• The value of risk factors in infertile men in the aspect of choice of assisted reproductive technologies to renew fertility in married couples

The value of risk factors in infertile men in the aspect of choice of assisted reproductive technologies to renew fertility in married couples

 

HEALTH OF WOMAN. 2016.10(116):136–139; doi 10.15574/HW.2016.116.136 
 

The value of risk factors in infertile men in the aspect of choice of assisted reproductive technologies to renew fertility in married couples


Gurzhenko Yu. N., Kutsenko A. O.

National Medical Academy of Postgraduate Education P. L. Shupyk, Kiev


The objective: the rationalization of a personalized approach to the selection of the program art on the basis of the allocation of risk.


Patients and methods. Were analyzed 180 couples with male factor infertility, which in 2012-2015, in the Institute of reproductive medicine (IRM) (Kiev) was held the program of intracytoplasmic sperm injection (ICSI) with the aim of restoring fertility. Examination and ICSI procedure is carried out in accordance with clinical protocols.


Results. According to the results of analytical and synthetic analysis of primary documents (enhanced, adapted to the purpose of the work of the medical record) were identified risk factors (and their signs) for the development of male infertility and grouped by direction of impact. As a result, 25 of the 51 factors and their basis formed three groups: social (behavioral), biological/clinical and special medical. With the help of mathematical analysis it was determined the boundary values of the minimum and maximum of reliability of the negative result of the application of ART.


Conclusion. It was proposed the predictive map for the determination of the probability of pregnancy in couples with male infertility problems with the application of ART. Was justified the separation of three risk groups to restore fertility in couples with male factor infertility using ART. Was based the principle of personalized approach to choosing the best program of art-based stratification of men at risk groups.


Key words: male infertility, assisted reproductive technologies, risk factors, prognostic chart.


REFERENCES

1. Alyaev YuG, Grigoryan VA, Chalyiy ME. 2006. Narusheniya polovoy i reproduktivnoy funktsii u muzhchin. Moskva, Litera:52–96.

2. Bragina EE. 2002. Rukovodstvo po spermatologii. Pod red. EE Braginoy, RA Abdumalikovoy. Moskva, Meditsina:93.

3. Golyachenko OM, Serdyuk AM, Prihodskiy OO. 1997. Sotsialna meditsina: organizatsiya ta ekonomika ohoroni zdorov’ya. Ternopil; Kiyiv, Vinnitsya:328.

4. Gorpinchenko II, Nurimanov KR, Poroshina TV, Savchenko VS, Drannik GN. 2016. Problemyi idiopaticheskogo muzhskogo besplodiya. Zdorove muzhchiny 1:133–136.

5. Dahno FV. 2011. Bezpliddya v Ukrayini: analiz situatsiyi. Zdorov’ya Ukrayini 4:10–14.

6. Komissarova YuV. 2010. Optimizatsiya programmyi EKO i perenosa embrionov s uchetom angiogennyih faktorov. Avtoref. diss. kand. med. nauk: 14.00.01 Akusherstvo i ginekologiya. M:26.

7. Malyishkina AI, Fetisova IN, Lipin MA. 2012. Polimorfizm genov sistemyi detoksikatsii v supruzheskih parah, uchastvuyuschih v programme ekstrakorporalnogo oplodotvoreniya. Detskaya meditsina Severo-Zapada 3;2:24–26.

8. Chalyiy ME, Ahvlediani ND, Harchilova RR. 2016. Muzhskoe besplodie. Urologiya (prilozhenie). 1:2–16.

9. Bahadur G, Homburg R, Muneer A, Racich P et al. 2016. First line fertility treatment strategies regarding IUI and IVF require clinical evidence. Hum Reprod. 31(6):1141–6. https://doi.org/10.1093/humrep/dew075; PMid:27076499

10. Ferrer-Vaquer A, Barragan M, Freour T, Vernaeve V et al. 2016. PLC sequence, protein levels, and distribution in human sperm do not correlate with semen characteristics and fertilization rates after ICSI. J. Assist Reprod. Genet. 33(6):747–56. https://doi.org/10.1007/s10815-016-0718-0; PMid:27138933

11. Klement AH, Koren-Morag N, Itsykson P, Berkovitz A. 2013. Intracytoplasmic morphologically selected sperm injection versus intracytoplasmic sperm injection: a step toward a clinical algorithm. Fertil. Steril. 99(5):1290–3. https://doi.org/10.1016/j.fertnstert.2012.12.020; PMid:23357455

12. Marci R, Murisier F, Lo Monte G, Soave I et al. 2013. Clinical outcome after IMSI procedure in an unselected infertile population: a pilot study. Reprod. Health. 22:10–16. https://doi.org/10.1186/1742-4755-10-16

13. Muratori M, Tarozzi N, Cambi M, Boni L et al. 2016. Variation of DNA Fragmentation Levels During Density Gradient Sperm Selection for Assisted Reproduction Techniques: A Possible New Male Predictive Parameter of Pregnancy? Medicine (Baltimore). 95(20):3624. https://doi.org/10.1097/MD.0000000000003624; PMid:27196465 PMCid:PMC4902407

14. Simon L, Wilcox A, Carrell DT. 2013. Intracytoplasmic morphology-selected sperm injection. Methods Mol. Biol. 927:247–56. https://doi.org/10.1007/978-1-62703-038-0_22; PMid:22992919

15. Zagarskikh EYu, Labygina AV, Kurashova NA. 2014. Experience in the treatment of normogonadotropic infertility in men. Urolog. 5:87–89.