• Role of hyperprolactinemia in the genesis of premature thelarche and its correction in girls, during the first five years of life 

Role of hyperprolactinemia in the genesis of premature thelarche and its correction in girls, during the first five years of life 

HEALTH OF WOMAN. 2016.4(110):160–162; doi 10.15574/HW.2016.110.160 
 

Role of hyperprolactinemia in the genesis of premature thelarche and its correction in girls, during the first five years of life 
 

Maltseva O. I.

MI «Dnipropetrovsk regional perinatal center with a hospital» DRC 
 

The aim of the research: to study the effect of the drug Cyclodynon® on girls with an incomplete form of precocious puberty in tosexualize type – isolated thelarche on the background of increased levels of prolactin (ILP).


The materials and methods. A survey was conducted in 30 girls aged from 1 to 5 years with isolated premature thelarche. Clinical ultrasound and hormonal studies were conducted. All patients were examined by the endocrinologist, neurologist and pediatrician. Girls with isolated thelarche and a high level of ILP were prescribed the drug Cyclodynon® depending on the age and level of ILP in serum at a dose of 1/8 tablet to 1 tablet (or 5 drops to 40 drops) in the morning on an empty stomach once a day.


Results. In the study, where were included 30 girls with isolated thelarche revealed a stable increase in the level of ILP (up to 680 Miu/l while normal values diameter 110-400 Miu/l) with relatively normal levels of gonadotropins and estradiol. The use of the drug is a special extract of Vitex Agnus Castus – Cyclodynon® contributed to a gradual, over 3 months, reducing the level to normal of ILP values up to 680 396 Miu/L. the Decrease in the level of ILP was correlated with regression of clinical signs of thelarche. Adverse or desirable effects when applying Cyclodynon® for 3 months were noted.


Conclusion. In children during the first five years of life in the genesis of isolated thelarche significant role is played by the increased level of ILP in serum. The use of standardized herbal drug Cyclodynon® with dopaminergic effect contributes to the normalization of the ILP level to treat girls with an incomplete form of precocious puberty in tosexualize type – isolated, thelarche on the background of elevated levels of ILP is an effective and pathogenetically justified. This is confirmed by the results of clinical and hormonal studies.


Key words: isolated thelarche, prolactin, Cyclodynon®.


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