• Restoring the balance of vaginal and intestinal biotopes in preconceptional period after antibiotic therapy

Restoring the balance of vaginal and intestinal biotopes in preconceptional period after antibiotic therapy

PERINATOLOGIYA I PEDIATRIYA. 2017.1(69):33-38; doi 10.15574/PP.2017.69.33

Restoring the balance of vaginal and intestinal biotopes in preconceptional period after antibiotic therapy

Limanskaya A. Yu., Voloshyna T. V., Baider A. K., Davydova I. V.

SI «Institute of Pediatrics, Obstetrics and Gynecology of NAMS of Ukraine», Kyiv

Military Medical Directorate of the Security Service of Ukraine, Kyiv

Actuality. Clinical effects of antibiotic therapy are confirmed by the emergence of many pathological conditions, allergies, diarrhea, irritable bowel syndrome, inflammatory bowel disease, colorectal cancer. Widespread bacterial vaginosis and other vaginal infectious diseases, accompanied by significant violations microbiocenosis (mainly a decrease in the total lactobacilli number) have necessitated alternative methods of treatment. Regarding the properties of influence on the microflora and mechanism of therapeutic action, the most physiological medicines are considered to be living bacteria of normal biocenosis, with no observable adverse events by contrast to chemical eubiotics.

Objective — to determine the efficiency of symbiotic «Laktiale» to normalize the intestine and vaginal microbiocenosis after antibiotic therapy as part of preconception preparation of women.

Materials and methods. We examined 43 women with autoimmune disorders requiring antibiotics preconception administration. In general, women received Ceftriaxone and Amoxicillin with Clavulanic acid in therapeutic doses. The survey was conducted immediately after the end of antibiotic therapy and with one week interval.

Results. Normalization of lactoflora during the preconception period is essential in the prevention of bacterial vaginosis, which causes the preterm birth, especially if bacterial vaginosis is recorded in the first 16 weeks of pregnancy. Physiological balance of mother's intestinal microflora influences on the physiological development of immune system of the fetus, which greatly increases, in its turn, the ability to resist pathogens.

Conclusions. Administration of symbiotic significantly reduces the incidence rate of symptoms and duration of diarrhea. This effect is explained by the normalization of intestinal microbiota in women who are treated with "Laktiale" due to the maintenance of functional intestinal microbiota (the presence of lactobacilli in the appropriate quantity and no contamination of intestine).

Key words: bacterial vaginosis, dysbiosis, antibiotics, probiotics, diarrhea, microflora, immunity, Clostridium difficile.

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