- Prophylactics of obstetric disorders in anemia of chronic disease
Prophylactics of obstetric disorders in anemia of chronic disease
PERINATOLOGIYA I PEDIATRIYA. 2017.2(70):37-41; doi 10.15574/PP.2017.70.37
Davydova Iu. V., Ogorodnyk A. A., Limancka A. Yu., Bayder A. K., Butenko L. P.
SI «Institute of Pediatrics, Obstetrics and Gynecology of NAMS of Ukraine», Kyiv
The article presents data of the pathogenesis, clinical peculiarities and treatment of anemia of chronic disease observed in inflammatory, infectious and oncological diseases. The main biomarkers, diagnostic tools, and risks of anemia of chronic disease in pregnant women with chronic diseases are analyzed in the article. Anemia of chronic disease makes a significant contribution to increasing incidence of obstetric disorders in pregnants with inflammatory, autoimmune, infectious, malignant diseases. The pathogenesis of anemia of chronic disease, with the key role of hepcidin in the regulation of iron absorption and release is presented. Proper analysis of inflammation and anemia biomarkers allows developing the efficacious therapeutic approach to anemia of chronic disease in pregnant women. The intravenous iron therapy in this group of pregnant women is appropriate and allows to achieve the rapid effect in the treatment of anemia with a high safety profile.
Key words: anemia of chronic inflammation, autoimmune diseases, pregnancy, hepcidin, biomarkers of anemia, intravenous iron.
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