• Predictive risk of aneuploidies during future pregnancies, depending on the number of previous reproductive loss and maternal age

Predictive risk of aneuploidies during future pregnancies, depending on the number of previous reproductive loss and maternal age

HEALTH OF WOMAN. 2016.10(116):28–32 

Predictive risk of aneuploidies during future pregnancies, depending on the number of previous reproductive loss and maternal age

Veropotvelyan N. P.

The «Inter-provincial center of medical genetics and prenatal diagnosis», Krivoy Rog

The article presents data and analysis of their studies on the prevalence of chromosomal aberrations as a whole and separately for different aneuploidy types of missed abortions with first trimester (n = 1808), depending on maternal age and number of previous reproductive losses. According to the results we can mention that: risk to have missed abortion of meiotic aneuploidy and mitotic origin as a whole increased 5.6 times for women over 40 compared to women of 40 years (OR = 5.644) .; regardless of age and women have the following risk of aneuploid pregnancy in the first episode SA / MA two times higher than the subsequent (OR = 2.023 -2.232); after 35 years following risks to have missed abortion with aneuploidy halved if there is a history of three or more pregnancy losses.

Key words: missed abortion, chromosomal abnormalities, maternal age, number of SA episodes.


1. Boue J, Bou A, Lazar P. 1975. Retrospective and prospective epidemiological studies of 1500 karyotyped spontaneous human abortions. Teratology 12:11–26. https://doi.org/10.1002/tera.1420120103; PMid:1162621

2. Hassold T, Chen N, Funkhouser J, Jooss T, Manuel B, Matsuura J et al. 1980. A cytogenetic study of 1000 spontaneous abortions. Ann Hum Genet 44:151–178. https://doi.org/10.1111/j.1469-1809.1980.tb00955.x; PMid:7316468

3. Hassold T, Chiu D. 1985. Maternal age-specific rates of numerical chromosome abnormalities with special reference to trisomy. Hum Genet 70:11–17. https://doi.org/10.1007/BF00389450; PMid:3997148

4. Kline J, Stein Z. 1987. Epidemiology of Chromosomal Anomalies in Spontaneous Abortion: Prevalence, Manifestation and Determinants. In: Bennett MJ, Edmonds DK, editors. Spontaneous and Recurrent Abortion. Chicago: Oxford Blackwell Scientific: 29–50.

5. Menasha J, Levy B, Hirschhorn K, Kardon NB. 2005. Incidence and spectrum of chromosome abnormalities in spontaneous abortions: New insights from a 12-year study. Genetics in Medicine 7:251–263. https://doi.org/10.1097/01.GIM.0000160075.96707.04; PMid:15834243

6. Dobroohotova YuE, Dzhobava EM, Ozerova RI. 2010. Nerazvivayuschayasya beremennost. M, Geotar-media:144.

7. Recurrent pregnancy loss causes, controversies and treatment/ edited by Howard JA Carр. CRC Press. 2007.

8. Hook EB. 1981, Sep. Rates of chromosome abnormalities at different maternal ages. Obstet Gynecol. 58(3):282–5. PMid:6455611

9. Hook EB, Cross PK, Schreinemachers DM. 1983. Chromosomal abnormality rates at amniocentesis and in live-born infants. JAMA. 249(15):2034-8. https://doi.org/10.1001/jama.1983.03330390038028https://doi.org/10.1001/jama.249.15.2034; PMid:6220164.

10. Young Joo Kim, Jee Eun Lee, Soo Hyun Kim, Sung Shin Shim. 2013, May. Maternal age-specific rates of fetal chromosomal abnormalities in Korean pregnant women of advanced maternal age. Obstet Gynecol Sci. 56(3):160–166. Published online 2013 May 16. https://doi.org/10.5468/ogs.2013.56.3.160; PMCID: PMC3784117.

