• Probiotics with vitamin D3 in the prevention of infectious disease in premature infants

Probiotics with vitamin D3 in the prevention of infectious disease in premature infants

SOVREMENNAYA PEDIATRIYA.2017.1(81):39-44; doi 10.15574/SP.2017.81.39

Aryaev N. L., Shevchenko I. M., El-Mezewghi H. M., Shevchenko N. V.
Odessa National Medical University, Ukraine
Maternity Hospital №7, Odessa, Ukraine

Objective: to study of the efficacy of vitamin D3 and probiotics for the prevention of infectious disease in premature infants.

Material and methods. This study was conducted by the Odessa National Medical University — the Neonatology Department of the Maternity Hospital No.7, Odessa, Ukraine. The first group included 20 preterm infants who received BioGaia drops. The second group included 19 preterm infants who received BioGaia drops with vitamin D3. The control group included 23 premature infants, did not receive the above-mentioned drugs. At birth and at 3–4 months they underwent a comprehensive immunological research and the morbidity was monitored monthly.

Results. The effectiveness of the drugs was evaluated by studying the disease in groups and all parameters of the immunogram was balanced. The highest change was observed in the control group, while change in the first and the second group did not differ significantly from each other. Premature infants who did not receive the Probiotic and vitamin D3, showed an increase in the rate of infectious diseases , vitamin D3 deficiency and intestinal colic 1.2–1.8, 2.29 and 1.36 times, respectively. The results of the research show that for the best results the combination of Probiotics and Vitamin D3 is necessary for prophylaxis in the immunity of preterm infants.

Key words: immunity, premature infants, probiotics, vitamin D3, prevention, infectious diseases.


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