SOVREMENNAYA PEDIATRIYA.2016.4(76):47-56; doi10.15574/SP.2016.76.47

Развитие иммунного ответа при пневмококковой пневмонии (часть 1) 

Абатуров А. Е., Никулина А. А., Петренко Л. Л.

ГУ «Днепропетровская медицинская академия МЗ Украины», г. Днепр, Украина 

В статье представлена роль пневмококковой инфекции в структуре острых бактериально ассоциированных заболеваний респираторного тракта у детей и механизмы формирования иммунного ответа, направленные на эрадикацию внеклеточного возбудителя. На основании анализа литературных источников дано современное представление о функционировании молекулярних механизмов рекогниции пневмококковых патоген-ассоциированных молекулярных структур и индукции внутриклеточных сигнальных путей возбуждения эффекторных клеток респіраторного тракта. Продемонстрировано, что для инициации воспалительного процесса при пневмококковой инфекции необходимо, как минимум, два сигнала, один из которых активирует образ-распознающие рецепторы, а второй обуславливает формирование и активацию инфламмасомы.

Ключевые слова: пневмония, Streptococcus pneumoniae, дети, иммунный ответ, PRR, инфламмасома.

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