al.] // J Autoimmun.– 2010.– V. 34(3).– P. 287–299. https://doi.org/10.1016/j.jaut.2009.11.015; PMid:20031371

15. Bronner G. Female sexuality in multiple sclerosis: the multidimensional nature of the problem and the intervention / G. Bronner, E. Elran // Acta Neurol Scandinavica.– 2010.– V. 121(5).– P. 289–301. https://doi.org/10.1111/j.1600-0404.2009.01314.x; PMid:20070276

16. Bove R. The role of gender and sex hormones in determining the onset and outcome of multiple sclerosis / R. Bove, T. Chitnis // Mult Scler.– 2014.– V. 20(5).– P. 520–526. https://doi.org/10.1177/1352458513519181; PMid:24561324

17. Confavreux C. Rate of pregnancy-related relapse in multiple sclerosis. Pregnancy in Multiple Sclerosis Group / C. Confavreux, M. Hutchinson, M. Hours [et al.] // N Engl J Med.– 1998.– V. 339(5).– P. 285–291. https://doi.org/10.1056/NEJM199807303390501; PMid:9682040

18. Correale J. Increase in multiple sclerosis activity after assisted reproduction technology / J. Correale, M. Farez, M. Ysrraelit // Ann Neurol.– 2012.– V. 72(5).– P. 682–694. https://doi.org/10.1002/ana.23745; PMid:23034952

19. Dahl J. Pregnancy, delivery, and birth outcome in women with multiple sclerosis / J. Dahl, K. Myhr, A. Daltveit [et al.] // Neurology.– 2005.– V. 65.– P. 1961–1963. https://doi.org/10.1212/01.wnl.0000188898.02018.95; PMid:16380620

20. D’hooghe M. Menarche, oral contraceptives, pregnancy and progression of disability in relapsing onset and progressive onset multiple sclerosis / M. D’hooghe, P. Haentjens, G. Nagels [et al.] // J Neurol.– 2012.– V. 259(5).– P. 855–861. https://doi.org/10.1007/s00415-011-6267-7; PMid:21993617

21. Heras De Las Pregnancy in multiple sclerosis patients treated with immunomodulators prior to or during part of the pregnancy: a descriptive study in the Spanish population. / De Las Heras, De C. Andres, N. Tellez [et al.] // Mult Scler .– 2007.– V. 13.– P. 981–984. https://doi.org/10.1177/1352458507077896; PMid:17623725

22. Demirkiran M. Multiple sclerosis patients with and without sexual dysfunction: are there any differences? / M. Demirkiran, Y. Sarica, S. Uguz [et al.] // Mult Scler .– 2006.– V. 12.– P. 209–214. https://doi.org/10.1191/135248506ms1253oa

23. Falaschi P. High incidence of hyperandrogenism-related clinical signs in patients with multiple sclerosis / P. Falaschi, A. Martocchia, A. Proietti [et al.] // Neuro Endocrinol Lett. .– 2001.– V. 22(4).– P. 248–250. PMid:11524631

24. Gava G. Long-term influence of combined oral contraceptive use on the clinical course of relapsing–remitting multiple sclerosis / G. Gava, I. Bartolomei, A. Costantino [et al.] // Fertil Steril .– 2014.– V. 102(1).– P. 116–122. https://doi.org/10.1016/j.fertnstert.2014.03.054; PMid:24794311

25. Finkelsztejn A. What can we really tell women with multiple sclerosis regarding pregnancy? A systematic review and meta-analysis of the literature / A. Finkelsztejn, J. Brooks, F. Jr. Paschoal [et al.] // BJOG.– 2011.– V. 118(7).– P. 790–797. https://doi.org/10.1111/j.1471-0528.2011.02931.x

26. Gilli F. Learning from nature: pregnancy changes the expression of inflammation-related genes in patients with multiple sclerosis / F. Gilli, R. Lindberg, P. Valentino [et al.] // PLoS One.– 2010.– V. 5(1).– P. 8962. https://doi.org/10.1371/journal.pone.0008962; PMid:20126412 PMCid:PMC2813302

