HEALTH OF WOMAN WH_№3_2014
Gopchuk E. N.
Tribestan in the complex therapy of inflammatory diseases of the pelvic organs in women.
An information about the complex of effects of of Tribestan, perspective and possibility of his wideuse in gynaecology, including for therapy of inflammatory diseases is presented in the article.
Key words: Tribestan, Tribulus terrestris L, inflammatory diseases of small pelvic organs, treatment.
Львівський Медичний форум!
Шурпяк С. А.
Роль прогестагенов в предупреждении гестационной гипертензии.
Национальная стратегия профилактики рака репродуктивных органов: Всеукраинская телеконференція.
Всемирному дню борьбы с раком, который во всем мире отмечают 4 февраля, посвятили Всеукраинскую телеконференцию «Национальная стратегия профилактики рака репродуктивных органов: проблемы и перспективы». Телеконференция состоялась 29 января 2014 года и транслировалась на сайтах medprosvita.com.ua и oncodozor.com.ua. Организовали и провели встречу ведущих специалистов общественное объединение «Украинская федерация борьбы против рака» и медицинско-просветительский проект «Онкодозор» при активном содействии и участии главных специалистов Министерства здравоохранения Украины по специальностям онкология, акушерство и гинекология, онкогинекология, урология. В рамках телеконференции обсуждались вопросы диагностики, лечения и профилактики онкологических заболеваний репродуктивных органов. Участники получили возможность в задать ведущим отечественным специалистам вопросы и обсудить проблемы диагностики, профилактики и лечения рака репродуктивных органов в Украине.
Бактериальный вагиноз: от новых трендов науки к практическим решениям.
В XX веке с трибун микробиологических конференций стали планомерно популяризировать новую идею – опустевшую нишу обитания микрофлоры после исчезновения последней незамедлительно заселяют другие микроорганизмы. Эта концепция вскоре отразилась на клинической практике акушеров-гинекологов: стремление к стерильности влагалища как к идеалу (доктрина советской гинекологии 1960–70-х годов) ушло в прошлое, освободив место современным представлениям о невозможности существования репродуктивной системы без бактерий. И эта новая для нас область – вагинальная микроэкология – каждый год преподносит нам сюрпризы, обновляя систему знаний и предлагая все более эффективные клинические решения.
Benyuk V. A., Maidannyk I. V.
Achievements and prospects of development obstetric and gynecological science in Ukraine.
The article presents the achievements and prospects of development of obstetric science in Ukraine. Described aspects of the Department of Obstetrics and Gynecology, Kiev, Lviv, Kharkiv, Donetsk, Odessa, Poltava, etc. These areas of work at different stages of development, science, discoveries and achievements.
Key words: history, science, obstetrics and gynecology, Ukraine.
Slabkiy G. O., Kachur O. Yu.
Availability women modern methods of radiation diagnosis (based on a poll).
The results of a poll of female patients tier healthcare care on the availability of modern methods of beam diagnostics. The study is set too low, both physical and financial access to modern methods of beam diagnostics.
Key words: modern radiological techniques, health second level, women, accessibility.
Semenova E., Kunina M., Stuklov N.
Role оf Copper And Manganese In Iron Metabolism.
Twenty-two manganese proteins and 9 cuproenzymes are involved in human iron metabolism. Iron monotherapy fails to take into account trace element interactions and may be therefore accompanied by the higher rates of side effects, and, in case of copper deficiency, may cause the body’s iron overload or treatment refractoriness. The use of a combination of iron, copper, and manganese allows such results to be avoided.
Key words: anemia treatment, ferrous gluconate, ferrous sulfate, iron deficiency, copper deficiency, copper gluconate, manganese gluconate, Totema, Sorbifer durules.
Romaniuk M. G., Vdovychenko Yu. P.
What choice is right: GnRH agonist versus GnRH antagonist in ovarian Stimulation before IVF/ICSI? (Literature review).
