HEALTH OF WOMAN WH_№4_2014
Galych S. R.
Dysmenorrhea: pathogenesis, clinical picture, treatment.
The article is dedicated to the relevant aspects of dysmenorrhea’s neuroendocrine syndrome. The data from the literature and valid classification is presented. The principal branches of pathogenesis of primary and secondary dysmenorrhea are illustrated. Clinical manifestations are described. Additionally, own data on the participation of dysmenorrhea in shaping individual response of the patient to the pain and the impact of «painful anamnesis» on the choice of the labor anesthesia are introduced. The pathogenetically based ways of treatment are discussed. The data on the effectiveness of using non-steroidal anti;inflammatory drugs (NSAIDs), antispasmodics, hormones are examined. Personal experience in application of the rectal form of NSAID – dikloberl drug by 114 patients with dysmenorrhea is analyzed. There are demonstrated the high efficiency of the drug. An additional effect during the dikloberl therapy is a significant decrease in reactive anxiety index (RA) after a month of the treatment (p<0,05) and no significant differences in the RA index for healthy women after 3 months of the treatment (p>0,05). The effect lasted for 6 months after the cessation of the therapy.
Key words: dysmenorrhea, non-steroidal anti-inflammatory drugs, dikloberl.
Проведение фармакотерапии в период беременности: опасность в квадрате или способ защитить будущее?
Особое место в перечне мероприятий форума занял семинар «Болезни почек и беременность», в рамках которого на двух пленарных заседаниях ведущими экспертами страны обсуждались различные актуальные и дискутабельные темы: физиологические изменения мочевыделительной системы и водно-электролитного гомеостаза в период беременности (БН); принципы и подходы к ведению беременных с сопутствующей нефрологической патологией; вопросы профилактики, диагностики и лечения инфекционных заболеваний мочевыделительной системы у этой категории пациенток; проблема отеков в период гестации; тактика ведения БН и родов у женщин с единственной, а также с трансплантированной почкой, находящихся на гемо- или перитонеальном диализе, имеющих сопутствующую патологию (гломерулонефрит, сахарный диабет, преэклампсию); особенности пренатальной диагностики врожденной и наследственной патологии почек.
Stevenson John C., Durand Gemma, Kahler Elke, Pertynski Tomasz
Oral ultra-low dose continuous combined hormone replacement therapy with 0,5mg 17β-oestradiol and 2,5mg dydrogesterone for the treatment of vasomotor symptoms: Results from a double-blind, controlled study.
Objectives: Guidelines recommend using the lowest effective dose of oestrogen for the management of vasomotor symptoms in postmenopausal women. The primary aim of this double-blind, multi-centre, randomised study was to assess the efficacy of oral ultra-low dose continuous combined hormone replacement therapy with 17β-oestradiol and dydrogesterone.
Study design: 313 women with ≥50 moderate to severe hot flushes during the previous week were randomised to 0,5mg 17β-oestradiol/2,5mg dydrogesterone (E 0,5 mg/D 2,5 mg), 1mg 17β-oestradiol/5mg dydrogesterone (E 1 mg/D 5 mg) or placebo for 13 weeks. The placebo group then switched to E 0,5 mg/D 2,5 mg for a further 39 weeks, whilst the other groups continued on the same treatment.
Results: After 13 weeks, the reduction in the number of moderate to severe hot flushes/day in the E 0,5 mg/D 2,5mg group was greater than in the placebo group (-6,4 vs. -4,9, p < 0,001) and comparable
to that in the 1/5mg group (-6,3). E 0,5 mg/D 2,5mg and E 1 mg/D 5mg significantly improved the total Menopause Rating Scale score. The number of bleeding/spotting days was lower with E 0,5 mg/D 2,5mg than with E 1 mg/D 5 mg. The overall amenorrhoea rate with E 0,5 mg/D 2,5mg was 81%; this increased to 91% in months 10–12.