27. Grinsted L. Serum sex hormone and gonadotropin concentrations in premenopausal women with multiple sclerosis / L. Grinsted, A. Heltberg, C. Hagen [et al.] // J Intern Med .– 1989.– V. 226(4).– P. 241. https://doi.org/10.1111/j.1365-2796.1989.tb01387.x; PMid:2809499

28. Hellwig K. Artificial reproductive techniques in multiple sclerosis / K. Hellwig, J. Correale // Clin Immunol.– 2013.– V. 149(2).– P. 219–224. https://doi.org/10.1016/j.clim.2013.02.001; PMid:23507401

29. Hellwig K. Increase in relapse rate during assisted reproduction technique in patients with multiple sclerosis / K. Hellwig, S. Schimrigk, C. Beste [et al.] // Eur Neurol.– 2009.– V. 61(2).– P. 65–68. https://doi.org/10.1159/000177937; PMid:19039223

30. Hernan M. Oral contraceptives and the incidence of multiple sclerosis / M. Hernan, M. Hohol, M. Olek [et al.] // Neurology .– 2000.– V. 55(6).– P. 848–854. https://doi.org/10.1212/WNL.55.6.848; PMid:10994007

31. Holmqvist P. Age at onset of multiple sclerosis is correlated to use of combined oral contraceptives and childbirth before diagnosis / P. Holmqvist, M. Hammar, A. Landtblom [et al.] // Fertil Steril.– 2010.– V. 94(7).– P. 2835–2837. https://doi.org/10.1016/j.fertnstert.2010.06.045; PMid:20807659

32. Holmqvist P. Symptoms of multiple sclerosis in women in relation to cyclical hormone changes / P. Holmqvist, M. Hammar, A. Landtblom [et al.] // Eur J Contracept Reprod Health Care.– 2009.– V. 14(5).– P. 365–370. https://doi.org/10.3109/13625180903137329; PMid:19916763

33. Kempe P. Symptoms of multiple sclerosis during use of combined hormonal contraception / P. Kempe, M. Hammar, J. Brynhildsen // Eur J Obstet Gynecol Reprod Biol.– 2015.– V. 193.– P. 1–4. https://doi.org/10.1016/j.ejogrb.2015.06.030; PMid:26196655

34. Jalkanen A. Pregnancy outcome in women with multiple sclerosis – results from a prospective nationwide study in Finland / A. Jalkanen, A. Alanen, L. Airas // Mult Scler.– 2010.– V. 16.– P. 950–955. https://doi.org/10.1177/1352458510372629; PMid:20542921

35. Laumann E. A population-based survey of sexual activity, sexual problems and associated help-seeking behavior patterns in mature adults in the United States of America / E. Laumann, D. Glasser, R. Neves [et al.] // Int J Impot Res .– 2009.– V. 21.– P. 171–178. https://doi.org/10.1038/ijir.2009.7; PMid:19242482

36. Michel L. Increased risk of multiple sclerosis relapse after in vitro fertilisation / L. Michel, Y. Foucher, S. Vukusic [et al.] // J Neurol Neurosurg Psychiatry.– 2013.– V. 83(8).– P. 796–802. https://doi.org/10.1136/jnnp-2012-302235; PMid:22693287

37. Combe Mc P. Female reproductive issues in multiple sclerosis / Mc P. Combe, J. Greer // Mult Scler.– 2012.– V. 19(4).– P. 392–402. https://doi.org/10.1177/1352458512452331; PMid:22733837

38. Moreira E. Sexual problems and help-seeking behaviour in adults in the United Kingdom and continental Europe / E. Moreira, D. Glasser, A. Nicolosi [et al.] // BJU Int .– 2008.– V. 101.– P. 1005–1011. https://doi.org/10.1111/j.1464-410X.2008.07453.x; PMid:18261155

39. Mueller B. Birth outcomes and need for hospitalization after delivery among women with multiple sclerosis / B. Mueller, J. Zhang, C. Critchlow // Am J Obstet Gynecol .– 2002.– V. 186.– P. 446–452. https://doi.org/10.1067/mob.2002.120502; PMid:11904605