Use of gonadotropin-releasing hormone(GnRH) blockers for ovarian stimulation caused the appearance of a large number of meta-analyses that compared blockers GnRH protocols use with GnRH agonists. These meta-analyses have shown conflicting results regarding pregnancy rates, with a trend in favor of the best indicators in GnRH agonists. Recently Cochrane review resolved these contradictions and demonstrated the lack of statistically significant differences in terms of live births or ongoing pregnancies, when compared protocols that include GnRH agonists or blockers. In this article the equivalence of these two protocols, which has been described in recent meta-analysis, is questioned. The arguments that the GnRH agonists have a significant advantage over blockers are presented.
Key words: GnRH agonist, GnRH antagonist, IVF outcome, pregnancy.
Kulchavenya E. V., Brizhatyuk E. V., Khomyakov V. T., Breusov A. A.
Features of the incidence of cystitis depending on the type of contraception.
For the purpose of evaluation the effect of contraceptive methods on the incidence of recurrent bacterial cystitis in women, 215 clinical records of patients with cystitis were analyzed. In addition, incidence of recurrent cystitis in three groups of sexually active women of reproductive age was compared: 26 patients (Group 1) received conventional therapy and used condom as a method of contraception; 31 patients (Group 2) received combined oral contraceptives (COC), and 32 patients (Group 3) received COC and two courses of treatment with canephrone. A negative correlation between COC use and the risk of cystitis was detected. After conventional therapy, recurrences were observed in 43.3% of patients in Group 1, in 25.8% of patients in Group 2, and only in 15.6% of women in Group 3. Thus, the choice of COCs for contraception lead to 2- fold reduction of risk of recurrence of bacterial cystitis, and additional use of canephrone – to 3-fold reduction.
Key words: cystitis, relapse, contraception, prevention.
Chayka V., Nosenko E., Orazov M.
The complex treatment of of chronic pelvic pain for women with adenomyosis.
An algoritm for the complex treatment of chronic pelvic pain in women with adenomyosis pathogenetically and clinically substantiated efficacy of GnRH-agonist in combination with intrauterine system Mirena-levonorgestrelcontained prevents recurrence of pelvic pain in women with adenomyosis. The proposed therapeutic approaches aimed at increasing opportunities for prevention of recurrence of pelvic pain in patients with adenomyosis.
Key words: chronic pelvic pain, adenomyosis, adhesive process, dysmenorrhea, diferelin, intrauterine system Mirena levonorgestrelcontained.
Ligirda N. F.
Colposcopy in pregnancy especially rules.
The study involved 84 pregnant patients with normal cytology who have no history of any medical interventions on the cervix. Of these, 40 – primiparous (I group) and 44 – multiparous (II group). Studied and defined features colposcopic pattern norms in pregnancy in I and II trimesters. The features of the colposcopic studies in pregnant women at different stages. Found that the structure colposcopic manifestations of physiological adjustment in normal mucosa during pregnancy has no significant differences in primiparous and multiparous women, in both the first and second trimesters. Both groups found that significantly more frequent manifestations of physiological adjustment mucosa, occur in the second trimester of pregnancy. Except metaplasia processes that are activated in the first trimester and are replaced by irregular thickening of the epithelium – in the second trimester.
Key words: colposcopy, pregnancy, metaplasia norm.
Makarenko M. V., Govseev D. A., Michalcsuk P. F., Tyan O. V.
Optimization assisted laparoscopic hysterectomy in patients with prolapse of the uterus.
We note the feasibility of laparoscopic Assisted transvaginal hysterectomy group of patients requiring removal of the uterus with adhesions pelvic intraligamentarnaya located uterine fibroids, and the absence of septic complications, a good cosmetic effect, minimal intraoperative blood loss, shortening hospital stay, reduction of consumption of antibiotics to confirm this.
Key words: prolapse of the uterus, adhesions, laparoscopy, extragenital pathology.
Donskaya Y. V., Potapov V. A., Medvedev M. V.
Treatment strategy of combined hormone disorders in women of reproductive age.
The article covers issues of organ-sparing therapy of mentioned hormone-dependent uterine pathology at the preoperative stage, during surgery and after surgery. Combined use of preoperative polymaltose complex hydroxide iron (III) complex with intraoperative measures, including local modern hemostatics and post;operative therapeutic course with combination of GnRH agonists and COCs significantly improved the results of surgical treatment to reduce the incidence of complications, improve the rate of pregnancy, and also significantly reduce the frequency of relapses both endometrial hyperplasia and uterine leiomyoma.