Conclusions: Continuous combined 0,5mg 17β-estradiol and 2,5mg dydrogesterone was effective in alleviating vasomotor symptoms and improving quality of life, and was associated with a high amenorrhoea rate and a good tolerability profile.
Key words: Hormone replacement therapy, Oestradiol, Dydrogesterone, Postmenopausal, Vasomotor symptoms, Ultra-low dose.
Pyrohova V., Shurpyak S., Malachynska M.
Varicose veins of the pelvis and chronic pelvic pain syndrome – diagnostic and therapeutic aspects.
The article presents data on the prevalence of varicose veins of pelvic as the cause of chronic pelvic pain syndrome (CPPS) – differential diagnostic aspects of this common pathology. The data evaluation and treatment of patients with CPPS on the basis of venous congestion in the pelvic.
Key words: varicose pelvic veins, chronic pelvic pain syndrome, flebotonik’s drugs, troxerutin.
Heryak S. M., Shved M. I.
Metabolic syndrome and pregnancy: problems and solutions.
The modern criterias of metabolic syndrome are presents, including in pregnancy, methods of diagnosis in the early stages of development, that allow time to identify pregnant women with metabolic syndrome in a special category. The main objective of the treatment of metabolic syndrome in pregnant women is the need for recording and correcting the entire spectrum of available metabolic disorders and prevention of obstetric and perinatal complications. One promising way in the treatment and prevention of complications of pregnancy and childbirth in metabolic syndrome is a correction of metabolic disorders with LEKRAN 500©, which has a wide range of pharmacological properties with no side effects.
Key words: metabolic syndrome, pregnancy, diagnostic criterias and treatment.
Homyak N. V., Mamchur V. I., Khomiak E. V.
Clinico-pharmacological features of modern medicinal forms of micronized progesterone used during pregnancy.
The article describes the current concepts of the progesterone’s mechanisms of action as a protector of pregnancy. The features of the pharmacokinetics of progesterone using a variety medicinal forms of the drug. The advantages and disadvantages of different ways of administration (oral, intramuscular, vaginal and sublingual) are described. Presents an overview of a number of clinical studies on the efficacy of progesterone’s vaginal and sublingual administration in preparing for pregnancy, habitual miscarriage, and the threat of spontaneous abortion, including in vitro fertilization programs.
Key words: progesterone, Luteina, luteal phase deficiency, infertility, spontaneous abortion, preterm birth, in vitro fertilization.
Korchynska O. A., Gulpe K. Y., Voloshyna U. V.
Obstetric and Perinatal Aspects of Breech Presentation: a Well-known Facts and New Approaches to the Problem.
The article analyzes the approaches to solving problems in childbirth breech presentation. It is shown that such patients should be delivered by cesarean section to reduce perinatal morbidity and mortality.
Key words: breech presentation, obstetric and perinatal aspects.
Lybyana S. S., Liseenko E. V.
Investigation of reproductive health in pregnant with thyroid dysfunction.
The disorders of the thyroid status in 250 pregnant women in gestational age of 24–28 weeks was screened. A reproductive portrait of pregnant women with subclinical thyroid dysfunction was studied. The predominance of frequency of spontaneous abortions in subclinical hypothyroidism (27,7%) and non-developing pregnancy in the presence of antithyroid antibodies (17,9%) was revealed. Reproductive losses in 50% of women with subclinical hypothyroidism and antithyroid antibodies carriers were observed.
Key words: thyroid gland, thyroid antibodies, pregnancy, reproductive function, subclinical hypothyroidism.
Syusyuka V. G., Komarova O. V., Peycheva O. V., Averchenko E. G., Kaptyukh D. А.
Estimation of efficiency of special medical aid for women.
