• Plasma concentrations of endothelin-1 and C-natriuretic peptide of pregnant women with gestational hypertension

Plasma concentrations of endothelin-1 and C-natriuretic peptide of pregnant women with gestational hypertension

PERINATOLOGIYA I PEDIATRIYA. 2017.1(69):46-50; doi 10.15574/PP.2017.69.46

Plasma concentrations of endothelin-1 and C-natriuretic peptide of pregnant women with gestational hypertension

Bulavenko O. V., Vaskiv O. V.

National Pirogov Memorial Medical University, Ukraine

Purpose — to evaluate the peculiarities of endothelial vasoregulation properties in pregnant women with gestational hypertension, by detecting the serum concentrations of endothelin-1and C-natriuretic peptide and their ratio.

Materials and methods. Total 61 pregnant women were examined and subdivided into three groups. The first group comprised pregnant women with gestational hypertension (n=22), the second group included women with preeclampsia (n=20), and women with normal pregnancy belonged to group III, which was a control group (n=19). The method of enzyme-linked immunoassay by means of reagents of the company «Biomedica» (Germany) was applied to detect the concentration of endothelin-1 and C-natriuretic peptide in the serum of patients.

Results. Serum levels of endothelin-1 and C-natriuretic peptide was significantly higher in women with gestational hypertension (29.1±2.84 pg/ml and 12.2±1.24 ng/ml, respectively) and in the second group of women with preeclampsia (38.1±2.82 pg/ml and 9.1±0.90 ng/ml, respectively) compared with the rates in the control group (15.86±2.10 pg /ml and 6.95±0.68 ng/ml, respectively). There was observed imbalance in the constructor/vasodilator system in patients with preeclampsia resulted in the higher endothelin-1 concentration in blood serum than the C-natriuretic peptide, which is evidenced by the results of their ratio. In particular, their ratio was significantly higher in pregnant women with preeclampsia than in the control group (p<0.05). Pregnant women with gestational hypertension had this ratio slightly higher in comparison with the control group, which can be viewed as a compensatory adaptation due to the increase of C-natriuretic peptide concentration in response to increased production of endothelin-1.

Conclusions. Our analysis suggests that endothelial dysfunction is a characteristic feature of the pregnant women with hypertensive disorders evidenced by the imbalance of vasoregulatory factors, namely by prevailing of the vasoconstrictor component over the vasodilation one.

Key words: gestational hypertension, endothelial dysfunction, endothelin-1, C-natriuretic peptide.

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