11. Schreinemachers DM, Cross PK, Hook EB. 1982. Rates of trisomies 21, 18, 13 and other chromosome abnormalities in about 20 000 prenatal studies compared with estimated rates in live births. Hum. Genet. 61(4):318-24. https://doi.org/10.1007/BF00276595; PMid:6891368.

12. Hill MA. (2016) Embryology Genetic risk maternal age. Retrieved November 9, 2016. from https://embryology.med.unsw.edu.au/embryology/index.php/Genetic_risk_maternal_age

13. Nuriev N.R. Vozrast i besplodie: obyazatelnyiy minimum svedeniy http: //www. nnplus. ru/treatment/vozrost_besplodie/

14. Carp H. 12–13.05. 2016. Kyiv. Naukovo-praktichna konferentsiya z mizhnarodnoyu uchastyu «Suchasni aspekty vidnovlennya ta zberezhennya zdorov’ya zhinki».

15. Warburton D, Kline J, Stein Z et al. 1987. Does the karyotype of a spontaneous abortion predict the karyotype of subsequent abortion? Evidance from 273 women with two karyotyped spontaneous abortions. Am J Hum Genet 41:465–83. PMid:3631080 PMCid:PMC1684190

16. Stern С, Chamley L et al. 1998. Antibodies to b2 glycoproteine I are associated with in vitro fertilization implantation failure as well as recurrent miscarriage: result of a prevalence study. Fertil Sterile 70:938–44. https://doi.org/10.1016/S0015-0282(98)00312-4

17. Stepherson MD, Awartani KA, Robinson WP. 2002. Cytogenetic analysis of miscarriage from couples with recurrent miscarriages: a case-control study. Hum Reprod 17:446–51. https://doi.org/10.1093/humrep/17.2.446

18. Carp H, Toder V, Aviram A et al. 2001. Karyotype of the abortus in recurrent miscarriage. Fertil Steril 75:678–82. https://doi.org/10.1016/S0015-0282(00)01801-X

19. Ogasawara M, Aoki K, Okada S et al. 2000. Embryonic karyotype of abortuses in relation to the namber of previous miscarriages. Fertile Steril 73:300–4. https://doi.org/10.1016/S0015-0282(99)00495-1

20. Hassold TJ, Matsuyama A et al. 1978. A cytogenetic study of spontaneous abortion in Hawaii. Ann Hum Genet 41:443–54. https://doi.org/10.1111/j.1469-1809.1978.tb00914.x

21. Munne S, Sandalinas M, Magli C et al. 2004. Increased rateof aneuploidy embryos in young women with previous aneuploidy conception. Prenat Diagn 24:638–43. https://doi.org/10.1002/pd.957; PMid:15305354

22. Robio C, Simon C et al. 2003. Chromosomal abnormalities and embryo developmemt in recurrent miscarriage couples. Hum Reprod 18:182–8. https://doi.org/10.1093/humrep/deg015

23. Choi TY, Lee HM, Park WK, Jeong SY, Moon HS. 2014, Nov. Spontaneous abortion and recurrent miscarriage: A comparison of cytogenetic diagnosis in 250 cases. Obstet Gynecol Sci. 57(6):518-25. doi: 10.5468 /ogs. 2014. 57.6.518. Epub 2014 Nov 20.

24. Hassold T, Merrill M, Adkins K et al. 1995. Recombanation and maternal-age – dependent nondisjunction: molecular studies of trisomy 16. Am J Hum Genet 57:867–74. PMid:7573048 PMCid:PMC1801507

25. Fisher JM, Harvey JE, Morton NE et al. 1995. Trisomy 18: studies of the parent and cell division of origin and the effect of aberrant recombination on nondisjunction. Am J Hum Genet 56:669–75. PMid:7887421 PMCid:PMC1801162

26. Hall HE, Surti U, Hoffner L, Shirley S, Feingold E, Hassold T. 2007. The origin of trisomy 22: evidence for acrocentric chromosome-specific patterns of nondisjunction. Am J Med Genet A. 143A:2249–2255. https://doi.org/10.1002/ajmg.a.31918; PMid:17705154