• Перинатальные аспекты формирования иммунного статуса ребенка

Перинатальные аспекты формирования иммунного статуса ребенка

PERINATOLOGIYA I PEDIATRIYA. 2017.1(69):95-102; doi 10.15574/PP.2017.69.95

Перинатальные аспекты формирования иммунного статуса ребенка

Макаренко М. В., Говсеев Д. А., Берестовой В. О., Сокол И. В., Ворона Р. М.
Киевский городской родильный дом № 5, Украина

Цель — обобщены литературные материалы за последние 30 лет о современных представлениях относительно иммунологических аспектов в формировании и функционировании системы «мать—плацента—плод»; уделить особое внимание формированию иммунной системы плода (Иммункулус) в зависимости от материнской иммунной нагрузки.

Пациенты и методы. Приведены результаты обследования 19 рожениц и кордовой крови их новорожденных детей в зависимости от срока беременности. Определено содержание в крови антител классов IgG и IgM. В качестве антигена использован HSP60 человека.

Полученные результаты свидетельствуют о формировании иммунного статуса плода при беременности за счет материнских антигенов, включая IgG. Под их влиянием плод формирует аутоантитела класса IgM для быстрой презентации и распознавания антигенов внешней среды.

Выводы. Высказано предположение про возможный механизм возникновения преждевременных родов.

Ключевые слова: Иммункулус, IgG и IgM, аутоантитела, эпигенетический иммунный импринтинг, HSP60.

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