Carried out analysis of efficiency of obsteric aid permits to mention the positive work results of obstetrical clinic within 2009-2013. Decrease of quantity of abnormal labour and invariably low index of operative delivery occur and the cases of intranatal fetal death are absent. It is stated that one of the ways for decrease the quantity of abdominal labour and correspondently complicated labours is prophylaxis of the first scar which is possible only by means of thorough selection of indications for cesarean section. Important moments of prophylaxis of obstetric complications are the work with teenagers, students of schools, colleges, women of fertile age, couples to be married, which is directed at formation of priorities of healthy life-style, and organization and carrying out of preparation of pregnant women for delivery involving the family to the training in “School for preparing a family for delivery”.
Key words: pregnancy, obstetric complications, preterm delivery, cesarean section, manual examination of the uterine cavity, perinatal sickness rate and mortality.
Astakhov V. M., Batsylyeva O. V., Puz I. V.
Psychological accompaniment of pregnancy in the modern condition.
In the article pregnancy regarded as one of the most important stages of socialization women. Analyzed the problem of psychological support for women during pregnancy. Defines the main conditions for effective psychological work with pregnant women. Defines psychotechnologies and methods of work. Presents a program of psychological accompaniment for pregnant women, which is aimed to prevent all sorts of violations of maternal behavior. Article reveals the objectives of the program, substantiates theoretical and methodological principles. Presents a summary of lessons with pregnant women.
Key words: pregnancy, maternity, psychological accompaniment of pregnancy, psychotechnologies in work with pregnant.
Lutsenko N. S., Suliman Al H. M.
Objective criteria for assessing progress postpartum period.
Application of modern sonographic, immunological, biological, instrumental, laboratory and other methods of research to obstetrics has provided new data on the progress of physiological and complicated postpartum period as long ago as in the twentieth century. While little attention is paid to the hospital discharge criteria in physiological puerperium. Discharge from maternity hospital on the first day is common practice in the whole world. This phenomenon (application) is especially popular in the eastern countries, where women are discharged after 12–24 hours after uncomplicated labor and even cesarean. This procedure is applied in Syria, Turkey, Algeria and so on. Discharge of puerperants during the first day of postpartum period also finds its application in Turkey, Canada, USA. Meanwhile, Europe, Russia and Ukraine continue to adhere to the three-day discharge. For example, the recommendations of the Ministry of Ukraine (Order of the Ministry of Ukraine 29.12.2003 № 620, paragraph 2.16) provides for the discharge of mother and child on the forth;fifth day after birth in case of the normal course of postnatal period. Discharge on the third day after the physiological birth was approved by the Ministry of Health of Ukraine only in 2008, according to the order number 624. However, the available literature failed to find objective criteria for discharge from the hospital or documentary basis for such decision in any of the above;listed countries. One can only assume that early discharge in other countries is caused by the high cost of hospital stay, organized outpatient service after discharge, as well as the interest of insurance companies. The question of reasonable, safe early discharge from postpartum hospital is urgent for Ukraine by two reasons. First, it will help reduce the cost of the state, and secondly – to reduce the morbidity of newborns and mothers. This one is what countries, applying early discharge, are certain of.
Key words: postpartum period, uterine involution, physiological labor, ultrasound, birth injuries.
Dubossarskaya Z. M., Dubossarskaya Y. А., Radchenko V. V.
Modern pathogenetic concepts of psychoendocrine disorders with autoimmune thyroiditis.
In this literature review pathogenetic mechanisms psychoendocrine disorders with autoimmune thyroiditis and the relationship with psychological features of cytokines in the context of integration of the nervous, endocrine and immune systems as part of the general adaptation of the organism.
Key words: autoimmune thyroiditis, adaptation system, cytokines, psychology.
Makarenko M. V., Govseev D. A., Didukh T. E.
Application of hardware-software complex CAP ELM 01 «Andro-Gin» in obstetrics and gynecology. Personal experience.
Presented clinical results of treatment of 152 patients and observation showed that we use hardware-software complex CAP ELM 01 «Andro-Gin» is a clinically effective treatment of patients with complex obstetric and gynecological hospitals.
Key words: «Andro-Gin», physical factors, electrical, magnetic field, low-intensity laser radiation.
Reshetniak O. V., Lisjnaya T. O., Ponomareva I. G.
