• Pharmacology of vitamin D

Pharmacology of vitamin D

SOVREMENNAYA PEDIATRIYA.2017.2(82):28-36; doi 10.15574/SP.2017.82.28

Chekman I. S., Gorchakova N. A., Berezhniy V. V., Davydiuk A. V., Roman'ko M. R.
Kyiv Medical University, Ukraine
Bogomolets National Medical University, Kiev, Ukraine
Shupyk National Medical Academy of Postgraduate Education, Kiev, Ukraine

In a review article shows the route of entry and the role of vitamin D in the human body. To date the vitamin D deficiency is common to the majority of human population. The medicines that used to correct hypovitaminosis D, in the market of Ukraine, are presented in the form of oil and water solutions of vitamin D, as well as vitamin D-containing vitamin complexes.

Key words: vitamin D, metabolism, vitamin deficiency, prevention, treatment.

References

1. Abaturov AE, Zavgorodnyaya NYu. 2012. Vitamin-D-zavisimaya produktsiya antimikrobnyih peptidov. Zdorovia dytyny. 1(36): 20—21.

2. Hanzhyi IIu. 2013. Kliniko-patohenetychne obgruntuvannia profilaktyky ta likuvannia syndromu polikistoznykh yaiechnykiv u zhinok riznykh vikovykh hrup. Avtoref dys … kand med nauk. DU «Instytut pediatrii, akusherstva i hinekolohii NAMN Ukrainy». Kyiv: 36.

3. Kvashnina LV. 2013. Imunomoduliuiuchi efekty vitaminu D u ditei. Zdorovia dytyny. 7.

4. Komisarenko YuI. 2013. Vitamin D ta yoho rol u rehuliatsii metabolichnykh rozladiv. Lektsii, ohliady, novyny. 4: 51—54.

5. Maydannik VG. 2014. Klinicheskie rekomendatsii po diagnostike, lecheniyu i profilaktike vitamin D-defitsitnogo rahita u detey. Kiev: 58.

6. Tatarchuk TF, Zadorozhnaya TD, Kapshuk IN et al. 2015. Morfologicheskie osobennosti yaichnikov kryis pri eksperimentalnom D3 gipovitaminoze. Zdorove zhenschinyi. 1(97): 195-198.

7. Semin SG, Volkova LV, Moiseev AB, Nikitina NV. 2012. Perspektivyi izucheniya biologicheskoy roli vitamina D. Pediatriya Zhurnal im GN Speranskogo. 91(2): 122—131.

8. Povorozniuk VV, Balatska NI. 2013. Defitsyt vitaminu D u naselennia Ukrainy ta chynnyky ryzyku yoho rozvytku. Reprodukt endokrynol. 5(13): 7—13.

9. Povoroznyuk VV. 2013. Sostoyanie problemyi osteoporoza i drugih metabolicheskih zabolevaniy skeleta v Ukraine. Nov med farmats. 3(487): 10—13.

10. Shvarts GYa. 2009. Vitamin D, D-gormon i alfakaltsidiol: meditsinskie, molekulyarno-biologicheskie i farmakologicheskie aspektyi. Ukr revmatol zhurn. 3: 63—69

11. Gysemans CA, Cardozo AK, Callewaert H et al. 2005. 1.25-Dihydroxyvitamin D3 modulates expression of chemokines and cytokines in pancreatic islets: implications for prevention of diabetes in non-obese diabetic mice. Endocrinology. 146(4): 1956—1964. https://doi.org/10.1210/en.2004-1322; PMid:15637289

12. Cardus A, Panizo S, Encinas M et al. 2009. 1.25-dihydroxyvitamin D3 regulates VEGF production through a vitamin D response element in the VEGF promoter. Atherosclerosis. 204(1): 85—89. https://doi.org/10.1016/j.atherosclerosis.2008.08.020; PMid:18834982

13. Soderstrom LH, Johnson SP, Diaz VA, Mainous AG. 2012. 3-d. Association between vitamin D and diabetic neuropathy in a nationally representative sample: results from 2001—2004 NHANES. Diabet Med. 29(1): 50—55. https://doi.org/10.1111/j.1464-5491.2011.03379.x; PMid:21726279 PMCid:PMC3461835

14. Nimptsch K, Platz EA, Willett WC, Giovannucci E. 2012. Association between plasma 25-OH vitamin D and testosterone levels in men. Clin Endocrinol (Oxf). 77(1): 106—112. https://doi.org/10.1111/j.1365-2265.2012.04332.x; PMid:22220644 PMCid:PMC3712348

15. Lee HS, Kim YJ, Shim YS et al. 2014. Associations between serum vitamin D levels and precocious puberty in girls. Ann Pediatr Endocrinol Metab. 19(2): 91—95. https://doi.org/10.6065/apem.2014.19.2.91; PMid:25077092 PMCid:PMC4114046

