• The safety of use of selective beta-blockers during the pregnancy (experimental studies) 

The safety of use of selective beta-blockers during the pregnancy (experimental studies) 

PERINATOLOGIYA I PEDIATRIYA. 2016.2(66):18-21; doi 10.15574/PP.2016.66.18 
 

The safety of use of selective beta-blockers during the pregnancy (experimental studies) 
 

Limanskaia A. Yu., Davydova Yu. V.

SI «Institute of Pediatrics, Obstetrics and Gynecology NAMS of Ukraine», Kiev 
 

The effect of «Biprolol» selective preparation on the tone and contractile activity of the myometrium of pregnant rats is examined. Experimental studies have shown that cardioselective agents such as «Biprolol» lower bind with β2-receptors and thereby not cause the tone of pregnant uterus. 
 

Key words: selective beta-blockers, pregnancy, experimental research. 
 

REFERENCES

1. Abalos E, Duley L, Steyn DW et al. 2007, Jan 24. Cochrane Database Syst Rev. (1): CD002252. PMid:17253478

2. Calvert MJ, Shankar A, McManus RJ et al. 2009, Jan 18. Evaluation of the management of heart failure in primary care. Fam Pract. PubMed — as supplied by publisher.

3. Groote P, Isnard R, Clerson P et al. 2009. Eur J Heart Fail. 11(1): 85—91. http://dx.doi.org/10.1093/eurjhf/hfn005; PMid:19147461

4. Magee LA, Duley L. 2003. Oral beta-blockers for mild to moderate hypertension during pregnancy. Cochrane Database of Systematic Reviews. Issue 3. Art. No.: CD002863. http://dx.doi.org/10.1002/14651858.CD002863.

5. Wehling M. 2010. Multimorbidity and polypharmacy: which betablocker to use in relation to the pharmacokinetic profile and interaction potential. Arzneimittelforschung. 60(2): 57—63. PMid:20329652