• Predictive risk of aneuploidies during future pregnancies, depending on the number of previous reproductive loss and maternal age

Predictive risk of aneuploidies during future pregnancies, depending on the number of previous reproductive loss and maternal age

HEALTH OF WOMAN. 2016.10(116):28–32 
 

Predictive risk of aneuploidies during future pregnancies, depending on the number of previous reproductive loss and maternal age


Veropotvelyan N. P.

The «Inter-provincial center of medical genetics and prenatal diagnosis», Krivoy Rog


The article presents data and analysis of their studies on the prevalence of chromosomal aberrations as a whole and separately for different aneuploidy types of missed abortions with first trimester (n = 1808), depending on maternal age and number of previous reproductive losses. According to the results we can mention that: risk to have missed abortion of meiotic aneuploidy and mitotic origin as a whole increased 5.6 times for women over 40 compared to women of 40 years (OR = 5.644) .; regardless of age and women have the following risk of aneuploid pregnancy in the first episode SA / MA two times higher than the subsequent (OR = 2.023 -2.232); after 35 years following risks to have missed abortion with aneuploidy halved if there is a history of three or more pregnancy losses.


Key words: missed abortion, chromosomal abnormalities, maternal age, number of SA episodes.


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