16. Forouhi NG, Luan J et al. 2008. Baseline serum 25-hydroxy vitamin d is predictive of future glycemic status and insulin resistance: the Medical Research Council Ely Prospective Study 1990-2000. Diabetes. 57: 2619—2625. https://doi.org/10.2337/db08-0593; PMid:18591391 PMCid:PMC2551670

17. Bikle D. 2009. Nonclassic actions of vitamin D. J Clin Endocrinol Metab. 94: 26—34. https://doi.org/10.1210/jc.2008-1454; PMid:18854395 PMCid:PMC2630868

18. Billaudel BJ, Faure AG, Sutter BC. 1990. Effect of 1,25dihydroxyvitamin D3 on isolated islets from vitamin D3-deprived rats. Am J Physiol. 258; 4 Pt 1: 643—648.

19. Bodnar LM, Krohn MA, Simhan HN. 2009. Maternal vitamin D deficiency is associated with bacterial vaginosis in the first trimester of pregnancy. J Nutr. 139(6): 1157—1161. https://doi.org/10.3945/jn.108.103168; PMid:19357214 PMCid:PMC2682987

20. Brock KE, Huang WY. 2011. Diabetes prevalence is associatedwith serum 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D in US middle-aged Caucasian men and women: a cross-sectional analysis within the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. Br J Nutr. 106(3): 339—344. https://doi.org/10.1017/S0007114511001590; PMid:21736838 PMCid:PMC3515777

21. Sooy K, Schermerhorn T, Noda M et al. 1999. Calbindin-D (28k) controls [Ca(2+)](i) and insulin release. Evidence obtained from calbindin-D(28k) knockout mice and beta cell lines. J Biol Chem. 274(48): 34343—34349. https://doi.org/10.1074/jbc.274.48.34343; PMid:10567411

22. Castro LC. 2011. The vitamin D endocrine system. Arq Bras Endocrinol Metabol. 55(8): 566-575. https://doi.org/10.1590/S0004-27302011000800010; PMid:22218438

23. Maghbooli Z, Hossein-Nezhad A, Karimi F et al. 2008. Correlation between vitamin D3 deficiency and insulin resistance in pregnancy. Diabetes Metab Res Rev. 24(1): 27—32. https://doi.org/10.1002/dmrr.737; PMid:17607661

24. Wortsman J, Matsuoka LY, Chen TC et al. 2000. Decreased bioavailability of vitamin D in obesity. Amer J Clin Nutr. 72: 690—693. PMid:10966885

25. Sheth JJ, Shah A, Sheth FJ et al. 2015. Does vitamin D play a significant role in type 2 diabetes? BMC Endocr Disord. 15: 5. https://doi.org/10.1186/s12902-015-0003-8; PMid:25887335 PMCid:PMC4357062

26. Evans KN, Nguyen L, Chan J et al. 2006. Effects of 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 on cytokine production by human decidual cells. Biol Reprod. 75(6): 816-822. https://doi.org/10.1095/biolreprod.106.054056; PMid:16957024

27. Holick MF, Binkley NC, Bischoff-Ferrari HA et al. 2011. Endocrine Society. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 96(7): 1911—1930. https://doi.org/10.1210/jc.2011-0385; PMid:21646368

28. Bischoff-Ferrari HA, Giovannucci E, Willett WC. 2006. Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes. Am J Clin Nutr. 84(1): 18-28. PMid:16825677

29. Chen TC, Chimeh F, Lu Z et al. 2007. Factors that influence the cutaneous synthesis and dietary sources of vitamin D. Arch Biochem Biophys. 460(2): 213—217. https://doi.org/10.1016/j.abb.2006.12.017; PMid:17254541 PMCid:PMC2698590

30. Baker AM, Haeri S, Camargo CA et al. 2011. First-trimester maternal vitamin D status and risk for gestational diabetes (GDM) a nested case-control study. Diabetes Metab Res Rev. 28(2): 164-168. https://doi.org/10.1002/dmrr.1282; PMid:21818838 PMCid:PMC4381548

31. Forouhi NG, Ye Z. 2012. Circulating 25-hydroxyvitamin D concentration and the risk of type 2 diabetes: results from the European Prospective Investigation into Cancer (EPIC)-Norfolk cohort and updated meta-analysis of prospective studies. Diabetologia. 55(8): 2173—2182. https://doi.org/10.1007/s00125-012-2544-y; PMid:22526608

32. Saraf R, Morton SM, Camargo CAJr, Grant CC. 2015, Sep 15. Global summary of maternal and newborn vitamin D status — a systematic review. Matern Child Nutr. Epub ahead of print. PMid:26373311