Key words: uterine leiomyoma, endometrial hyperplasia, organ-sparing therapy.
Chaika V. K., Govorukha I. T.
Diagnostic and therapeutic possibilities concerning the prevention of preterm birth in women with infertility cured.
Actions on maintaining pregnancy in women with healed infertility, including diagnostic marker and treatment of preterm labor with the use of the test drug and Actim Partus atosiban ( traktotsila ). This approach can reduce the incidence of preterm birth, low birth-weight children and perinatal losses .
Key words: premature birth, infertility, diagnosis, treatment.
Veropotvelyan N. P.
The meaning of alloimmune mechanisms in the event of early reproductive loss in couples with recurrent miscarriage.
The present work represents the results on determination of alloimmune factors role in the genesis of recurrent miscarriage in couples of the south-eastern and central regions of Ukraine conditioned by the main complex of hystocompetibility of the second class. According to the received data more than 20% of couples with recurrent reproductive miscarriages have a high number of coincidence according to the system HLA of the second class (from 3 to 5). In 30 % of the cases there is carrying of inclination allelles to unembryonia (DQA1 0201 or DQB1 0201). There is a suposition that carrying of «unembryonia allelles» in case of 2 coincidence is considered to be such a significant factor of inclination to pregnancy miscarriage as a bigger number of coincidence.
Key words: pregnancy miscarriage, hystocompetibility, unembryonia.
Lukyanovа I. S., Yanyuta G. S., Sopko Y. A., Yanyuta A. S.
On the specifics of uteroplacental and fetal circulation of pregnant patients with cardiomyopathy (based on Doppler assessment).
During the pregnancy the main condition of cardiomyopathy patients deteriorates, which leads to heart failure, heart rhythm disorders, thromboembolism and causes various complications during pregnancy and delivery, and jeopardizes the fetus and the baby. The findings suggest that Doppler studies of uteroplacental and fetal circulation in this group of pregnant women are highly effective for predicting perinatal complications.
Key words: pregnancy, cardiomyopathy, uteroplacental and fetal circulation, Doppler.
Veropotvelyan P. N., Bila V. W., Veropotvelyan N. P., Narytnik T. T., Guzhevskaya I. V.
Current clinical approach in treatment of preterm labour.
We present the results of our research of the risks of complications in patients with preterm labours. Studied in numerous publications and our research data of treatment of preterm labor allow to achieve the positive results in reducing neonatal morbidity and mortality.
Key words: preterm labour, β2-agonists, tocolysis, oxytocin receptor blockers and calcium channel, progesterone, magnesium sulfate, calcium antagonists.
Volosovsky P. R.
Placental dysfunction at women with extra-uterine pregnancy in the anamnesis.
Results of the spent scientific researches testify, that pregnancy and childbirth at the women who have transferred extra-uterine pregnancy is enough an actual scientific problem. Thus at pregnant women of this group, especially after auxiliary reproductive technologies develops placentary dysfunction mixted genesise (microcirculation infringements, endocrinological insufficiency and high level microbic), the basic ehografical which displays begin from 18–20 weeks and progressively accrue up to delivery. High level obstetrical and perinatal pathologies caused, first of all, infringements in system mother–placenta–fruit that is the reason of high frequency abdominal delivery.
Key words: placental dysfuction, extra-uterine pregnancy.
Kovalyuk T. V., Benyuk V. О.
Psycho-emotional and neurovegetative adaptation features of pregnant with nutritional deficiency of body weight.
This article presents the results of the psycho-emotional and neurovegetative adaptation study of pregnant women with body weight nutritional deficiency. Established that women with body weight nutritional deficiency in was significantly higher levels of personal and reactive anxiety on a scale of Spielberger – Hanin, stress index based on the results of computer cardiointervalography and lower total power spectrum of heart rate variability, which indicates a decrease in the stock of adaptive – compensatory reactions that can mobilize the body to respond to stress load.
Key words: pregnancy, nutritional deficiency of body weight, emotional adaptation, pregnant neurovegetative adaptation.
Vakalyuk L. M.
The scar on the uterus after cesarean section on the clinical and morphofunctional analysis.