Microbiological researches oral cavity in women with fungous origin urogenital pathology.
It is set that in development of oral candida moniliasis at women with fungous origin urogenital pathology matters the combined role of features of microbiocenosis of different to the biotopes organism: oral cavity,vaginas,colon.
Key words: oral candida moniliasis,origin urogenital pathology,disbacteriosis.
Ioffe O., Iarotskyi M., Tarasiuk T., Stetsenko O., Tsiura Yu., Iarotska I.
Experience in performing single-port operations in gynecology.
Purpose – to determine the use and indications for use of single-port operations in gynecology.
Materials and methods. In the period from May 2010 to March 2014 38 laparoscopic single-port surgical operations for various gynecological pathology were performed. 35 operations was conducted for endometrial ovarian cysts, while in 12 patients performed simultaneous cholecystectomy about cholelithiasis, 5 patients – hernioplasty about an umbilical hernia. In 3 patients laparoscopic assisted transvaginal hysterectomy from transumbilical access were made.
Results and discussion. One-port operations were carried out using different ports: SILS (Covidien) – 5, TriPort™ Access System (Olympus) – 5, X-Cone (KarlStorz) – 27, Single Site Laparoscopic Access System (Ethicon) – 1. In 3 cases it was necessary posing additional trocar. Duration of operation with using single port access ranged from 40-50 minutes while removing ovaries, up to 250-300 minutes at hysterectomy. Postoperative complications from abdominal cavity and surgical wound were not found.
Conclusions. Using a single transumbilical access allows you to perform any required volume of surgery in gynecology, including simultaneous operations, reduce the intensity of postoperative pain, shorten the rehabilitation of the patient.
Key words: single-port surgery, transumbilical access laparoscopy.
Yaremchuk L. V.
Rating scale of cervical competence during pregnancy with the help of transvaginal echography.
As a result of examination of 964 pregnant women using transvaginal echography of uterine neck, we have established the range and average values of main diagnostics criteria of uterine neck. On the basis of received data we have developed and suggested to introduce in practice an echosonographic rating scale for the assessment of cervical competence during pregnancy both for healthy and pregnant women who are threatened with isthmic-cervical insufficiency. This scale includes 5 main criteria and rating is done for 0, 1 or 2 points. If total points make 8–10, uterine neck is considered to be competent, if it makes 5–7 points uterine neck is considered to be doubtful and if it’s 4 points or less then we have isthmic-cervical insufficiency. Timely diagnostics, correct assessment of ultrasound diagnostics of cervical incompetence during pregnancy and its rational treatment give an opportunity to lower the number of cases of premature births and reduce the percentage of premature losses.
Key words: transvaginal echography, rating scale of cervical competence, isthmic-cervical insufficiency.
Rudenko I. V., Mishchenko V. P., Zaporozhchenko M. B., Kolesnikova V. V., Andreev S. V.
Predconceptional preventive maintenance of reproductive losses of the multifactor nature.
327 women on presence of risk of development obstetric and perinatal complications by definition of genotypes of a receptor of a progesterone (PGR PROGINS), vascular-endotelial a growth factor (VEGF 1154 G/A), endotelial cyntase oxide of nitrogen (eNOS3), methylentetrahydrofolatreductase (MTHFR 677 С/Т) are surveyed. Degree of risk of congenital predisposition of development obstetric and perinatal complications made in points. At a relative score in the middle of a gene grid it is more 1,1 the risk of congenital predisposition to development obstetric and perinatal complications is raised, in a range from 0,9 to 1,1 – the risk is not expressed, less than 0,9 – risk minimum. The size of an interrelation of chances (odds ratio, ОR) at joint polymorphism has compounded 1,5 and was in confidence interval limens (CI) 0,53-2,19; P=0,95. Identification of functional genetical models which is associated with multifactor illnesses, obstetric and perinatal complications allow to position hereditary predisposition to certain diseases, can have prognosticе value at a stage of planning of pregnancy and allow to plan preventive measures.