33. Grundmann M, von Versen-Hoynck F. 2011. Vitamin D-roles in women's reproductive health? Reprod Biol Endocrinol. 9: 146. https://doi.org/10.1186/1477-7827-9-146; PMid:22047005 PMCid:PMC3239848

34. Heaney RP. 2008. Vitamin D in health and disease. Clin J Am Soc Nephrol. 3(5): 1535—1541. https://doi.org/10.2215/CJN.01160308; PMid:18525006 PMCid:PMC4571146

35. Holick MF. 2007. Vitamin D deficiency. N Engl J Med. 357(3): 266—281. https://doi.org/10.1056/NEJMra070553; PMid:17634462

36. Maestro B, Da’vila N, Carranza MC, Calle C. 2003. Identification of a vitamin D response element in the human insulin receptor gene promoter. J Steroid Biochem Molecul Biol. 84: 223-230. https://doi.org/10.1016/S0960-0760(03)00032-3

37. Donoso MA, Munoz-Calvo MT, Barrios V et al. 2009. Increased circulating adiponectin levels and decreased leptin/soluble leptin receptor ratio throughout puberty in female ballet dancers: association with body composition and the delay in puberty. Eur J Endocrinol. 162(5): 905—911. https://doi.org/10.1530/EJE-09-0874; PMid:20145046

38. Ranjzad F, Mahban A, Shemirani AI et al. 2011. Influence of gene variants related to calcium homeostasis on biochemical parameters of women with polycystic ovary syndrome. J Assist Reprod Genet. 28(3): 225—232. https://doi.org/10.1007/s10815-010-9506-4; PMid:21082232 PMCid:PMC3082662

39. Dawson-Hughes B, Mithal A, Bonjour JP et al. 2010. IOF position statement: vitamin D recommendations for older adults. Osteoporos Int. 21(7): 1151—1154. https://doi.org/10.1007/s00198-010-1285-3; PMid:20422154

40. Jones G. 2008. Pharmacokinetics of vitamin D toxicity. Am J Clin Nutr. 88: 582—586.

41. Ju SY, Jeong HS, do Kim H. 2014. Blood vitamin D status and metabolic syndrome in the general adult population: a dose-response meta-analysis. J Clin Endocrinol Metab. 99(3): 1053-1063. https://doi.org/10.1210/jc.2013-3577; PMid:24423309

42. Kamycheva ER, Joakimsen M, Jorde R. 2003. Intakes of calcium and vitamin D predict body mass index in the population of Northern Norway. J Nutr. 133: 102—106. PMid:12514276

43. Hahn S, Haselhorst U, Tan S et al. 2006. Low serum 25-hydroxyvitamin D concentrations are associated with insulin resistance and obesity in women with polycystic ovary syndrome. Exper Clin Endocrinol Diab. 114: 577—583. https://doi.org/10.1055/s-2006-948308; PMid:17177140

44. Mathieu C, Gysemans C. 2006. Vitamin D and diabetes. Av Diabetol. 22(3): 187—193.

45. Mithal A. 2014. Treatment of vitamin D deficiency. Endocrine case management ICE/ENDO 2014 Meet-the professor, Endocrine society: 37—39.

46. Morris HA, Anderson PH. 2010. Autocrine and paracrine actions of vitamin D. Clin Biochem Rev. 31(4): 129—138. PMid:21170259 PMCid:PMC2998276

47. Pittas AG, Sun Q, Manson JE. 2010. Plasma 25-hydroxyvitamin D concentration and risk of incident type 2 diabetes in women. Diabetes Care. 33(9): 2021—2023. https://doi.org/10.2337/dc10-0790; PMid:20805275 PMCid:PMC2928356

48. Gomez de Tejada Romero MJ, Sosa Henriquez M, Del Pino Montes J et al. 2011. Position document on the requirements and optimum levels of vitamin D. Rev Osteoporos Metab Miner. 1: 53—64.

49. Ozkan S, Jindal S, Greenseid K et al. 2009. Replete vitamin D stores predict reproductive success following in vitro fertilization. Fertil Steril. 94(4): 1314—1319. https://doi.org/10.1016/j.fertnstert.2009.05.019; PMid:19589516 PMCid:PMC2888852

50. Thomson RL, Spedding S, Brinkworth GD et al. 2013. Seasonal effects on vitamin D status influence outcomes of lifestyle intervention in overweight and obese women with polycystic ovary syndrome. Fertil Steril. 99(6): 1779—1785. https://doi.org/10.1016/j.fertnstert.2012.12.042; PMid:23357457

51. Lau SL, Gunton JE, Athayde NP et al. 2013. Serum 25-hydroxyvitamin D and glycated haemoglobin levels in women with gestational diabetes mellitus. Med J Aust. 194(7): 334—337.