In clinical material consists of complex clinical and morphological analysis of the uterine scar after cesarean section. These results reflect the morphogenesis of wound healing histerotomy to form morphofunctional and clinically isolated rumen of three types: full, relatively complete and defective. Results of the study will contribute to the development of complex general clinical and surgical measures to improve histeroraphy generally will improve the health and future of women’s reproductive delivery of caesarean section.
Key words: caesarean section, scar of uterus, morphology.
Golyanovsky O. V., Ramazanov V. V., Pekhnyo T. V., Salnikov S. N., Gerbut V. V.
Nutritional support in the complex therapy of preeclampsia.
The efficiency of nutritional mixture « Frezubin VP Energy» as an additional component of complex therapy of the preeclampsia in 37 pregnant women with preeclampsia mild to moderate severity. Found that nutritional support can improve the effectiveness therapy of preeclampsia and stabilize pregnant promotes and prolongation of pregnancy, reduce the frequency and severity of respiratory disorders in the newborns.
Key words: рregnancy, preeclampsia, metabolic stress, protein energystarvation, nutritional support.
Veropotvelyan P. N., Veropotvelyan N. P., Zhabitska L. A., Guzhevskaya I. V.
A clinical view at the treatment of recurrent miscarriage in anamnesis using the method Photodynamic therapy in patients with chronic mixed-viral infections.
This article is devoted to the study of the results of research on photodynamic therapy (PDT). On the basis of foreign literature and the modern views of the laser radiation. Shows the results of the latest scientific developments in preclinical studies and the application of PDT as its antibacterial and antiviral therapy. Analyzed a number of experimental studies on the role of PDT as a primary herpes infection, the dominant causal factor of recurrent miscarriage. Given the urgency of the problem of miscarriage associated with herpes virus infection, it is necessary to continue to study the action of PDT and capabilities of its antibacterial and antiviral effects.
Key words: recurrent miscarriage, photodynamic therapy, chronic mixed-viral infection.
Doroshenko I. V.
Features of anaemia pregnant at women with a chronic pathology of liver and gastroenteric path.
Results of the spent researches testify to an essential role initial liver pathologies in frequency of development and clinical current of an anaemia of pregnant women. It proves to be true higher frequency of
various complications at delivery: premature rupture fetus covers (+16,7%); distress of born (+11,2%); anomalies patrimonial activity (+8,4%) and bleedings in placental and early postnatal the periods (+5,0%). The analysis of a condition of newborns has shown has shown higher frequency asphyxia to average (+6,7%) and heavy degree (+2,9%), and also patrimonial trauma (+2,9%) in a subgroup of patients with combination of pathology of a liver and a gastroenteric path to an anaemia of pregnant women. Similar law was observed and at a clinical estimation early neonatal period: posthypoxial encephalopathy (+20,8%); hyperbilirubineamia (+9,8%); postnatal infection (+8,1%) and hemorragical syndrome (+2,8%). The received results testify to necessity of improvement of algorithm of diagnostic and treatment-and-prophylactic actions for improvement of results delivery at patients with the given somatic pathology.
Key words: anaemia of pregnant women, pathology of liver and gastroenteric path.
Veropotvelyan P. N., Narytnik T. T., Veropotvelyan N. P., Smorodskaya E. P., Guzhevskaya I. V.
Clinical view of the methods used to interrupt pregnancies of 12-22 weeks.
In article presented the modern principles of peculiarities of abortion in term 12–22 weeks. It was analyzed and learned a lot of publication about evidentiary results of using especially technology, privileges, risks and efficiency of different methods of abortion on base of dates of royal College RCOG of Great Britain, results of American College of Obstetricians and Gynecologist ( ACOG, USA) 2011–2012 years. In our country we have to follow the order Ukrainian Ministry of Health №423 from 24.05.2013 for abortion on later terms.
Key words: pregnancy, methods of abortion in later terms on 12–22 weeks, medicament abortion, surgical abortion.
Пашинян А. Г., Саламова И. В., Хейдар С. А., Семенова В. Б., Арутюнян Г. Б.