Key words: рredconceptional preventive maintenance, reproductive losses, gene grids.
Lyalina E. A., Lapochkina N. P., Kozina M. V.
Prevention of infectious and inflammatory complications after organ-sparing surgery for ectopic pregnancy.
The authors studied the efficacy of polygynax used in complex preventive therapy for infectious complications after organ-sparing surgery for ectopic pregnancy. Eighty-two women who had undergone emergency organ-sparing surgery for ectopic (tubal) pregnancy were examined. The results of the investigation are suggestive of the potentiated effect of prevention of infectious and inflammatory complications during emergency surgical interventions if local antibacterial therapy was used. Thus, an inadequate prophylactic effect of antibacterial therapy was observed only in 13.5% in the women using local anti-inflammatory therapy (polygynax) and in 43.3% among those without receiving the latter (p<0.05).
Key words: ectopic pregnancy, organ-sparing surgery, prevention of infectious and inflammatory complications, polygynax.
Krut J. Y., Puchkov V. A., Lubomirskaya K. S.
Incomplete pregnancy and premature rupture of membranes.
In this article the results of the literature review on the subject of premature rupture of membranes in incomplete pregnancy and present-day opinion on this problem is given. The morphological changes of placenta for pregnant with premature rupture of membranes at preterm labor and rational management of pregnancy prolongation is given.
Key words: premature rupture of membranes, termination of pregnancy, incomplete pregnancy, premature birth.
Melikova U. F., Aliyeva E. M., Asadova S. S., Kerimova S. N., Shadlinskaya S. V.
The specifical features of pregnancy, delivery, fetal status and the neonate in a pregnant women with eclampsia.
The air of investigation was the study of specifical features of pregnancy, fetal status and the neonate in women with eclampsia according to the retrospective data 12 delivery histories of the patients with eclampsia were analyted. It was determined that the average number of seazures in patients with eclampsia was 2,0±0,28. Eclamptic seazures occurred in 20,73±1,4 weeks. The guantity of preterm vaginal deliveries was 44,4%, whill cesarean deliveries occurred in 55,5%. The nimber of term vaginal deliveries occurred in 33,3%, white addominal cesarean delivery in 66,6%. One patient had cerebral haemorrage and another one had acute renal insufficiency. The index of antenatal death was egual to 166,6‰, intranatal death – 166,7‰ and postnatal death – 250‰. Perinatal death was seen in 583,4‰.
Key words: eclampsia, perinatal death, preterm delivery, term delivery, early neonatal death.
Sadovoj A. P.
Features of a current of pregnancy depending on type of anomaly of development of uterus.
Results of the spent researches testify that patients with different forms of anomalies of uterus make group of high risk on development of the basic complications of pregnancy. The most general clinical moments for all patients with anomalies of a uterus are high frequency of initial barreness, incompetence of pregnancy, including habitual, a background for which not only anomalies as those, but also accompanying gynecologic diseases. The received results dictate necessity further studying the given problem, especially in aspect of improvement perinatal outcomes of delivery.
Key words: anomalies of development of uterus, pregnancy complication.
Butkova O. I., Zhabchenko I. A., Didenko L. V., Kovalenko T. N.
The results of retrospective analysis of the course of gestation and deliveries under postmaturity of pregnancy.
According to data of retrospective clinical;statics analysis of 130 recordings of deliveries of women with postmaturity of pregnancy (on the basis of clinical archive of GI «IPOG of NAMS of Ukraine» for 2008–2012). Frequency of postmaturity of pregnancy was 10.8%. The most significant risk factors of postmaturity of pregnancy were defined: burdened obstetric anamnesis (65.0%); complicated course of the current pregnancy (95.6%); extragenital diseases (66.1%).
Key words: pregnancy, postmaturity, risk factors.
Fetoplacental hormone concentrations in the serum of patients infected with influenza virus A/H1N-California.
