• Preconception prophylactic of the urinary tract infection in women of high1risk groups: reserves to reduce perinatal and obstetric complications 

Preconception prophylactic of the urinary tract infection in women of high1risk groups: reserves to reduce perinatal and obstetric complications 

PERINATOLOGIYA I PEDIATRIYA. 2016.2(66):28-31; doi 10.15574/PP.2016.66.28 
 

Preconception prophylactic of the urinary tract infection in women of high1risk groups: reserves to reduce perinatal and obstetric complications 
 

Limanskaya A., Shevchuk E., Ogorodnyk A., Davydova Yu

SI «Institute of Pediatrics, Obstetrics, Gynecology, is the NAMS of Ukraine» Kiev, Ukraine 
 

The aim of the study is to reveal the effectiveness of «Novoks» manufacturing by Organosin companies in preconception treatment of urinary tract infections in women with lupus nephritis and pyelonephritis gestational history. 
 

Material and methods. The study involved 30 women with gestational pyelonephritis history and 15 women with lupus nephritis. Inclusion criteria were the presence of at least one of the clinical symptoms (pain in the lumbar region, dysuria, pain in the PST region) in conjunction with microbiological criteria: number of leukocytes in the urine over a field of view of 10–15; the number of colony forming units of a microorganism > 104; sensitivity to levofloxacin as a result of urine culture. Inclusion criteria: urinalysis, urine culture with antibiotic susceptibility, clinical and biochemical blood tests, an ultrasound examination of the kidneys). All women received the drug Novaks (Organosin) 500 mg once daily for 5–7 days, and the probiotic Probiz Femina 1 capsule 2 times per day till 14 days. 
 

Results. After a treatment with Novaks in combination with a probiotic Probiz-Femina (Organosin) noted a progressive decrease in the degree of bacteriuria, which was manifested during a urine test research absence of bacteria and decrease the number of white blood cells. Also regressed inflammatory changes in the peripheral blood. During the control urine culture after 10 days of treatment and 1 month later, revealed no growth of pathogenic organisms in the relevant titer. 
 

Conclusions. Novoks (levofloxacin) is recommended for use in preconception prevention and treatment of infectious diseases of the urinary system in women at high risk. Using microbial interference therapy using modern probiotic Probiz Femina leads to a significant improvement in intestinal microbiocenosis in antibiotic therapy, reduce contamination of the intestines and the vagina, which allows you to take drug treatment Novaks without impairing the quality of life. 
 

Keywords: preconception prophylactic, urinary tract infections, lupus nephritis, gestational pyelonephritis, Novoks, Probiz Femina, levofloxacin. 
 

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