Современные местные поликомпонентные препараты в лечении вульвовагинитов смешанной этиологии
В статье освещены современные представления об этиологии неспецифических инфекционных заболеваний влагалища. В последние годы все больше регистрируются микст-инфекции, характеризующиеся более тяжелым и длительным течением, частым рецидивированием процесса, развитием восходящей инфекции. Представлены данные, подтверждающие клиническую эффективность поликомпонентных интравагинальных капсул, имеющих в своем составе неомицин + ністатин + полимиксин B, при лечении вульвовагинитов смешанной этиологии.
Ключевые слова: вульвовагиниты смешанной этиологии, поликомпонентные лекарственные препараты.
Vdovichenko J. P., Gavrjushov D. N.
Clinical value anamnestical features at hyperplastic processes of endometrium.
Results of the spent researches testify that at patients with instructions in the anamnesis on high frequency intrauterine manipulations and presence chronic endometrite relative risk of development hyperplasia of endometrium in 11 and 10 times above, than in population that testifies to presence of the expressed relationship of cause and effect between the given pathological processes and disease development of endometrium. Any long infringement menstrual functions (> 2лет) raises risk of development of hyperplastic processes of endometrium in 6 times, and in the presence of hyperplastic processes of endometrium in the anamnesis the risk of relapse increases in 2 times. The combination of hyperplastic processes of endometrium and chronic endometrite takes place in 22,9% of cases, and in 15,2% of supervision is diagnosed chronic endometrite with jet гиперплазией. At patients with a combination of hyperplasia endometrium and chronic endometrite and with jet hyperplasia, in comparison with hyperplasia without atypia and with atypia, earlier beginning and expressiveness of clinical symptoms of the disease which duration exceeds 2 years. At women with simple and difficult typical and atypical hyperplasia communication between a morphological variant of pathological process is marked and patognomical clinical semiology is absent. In structure of accompanying diseases at patients with presence chronic endometrite prevail (in comparison with hyperplasia without atypia and with atypia) inflammatory processes of bodies of a small basin, good-quality diseases of cervix uterus, hyperplastic processes of endometrium that testifies to the expressed system character of a pathology. The received results are necessary for considering by working out of algorithm of diagnostic and treatment-and-prophylactic actions.
Key words: hyperplastic processes of endometrium, clinic, the anamnesis.
Shadrina V. S.
The role of immunomodulators in the treatment of cervical pathology.
The results of study of the efficacy and safety of recombinant interferon-alfa-2b in treatment of cervical pathology is presented in the article. The reseach shows high clinical effectiveness of the proposed regimen of cervix pathology with the use of Laferobion rectal suppositories.
Key words: pathology of the cervix, kmmut papilloma rims Laferubion, treatment.
Kornatska A. G., Chubei G. V., Brazhuk M. V., Kondratyuk V. K.
Rehabilitation of women’s reproductive function after organ preserving surgery for pelvic organs.
Analysis of results of 353 organ preserving surgery on the pelvic organs was conducted. Optimizing choice of surgical approach, active postoperative care, and use of proteolytic enzymes (Serrata®) in the early postoperative period contributed to the absence of complications in the postoperative period, along with decrease in the intensity of pain and its duration. Long-term results showed decrease in the frequency of adhesions. Indication of serratiopeptidase helped to restore reproductive function in 58,1% of patients.
Key words: organ preserving surgery, pelvic organs, adhesions, serratiopeptidase.
Vdovichenko J. P., Turlinova Z. A.
Tactics of auxiliary reproductive technologies at patients with hyperandrogenia of various genesise.
Results of the spent researches testify to efficiency of offered algorithm of the differentiated approach to carrying out of auxiliary reproductive technologies at women with hyperandrogenia with the account not only genesise, but also presence of accompanying adiposity, a metabolic syndrome and a syndrome polycystes ovariums. The presented data allows to recommend advanced algorithm for wide use in offices and clinics reproductology.
Key words: hyperandrogenia, auxiliary reproductive technologies.
Pyrohova V., Veresnyuk N., Golyuk N.
Modern trends in diagnostic and treatment tactics in the background cervical diseases.