The concentration of hormones of fetoplatsental complex and their dynamics after the trimesters of gestatsii is probed in the serum of blood 306 patients, infected by the virus of flu of A/H1N1 Californium. Considerable violations of hormonal status of steroid hormones are exposed at pregnant, infected by the virus of flu of A/H1N1 of Californium. Violation of processes of synthesis of steroid hormones (insufficiency of products of progesteron) takes a place in investigation of defeat the infectious agent of receptors of endometrium with the change of his secretory properties, has reliable connection with unmaturing of pregnancy, wilful abortions, stopping beating pregnancy and grounds to assert about development of placental disfunction at pregnant. Further researches the flows of gestation processes directed on the study of features at this category of pregnant.
Key words: hormones of fetoplacental complex, a virus of flu of A/H1N1 California, pregnancy.
Vakaluk L. M.
The reproductive history of women delivered of caesarean section.
On the base of hospital-statistical analysis of cesarean sections cases, was studied reproductive function of 250 women. These patients form group of high perinatal risk, and must be carefully observed on hospital stage of obstetrical-gynecologic service, and they form reserve for demographic situation. Special offices for mothers (families) need to be formed for deciding reproductive health problems after cesarean section.
Key words: cesarean section, reproductive function.
Venckivskiy K. O., Zagorodnya O. S.
Immunological changes in HIV-positive pregnant with associated herpes-infection.
An analysis of the clinical course of the first half of pregnancyin HIV-infected patients and women with HIV-associated HSV infection is considered in the article. It is shown that along with inhertent to the HIV-infected pregnant high incidence of infectious gestational complications studied group also had a significant risk of miscarriage. Features interleukins’balance dy studied pregnant women and their importance in the development of gestational complications are discussed.
Key words: HIV infection, herpes infection, gestational complications, interleukins.
Tymoshkov M. V., Rybka O. V.
Features pathogenic biorehulyatsiynoyi therapy for inflammatory diseases of the pelvic organs.
The use of complex drug Ginekoheel by biorehulyatsiynoyi action allows to add and enhance pathogenic anti;inflammatory therapy both acute and chronic inflammation of the female genital tract, thereby increasing the effectiveness and safety of treatment of inflammatory diseases of the pelvic organs.
Key words: Ginekoheel, PID.
Вуттке В., Ярри Г., Зайдлова-Вуттке Д., Уварова Е. В., Девятченко Т. Ф., Гуменюк Е. Г., Погодин O. K., Левенец C. A.
Терапевтические возможности экстрактов из Авраамова дерева (Vitex Agnus castus) в гинекологической практике.
Andreeva E. N., Grigoryan O. R., Sheremetyeva E. V.
The influence of folate-containing combined oral contraceptives on homocysteine level in women with polycystic ovary syndrome.
Objective. To investigate the influence of Yarina Plus (ethynylestradiol/drospirenone/ calcium levofemolate) on homocysteine level in women with polycystic ovary syndrome (PCOS).
Methods. Single-center, open labeled prospective parallel-group randomized controlled trial. 75 females (aged 26.7±1.8 years old) with PCOS diagnosed on the base of ESHRE/ASRM consensus (2003) were divided into 3 groups (n=25 each). Group 1 received EE/Drospirenone/calcium levomefolate, group 2 used non-folate combined oral contraception without folates (Yarina) and group 3 received no treatment.
Results. Basal homocysteine levels in groups 1, 2 and 3 were 13.1±4.2 jmol/l, 12.9±5,0 jmol/l, 10.2±3.9 jmol/l, respectively. After 6 months of the therapy the homocysteine concentration decreased significantly in group 1 (8.7±2.5 jmol/l, (p<0,01); in groups 2 and 3 there was no significant changes (p>0,05).
Conclusion. Folate-containing combined oral contraception is effective way of providing optimal folate level in patients with PCOS before planning pregnancy.
Key words: polycystic ovary syndrome, homocysteine, drospirenone, folates.
Yashina E. G., Lasachko S. A.
