• Risk Factors of the Development of Interstitial Lung Diseases in Children with Trisomy 21

Risk Factors of the Development of Interstitial Lung Diseases in Children with Trisomy 21

SOVREMENNAYA PEDIATRIYA.2017.4(84):62-65; doi 10.15574/SP.2017.84.62

Gonchar' M.O., Logvinova O. L., Muratov G. R., Yablons'ka N. M., Pomazunovs'ka O. P., Tsura O. M.
Kharkiv National Medical University, Ukraine
Communal Healthcare Institution Kharkiv Regional Children's Clinical Hospital, Ukraine

Objective: to improve the diagnosis of children's interstitial lung disease (chILD) in patients with trisomy 21 by determination and clustering the risk factors of a disease.

Material and methods. The 37 children with a trisomy of 21, among them 14 (37.8%) with chILD (the main group) and 23 (62.1%) without chILD (the comparison group), were observed. An average age of patients of the main group was 9.7±2.4 months, and in the comparison group — 11.2±3.6 months (r>0.05). Examination of children was conducted during the period from 2007 till 2016 at the Department of pediatrics No. 1 and the Department of neonatology of the Kharkiv National Medical University based on Kharkiv Regional Children's Hospital.

Results. When analyzing the maternal obstetric history of the main group related to respiratory disease, the latter made up 6.7±1.7%. In the ІІ trimester of pregnancy the acute respiratory disease was observed in 85.7% of the main group mothers that indicated statistically significant increased incidence (r<0.05).

The influence of an acute respiratory disease in the ІІ trimester of pregnancy on the formation of chILD was proved (DI 0.37–0.79; F (1.247)=3.93; p=0.049). The 2nd trimester of pregnancy is a the period of the formation of channels in a pulmonary mesenchyme, and completion of terminal bronchioles and acinuses development.

Conclusions. The key aspects regarding the chILD formation in children with trisomy 21 were complex heart defects or other congenital heart defects with increased pulmonary blood flow, using of the artificial blood-circulation bypass and long-term artificial lung ventilation (>7 days) during cardiovascular operation. The burdened perinatal history (acute respiratory infection in the ІІ trimester of pregnancy, congenital pneumonia in neonate) and cytomegalovirus infection in child's medical history had less clustered implication in formation of chILD in children with trisomy 21.

Key words: interstitial lung disease, risk factors, children, trisomy of 21 chromosomes.


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