Application of the combined preparations of local action, which influence on the wide spectrum of possible pathogenic microorganisms and not instrumental in the origin of system allergic reactions and inversion of immune defence of organism, acquires at presence of pathology of cervices, vagina combined with inflammatory processes, special value. It is inspected and treated with Neotrizol 100 patients with the signs of cervicitis. Before treatment for swingeing majority of patients was characteristic polimicrobial surplus contamination of vagina and cervices gram-positive coccal and by the stick gram-negative flora, found out 21% patients Candida, in 6% – trichomonas, bacterial vaginosis – in 12%, with simultaneous all of patients have diminishing of amount of Lactobacillus, to complete absence in 23%. Application of Neotrizol allows attaining positive effect after an 8-daily course treatment in 87%, at continuation of treatment for patients with partial efficiency of the first course to 16 days – in 92%. A rapid effect for patients with the mixed base-line defeats of cervices determines the high estimation of efficiency and influence of treatment on a feel and quality of living by patients.
Key words: Neotrizol, base-line diseases of cervices.
Grek L. P., Zherzhova T. A.
Some aspects of the use of non-steroidal anti-inflammatory drugs for the pain syndrome in gynecology.
Carried out a comparative study of the efficacy and safety of drugs: Reumoxicam® (rectal suppositories), Diclofenac (rectal suppositories) and injecting analgesics in the treatment of pain syndrome in gynecology, associated with pelvic inflammatory diseases. Proven the same effectiveness of the drug in a dose of Reumoxicam® 15 mg and Diclofenac in a dose of 100 mg in eliminating pain. Established a favorable pharmacological profile, lack of gastrointestinal complications and good compliance of Reumoxicam® in comparison with Diclofenac and injection of pain medication.
Key words: pelvic inflammatory diseases, pain syndrome, Reumoxicam®, Diclofenac, inject analgesics, gastrointestinal complications, compliance.
Podolskiy V. V., Podolskiy Vl. V., Kagramanyan A. L., Novichenko A. V.
Psycho-emotional state of fertility women with reproductive health disorders living in rural region.
Results of investigation of psycho-emotional state of women in reproductive age with reproductive health disorders living in rural region were presented in the article. The emotional exhaustion and fatigue (35,0%), sleep disturbance (55,0%), constant anxiety (52,5%), high level of psycho-emotional stress (22,5%) and high indices of desadaptability (55,0%): discomposedly-depressive reactions (27,5%), mixt discomposedly-depressive disorders (12,5%) were observed in women with chronic genital diseases. (55,0%), sleep disturbance (47,5%), high (30,0%) and middle (47,5%) levels of psycho-emotional stress, high indices of desadaptability (52,5%): depressive reactions (22,5%), mixt discomposedly-depressive disorders (15,0%), hypochondria (10,0%) were discovered in women with sterility. Women with violations of menstrual cycle had the depressed mood (72,5%), emotional exhaustion and fatigue (67,5%), sleep disturbance (50,0%), high (42,5%) and middle (37,5%) levels of psycho-emotional stress, high indices of desadaptability (80,0%): unstable confusion (20,0%), hysterical disorder (12,5%), neurasthenia (15,0%). Ascertained changes allow to define path of medico-psychology correction.
Key words: psycho-emotional state, fertility, reproductive health, rural region.
Dubossarskaya Z. M., Greek L. P.
Rationale for treatment of patients with «proliferative syndrome» in gynecology.
Investigates the efficiency of treatment of patients with proliferative diseases of genitals (leymioma, endometriosis, endometrial hyperplasia) taking into account the expression of receptors to estradiol, progesterone, factor of the proliferation Ki-67. Determined the effectiveness of the proposed treatment based on clinical and morphological characteristics of pathology. This contributed to a reduction of clinical symptoms of the disease, duration of recurrence of proliferative process, pain syndrome 83.3 %, pregnancy 27,5 %.
Key words: leymioma, endometriosis, endometrial hyperplasia, expression of receptors to estradiol, progesterone, Кi-67.
Koblosh N. D.
The state of microecology of genital tracts in women with the pathology of uterus cervix.
In the article we may see the results of investigation of microecology of genital tracts in women with the pathology of uterus cervix. The outcomes specify the disorders of microecology of genital tracts in women with the benign diseases of uterus cervix following the proliferation of conditionally pathogenic flora, the increase of viral infection and the increase in the frequency of diagnostic of sexually transmitted infections.
Key words: pathology of uterus cervix, microecology of genital tracts, sexually transmitted infections.
Yuzko O. M., Rudenko N. G.