Clinico-pathogenetic substantiation of correction failure luteal phase of the menstrual cycle in women with breast diseases dyshormonal.
The article presents data on the prevalence of combined forms dishormonal disorders in women of reproductive age, the characteristics of menstrual and reproductive function in women with breast diseases dyshormonal. Also studied the effectiveness of cyclic use of the drug in combination with Tazalok progesteronoterapii application and as a self-correction method in women with luteal phase deficiency menstrual cycle and DBD.
Key words: dishormonal breast disease, lack of luteal progesterone Tazalok.
Lasachko S. A.
Regression analysis of major risk factors for non-tumor breast diseases in women of reproductive age.
The article presents the results of the regression analysis of the major risk factors such dishormonal breast diseases, as dysplasia, galactorrhea, mastalgia in women of reproductive age. Performed univariate analysis using the simple linear regression data from medical documents of outpatients in 1057 women from the main group and 190 apparently healthy women (control group). 62 factors analyzed, 14 of which in relation to reproductive history, 8 – character formation and menstrual function, 7 – related gynecological diseases, 20 – lactation history, 5 – endocrine diseases, 3 – about unhealthy habits. A history of preterm missed pregnancy, lactation disorders, smoking and thyroid gland diseases have the greatest negative impact influence, whereas long-term lactation and later age at menarche showed a protective effect.
Key words: breast, reproductive health, dishormonal disorders, regression analysis, risk factors.
Pavlushenko S. D.
Role of the cytolytic vaginosis to relapse of benign cervical pathology.
The aim of this study was to investigate the role of disturbances in the vaginal biotope recurrences of benign cervical disease. The study involved 162 women of reproductive age who during the annual examination diagnosed a recurrence of benign cervical pathology. Extras were examined 40 women who had a history of benign pathology of the cervix, but not control examinations had recurrences and 30 conditional somatic and gynecological healthy women. In 76.54% of the women expressed a core group registered dysbiosis, and at 9.88% – cytolytic vaginosis. These data indicate that cytolytic vaaginoz is one of the risk factors for recurrence of benign pathology of the cervix, which is not necessary to consider in developing an integrated approach to their treatment and prevention of recurrent relapse.
Key words: recurrence, benign cervical disease, cytolytic vaginosis microbiocenosis, pH-metry.
Gerasimov T. V., Gopchuk E. N.
Correction of dysbiosis of genital tract in women of reproductive age on the background dishormonal violations.
The results of a study on the effectiveness of adjuvant therapy dishormonal disorders and dysbiotic disorders of vaginal microflora with the influence on the etiology and pathogenetic mechanisms of development of the pathological process are presented in the article.
Key words: dishormonal disorders, menstrual disturbances, dysbiosis, Bioselak, Gold Ray.
Nastradina N. N.
Gynecological examinations of women with reccurent background cervical deseases.
Subject of this study was caused by the difficulty of diagnosis of precancerous and cancer. Therefore, this article presentation of the results of gynecological examination of women with recurrent cervical disease background and analyzed the features of the state of the cervix. Boule collection and analyzes data regarding health, gynecological complaints, duration of background diseases and visual study pulpatornoho cervix kalkoskopichnoho study.
Key words: gynecological examination, kalkoskopiya, cervix, palpation, cytology.
Golyanovsky O. Vl., Roshchina G. F.
Effectiveness of pharmacotherapeutic action of indole-3 – carbinol in a preparation Kvinol.
Estrogen-dependent proliferation in the female reproductive system leads to the development of proliferative diseases – endometrial hyperplasia, endometriosis, uterine fibroids, fibrocystic disease of the breast (mastitis). Some of estradiol metabolites are actively involved in the progression of initiation of these processes. Phytonutrients indole-3-carbinol, which is part of the drug Kvinol normalizes hormonal balance and leads to the regression of clinical symptoms and structural formations with proliferative diseases of the reproductive system of women.