52. Shipton EE, Shipton EA. 2015. Vitamin D deficite and pain. Pain Ther. 4(1): 67—87. https://doi.org/10.1007/s40122-015-0036-8; PMid:25920326 PMCid:PMC4470966

53. Shoelson SE, Herrero L, Naaz A. 2007. Obesity, inflammation, and insulin resistance. Gastroenterol. 132: 2169—2180. https://doi.org/10.1053/j.gastro.2007.03.059; PMid:17498510

54. Smolikova K, Mlynarcikova A, Scsukova S. 2013. Effect of 1α,25-dihydroxyvitamin D3 on progesterone secretion by porcine ovarian granulosa cells. Endocr Regul. 47(3): 123—131. https://doi.org/10.4149/endo_2013_03_123; PMid:23889482

55. Rashidi B, Haghollahi F, Shariat M, Zayerii F. 2011. The effects of calcium — vitamin D and metformin on polycystic ovary syndrome: a pilot study. Taiwan J Obstet Gynecol. 48(2): 142—147. https://doi.org/10.1016/S1028-4559(09)60275-8

56. Procopio M, Magro G, Cesario F et al. 2002. The oral glucose tolerance test reveals a high frequency of both impaired glucose tolerance and undiagnosed Type 2 diabetes mellitus in primary hyperparathyroidism. Diabet Med. 19: 958—961. https://doi.org/10.1046/j.1464-5491.2002.00809.x; PMid:12421435

57. Krul-Poel YH, Snackey C, Louwers Y et al. 2013. The role of vitamin D in metabolic disturbances in polycystic ovary syndrome: a systematic review. Eur J Endocrinol. 169(6): 853-865. https://doi.org/10.1530/EJE-13-0617; PMid:24044903

58. Khoo AL, Chai L, Koenen H et al. 2012. Translating the role of vitamin D3 in infectious diseases. Crit Rev Microbiol. 38(2): 122—135. https://doi.org/10.3109/1040841X.2011.622716; PMid:22304022

59. Liu NQ, Kaplan AT, Lagishetty V et al. 2011. Vitamin D and the regulation of placental inflammation. J Immunol. 186(10): 5968—5974. https://doi.org/10.4049/jimmunol.1003332; PMid:21482732

60. Gilbert-Diamond D, Baylin A, Mora-Plazas M et al. 2010. Vitamin D deficiency and anthropometric indicators of adiposity in school — age children: a prospective studyю  Am J Clin Nutr. 92(6): 1446—1451. https://doi.org/10.3945/ajcn.2010.29746; PMid:20926524 PMCid:PMC3131841

61. Bischoff-Ferrari HA, Burckhardt P, Quack-Loetscher K et al. 2012. Vitamin D deficiency: Evidence, safety, and recommendations for the Swiss population. Report written by a group of experts on behalf of the Federal Commission for Nutrition (FCN). PMCid:PMC3319875

62. Pludowski P, Holick MF, Pilz S et al. 2013. Vitamin D effects on musculoskeletal health, immunity, autoimmunity, cardiovascular disease, cancer, fertility, pregnancy, dementia and mortality — a review of recent evidence. Autoimmun Rev. 12(10): 976—989. https://doi.org/10.1016/j.autrev.2013.02.004; PMid:23542507

63. Compston JE, Vedi S, Ledger JE et al. 1981. Vitamin D status and bone histomorphometry in gross obesity. Amer J Clinical Nutr. 34: 2359—2363. PMid:7304477

64. Hollis BW, Johnson D, Hulsey TC et al. 2011. Vitamin D supplementation during pregnancy: double-blind, randomized clinical trial of safety and effectiveness. J Bone Miner Res. 26(10): 2341—2357. https://doi.org/10.1002/jbmr.463; PMid:21706518 PMCid:PMC3183324

65. Reis JP, von Muhlen D, Kritz-Silverstein D et al. 2007. Vitamin D, parathyroid hormone levels, and the prevalence of metabolic syndrome in community-dwelling older adults. Diabetes Care. 30(6): 1549—1555. https://doi.org/10.2337/dc06-2438; PMid:17351276

66. Christakos S, Dhawan P, Benn B et al. 2007. Vitamin D: molecular mechanism of action. Ann N Y Acad Sci. 1116: 340—348. https://doi.org/10.1196/annals.1402.070; PMid:18083936

67. Wehr E, Trummer O, Giuliani A et al. 2011. Vitamin D-associated polymorphisms are related to insulin resistance and vitamin D deficiency in polycystic ovary syndrome. Eur J Endocrinol. 164(5): 741—749. https://doi.org/10.1530/EJE-11-0134; PMid:21389086

68. Wehr E, Pieber TR, Obermayer-Pietsch B. 2011. Effect of vitamin D3 treatment on glucose metabolism and menstrual frequency in polycystic ovary syndrome women: a pilot study. J Endocrinol Invest. 34(10): 757—763. PMid:21613813

Содержание журнала Full text of article