Infertility treatment with the use of assisted reproductive technologies in Ukraine.
The authors analyze the application of assisted reproductive technologies in Ukraine.
Key words: infertility, assisted reproductive technology.
Hinchytska L. V.
Clinical characteristic of menopausal manifestations in women with using non hormonal agents.
Clinical and laboratory examination of patients of menopausal age has been conducted to assess neurovegetative, emotional, endocrine and metabolic disorders and also the vaginal health index of these women. There are represented results of clinical manifestations of menopause before and after the application of non hormonal agents for three months. Here is highlighted the effectiveness of the proposed treatment.
Key words: menopause, clinical manifestations, treatment.
Gopchuk E. N.
Hepatoprotectors in adjuvant therapy urogenital trichomoniasis.
The article provides information about the relevance and effectiveness of treatment of urogenital trichomoniasis with use of hepatoprotector that increases effectiveness of base theraphy.
Key words: hepatoprotector, silimarin, Сarsil forte, trichomoniasis, treatment.
Priymak S. G., Andriets O. A.
Cytomegalovirus infection in the structure of perinatal complications.
Сlinical manifestations of CMV infections are minimum and can be determined as a routine acute respiratory disease. That’s why an appropriate laboratory examination and correct interpretation of the achieved data play an important role in timely diagnosis of the disease.
Key words: pregnancy, intrauterine infection, fetus, cytomegalovirus.
Fedorych P. V., Zelenyi S. B.
Trichomoniasis. The phenomenon of presence of Trichomonas tenax and Pentatrichomonas hominis in the genitourinary system of women of genesial age, patients by, sexual transmitted infections.
At research of secretions of the genitourinary system of man by an optical microscopy and Polymerase chain reaction simultaneously in a number of cases it was found out the presence of the simplest, which are not Trichomonas vaginalis. The objectives in this study to identify Trichomonas tenax and Pentatrichomonas hominis in the genitourinary system of women of patients by sexual transmitted infections. Methods – Real time Polymerase Chain Reaction. Of Trichomonas tenax and Pentatrichomonas hominis found out in the genitourinary system at 13 (43,3%) and 5 (16,7%) from women of genesial age, patients by, sexual transmitted infections. Тhe phenomenon of existence of Trichomonas tenax and Pentatrichomonas hominis is shown in the genitourinary system of women of genesial age, patients by, sexual transmitted infections
Key words: Trichomonas tenax, Pentatrichomonas hominis, Real time Polymerase Chain Reaction, genitourinary system, women of genesial age.
Hourani I. F., Kakar’kin A. Ya., Odarchenko P. Ya., Matsishevska I. V., Schneiderman P. Yu., Shevnya S. P., Korchystyy V. I.
Therapeutic pathomorphosis of breast cancer depending on the polychemotherapy scheme.
Research of therapeutic tumor pathomorphosis was conducted in 68 stage II–III breast cancer patients, after 6 neoadjuvant polychemotherapy (NAHT) courses by CAF and TAC schemes. Microscopically pathomorphosis appeared in degenerative and necrotic changes in the parenchyma of the of tumor cells polymorphism, fibrosis and tumor tissue hyalinosis. It was found that the treatment by the TAC scheme leads to better tumor mortalization, causing stage III–IV therapeutic pathomorphosis in 67% of patients, when during the CAF scheme treatment the tumor regression advanced in only 35.1% of patients. The most favorable response to chemotherapy was given by the infiltrative ductal carcinoma with overe xpression of HER-2 as well as tumors with a high degree of proliferation and lack of steroid receptors.
Key words: breast cancer, neoadjuvant polychemotherapy, pathomorphosis.
Severyn G. K.
Epidemiology of breast cancer among female population of the Donetsk region.
This research cast light on the question of epidemiology of breast cancer among female population in the Donetsk region in the period from 2007 to 2011. It was established the tendency to increase of breast cancers cases with growth of detection in both urban and rural areas, female patients with breast cancer with increasing index of morphological verification of diagnosis, the increase or this index is determined by improving the efficiency of specialized cancer care, it is proved by decrease of one-year mortality and five year survival index of this category of patients.
Key words: women, the Donetsk region, breast cancer, morbidity, mortality.
Мигрень: женская болезнь.