Key words: estrogen- dependent proliferation of endometrial hyperplasia, endometriosis, uterine fibroids, fibrocystic breast disease (mastopathy), phytonutrients, indole-3-carbinol, Kvinol.
Banyra O. B., Nikitin O. D.
Aspects of Tribulus Terrestris extract use in the treatment of infertility and sexual disorders.
Based on the results of numerous clinical trials it has been summarized that extract of Tribulus Terrestris demonstrates proven effectiveness in the treatment of female endocrine infertility, chronic nonspecific inflammatory diseases of the pelvic organs and menopausal disorders in women, immunological infertility and sexual adjustment disorders. There were presented the schemes proposed by the clinicians. All the researchers noted the efficiency of Tribulus Terrestris extract and the absence of significant side-effects. It looks that could be reasonable the future research of this plant extract ability to remove ovarian cysts and resume ovarian activity in women with diminished ovarian reserve.
Key words: Тribestan®, infertility.
Features of using of contracetptives among fertile aged women that had medical abortion.
Data of survey of fertile aged women, that had medical abortion operation, are showed in the article. Questionnaire was specially designed for this study. Results shows, that 36,7% of women afraid of hormonal contraception, 83,3% are using condoms, and 16,7% are using IUD’s.
Key words: methods of contraception, survey, reproductive health, medical abortion.
Pitko V. А., Loginova О. А., Тkachev А. I., Коlesnikova А. А., Pokoziy E. S.
The comparative characteristic of efficiency of fertilization in vitro protocols dependent on pharmacological components of conducting controlled stimulation of ovaries.
The investigation of efficiency of protocols of controlled stimulation of ovaries in programs of fertilization in vitro with using of different drugs combination which potentiate of folliculogenesis was carried out. It was found that in programs of artificial reproductive technologies with patients younger than 35 years old more effectiveness was protocols with using of recombinant follicle;stimulating hormones but in patients of 35 years old and older more resultant was protocols with application of urinary drugs, and on finish stages of performance of folliculogenesis stimulation rational was using of combine urinary drugs.
Key words: programs of fertilization in vitro, controlled stimulation of ovaries, artificial reproductive technologies, recombinants follicle-stimulating hormones, urinary follicle-stimulating hormones.
Mykytenko D. O., Lavrova K. V., Masliy Yu. V., Zukin V. D.
Prognostication of obtaining of euploid embryos in ART cycles u sing PGS.
It was shown the age-related decreasing of main quantity of obtained embryos in ART cycles, frequency of blastulation and increasing of quantity of aneuploidies on account of multiple chromosomal anomalies. It were calculated the proportion of euploid embryos are available for transfer according to mentioned parameters, probability of ART cycle closure by transferring at least one euploid embryo according to maternal age. Recommendations are proposed in relation of preimplantation genetic investigation and including of advanced age patients to the embryo banking programs.
Key words: ART, preimplantation genetic screening, aneuploidy, prognostication.
Hourani I. F., Kakar’kin A. Ya., Odarchenko P. Ya., Matsishevskaya I. V., Schnaiderman P. Yu., Shevnya S. P., Tkachuk T. V.
Application of filgrastim during breast cancer neoadjuvant chemotherapy.
The work is devoted to the assessment of thecolony stimulating Filgrastim factor protectoral impact during the neoadjuvant chemotherapy by the CAF and TAC schemes. It was shown that the prophylactic prescription of Filgrastim in a dose of 5 mcg/kg per day for 5–7 days leads to a significant reduction in hematologic and gastrointestinal toxicity of NAHT, preventing the development offebrile neutropenia and reducing the stage III neutropenia in almost 1.7 times, thrombocytopoenia – in twice, anemia – in 2,9 times. Filgrastim application significantly reduces the percentage of stomatitis and has antiemetic effect. Filgrastim showed a more pronounced therapeutic effect at patients, treated by the chemotherapy scheme CAF.
Key words: breast cancer, neoadjuvant polychemotherapy, Filgrastim.
Фитоэстрогены – подарок природы для женщин.