40. Neill J. Knobil and Neill’s physiology of reproduction / Neill J. , Knobil E. New York: Academic Press, 2005.

41. Orton S. Sex ratio of multiple sclerosis in Canada: a longitudinal study / S. Orton, B. Herrera, I. Yee [et al.] // Lancet Neurol.– 2006.– V. 5(11).– P. 932–936. https://doi.org/10.1016/S1474-4422(06)70581-6

42. Ortona E. Sex-based differences in autoimmune diseases / E. Ortona, M. Pierdomonici, A. Maselli // Annali dell’Istituto Superiore di Sanitа.– 2016.– V. 52(2).– P. 205–212. PMid:27364395

43. Pasto L. Epidural analgesia and cesarean delivery in multiple sclerosis post-partum relapses: the Italian cohort study / L. Pasto, E. Portaccio, A. Ghezzi [et al.] // BMC Neurol.– 2012.– V. 12.– P. 165. https://doi.org/10.1186/1471-2377-12-165; PMid:23276328 PMCid:PMC3544735

44. Patti F. Is in utero early-exposure to interferon beta a risk factor for pregnancy outcomes in multiple sclerosis? / F. Patti, T. Cavallaro, Lo S. Fermo // J Neurol .– 2008.– V. 255.– P. 1250–1253. https://doi.org/10.1007/s00415-008-0909-4; PMid:18677640

45. Pierdominici M. Estrogen receptor pro les in human peripheral blood lymphocytes / M. Pierdominici, A. Maselli, T. Colasanti // Immunol Lett.– 2010.– V. 132(1-2).– P. 79–85. https://doi.org/10.1016/j.imlet.2010.06.003; PMid:20542061

46. Portaccio E. Breastfeeding is not related to postpartum relapses in multiple sclerosis / E. Portaccio, A. Ghezzi, B. Hakiki [et al.] // Neurology.– 2011.– V. 77(2).– P. 145–150. https://doi.org/10.1212/WNL.0b013e318224afc9; PMid:21734184

47. Portaccio E. Postpartum relapses increase the risk of dis- ability progression in multiple sclerosis: the role of disease modifying drugs / E. Portaccio, A. Ghezzi, B. Hakiki [et al.] // J Neurol Neurosurg Psychiatry.– 2014.– V. 85(8).– P. 845–850. https://doi.org/10.1136/jnnp-2013-306054; PMid:24403285

48. Poser S. Pregnancy, oral contraceptives and multiple sclerosis / S. Poser, N. Raun, J. Wikstrom [et al.] // Acta Neurol Scand .– 1979.– V. 59(2-3).– P. 108–118. https://doi.org/10.1111/j.1600-0404.1979.tb02917.x

49. Prieto G. Oestradiol potentiates the suppressive function of human CD4/CD25 regulatory T cells by promoting their proliferation / G. Prieto, Y. Rosenstein // Immunology.– 2006.– V. 118(1).– P. 58–65. https://doi.org/10.1111/j.1365-2567.2006.02339.x; PMid:16630023 PMCid:PMC1782269

50. Ramagopalan S. Age of puberty and the risk of multiple sclerosis: a population based study / S. Ramagopalan, W. Valdar, M. Criscuoli [et al.] // Eur J Neurol .– 2009.– V. 16(3).– P. 342–347. https://doi.org/10.1111/j.1468-1331.2008.02431.x; PMid:19170744

51. Rosen R. Assessment of female sexual dysfunction: review of validated methods / R. Rosen // Fertil Steril.– 2002.– V. 77(4).– P. 89–93. https://doi.org/10.1016/S0015-0282(02)02966-7

52. Salminen H. Glatiramer acetate exposure in pregnancy: preliminary safety and birth outcomes / H. Salminen, H. Leggett, M. Boggild // J Neurol. – 2010.– V. 257.– P. 2020–2023. https://doi.org/10.1007/s00415-010-5652-y; PMid:20625758

