• The modern features of pathogenesis1induced prevention of preeclampsia 

The modern features of pathogenesis1induced prevention of preeclampsia 

PERINATOLOGIYA I PEDIATRIYA.2016.1(65):46-50;doi 10.15574/PP.2016.65.46 

The modern features of pathogenesis1induced prevention of preeclampsia 

Konkov D. G., Bulavenko O. V., Dudnik V. M., Buran V. V.

Vinnytsya National Pirogov Memorial Medical University, Vinnytsya, Ukraine 

Purpose — the assessment of clinical effectiveness of preventive therapy in pregnant women with high risk of preeclampsia. 

Patients and methods. In the comparative study on the effectiveness of preventive therapy were participated 110 pregnant women with decidual vasculopathy and endothelial dysfunction, which had high risk of preeclampsia. We investigated the clinical efficacy for medications that containing 75 mg of acetylsalicylic acid and L-arginine. 

Results. The results of the study have shown that use of preventive treatment (L-arginine and acetylsalicylic acid) from 12 weeks, among pregnant women with high risk of preeclampsia, led to a significant decrease of perinatal loss, reduction of clinical manifestations of preeclampsia, preterm delivery, malformations and malpresentation of the placenta, cases of asphyxia of the newborns, perinatal CNS lesions and intra-ventricular hemorrhage. 

Conclusions. Clinical effectiveness of preventive treatment (L-arginine and ASA) among pregnant women with high risk of preeclampsia was proven. Furthermore it was recognized clinically effective use of 75 mg of ASA from 12 weeks of pregnancy. No side effects of drugs in the study were noted. 

Key words: preeclampsia, endothelial dysfunction, acetylsalicylic acid, L-arginine. 


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