53. Sandberg-Wollheim M. Pregnancy outcomes in multiple sclerosis following subcutaneous interferon beta-1a therapy / M. Sandberg-Wollheim, E. Alteri, Stam M. Moraga [et al.] // Mult Scler .– 2011.– V. 17.– P. 423–430. https://doi.org/10.1177/1352458510394610; PMid:21220368

54. Sandberg-Wollheim M. Pregnancy outcomes during treatment with interferon beta-1a in patients with multiple sclerosis. / M. Sandberg-Wollheim, D. Frank, T. Goodwin // Neurology.– 2005.– V. 65(6).– P. 802–806. https://doi.org/10.1212/01.wnl.0000168905.97207.d0; PMid:16093457

55. Sena A. Oral contraceptive use and clinical outcomes in patients with multiple sclerosis / A. Sena, R. Couderc, J. Vasconcelos et al. // J Neurol Sci.– 2012.– V. 317(1-2).– P. 47–51. https://doi.org/10.1016/j.jns.2012.02.033; PMid:22459356

56. Shelly S. Prolactin and autoimmunity / S. Shelly, M. Boaz, H. Orbach // Autoimmun Rev .– 2012.– V. 11(6-7).– P. 465–470. https://doi.org/10.1016/j.autrev.2011.11.009; PMid:22155203

57. Stenager E. Sexual function in multiple sclerosis: a 5-year follow-up study / E. Stenager, E. Stenager, K. Jensen // Ital J Neurol Sci .– 1996.– V. 17.– P. 67–69. https://doi.org/10.1007/BF01995711; PMid:8742990

58. Sloka J. The relation between menarche and the age of first symptoms in a multiple sclerosis cohort / J. Sloka, W. Pryse-Phillips, M. Stefanelli // Mult Scler .– 2006.– V. 12(3).– P. 333–339. https://doi.org/10.1191/135248506ms1267oa; PMid:16764348

59. Tan I. Hormonal modulation of the immune system — A spotlight on the role of progestogens / I. Tan, E. Peeva, G. Zandman-Goddard // Autoimmun Rev .– 2015.– V. 14(6).– P. 536–542. https://doi.org/10.1016/j.autrev.2015.02.004; PMid:25697984

60. Thone J. Serum anti-Mullerian hormone levels in reproductive- age women with relapsing–remitting multiple sclerosis / J. Thone, S. Kollar, D. Nousome // Mult Scler.– 2015.– V. 21(1).– P. 41–47. https://doi.org/10.1177/1352458514540843; PMid:25145691

61. Thorogood M. The influence of oral contraceptives on the risk of multiple sclerosis / M. Thorogood, P. Hannaford // Br J Obstetr Gynaecol .– 1998.– V. 105(12).– P. 1296–1299. https://doi.org/10.1111/j.1471-0528.1998.tb10008.x; PMid:9883921

62. Trigunaite A. Suppressive effects of androgens on the immune system / A. Trigunaite, J. Dimo, T. Jorgensen // Cell Immunol.– 2015.– V. 294(2).– P. 87–94. https://doi.org/10.1016/j.cellimm.2015.02.004; PMid:25708485

63. Voskuhl R. Estriol combined with glatiramer acetate for women with relapsing-remit- ting multiple sclerosis: a randomised, placebo-controlled, phase 2 trial / R. Voskuhl, H. Wang // Lancet Neurol.– 2016.– V. 15(1).– P. 35–46. https://doi.org/10.1016/S1474-4422(15)00322-1

64. Vukusic S. Pregnancy and multiple sclerosis (the PRIMS study): clinical predictors of post-partum relapse / S. Vukusic, M. Hutchinson, M. Hours // Brain.– 2004.– V. 127(6).– P. 1353–1360. https://doi.org/10.1093/brain/awh152

65. Zandman-Goddard G. Gender and autoimmunity / G. Zandman-Goddard, E. Peeva, Y. Shoenfeld // Autoimmun Rev .– 2007.– V. 6.– P. 366–372. https://doi.org/10.1016/j.autrev.2006.10.001; PMid:17537382

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