• Perinatal aspects of child’s immune status

Perinatal aspects of child’s immune status

PERINATOLOGIYA I PEDIATRIYA. 2017.1(69):95-102; doi 10.15574/PP.2017.69.95

Perinatal aspects of child's immune status

Makarenko M. V., Govseev D. A., Berestoviy V. O., Sokol I. V., Vorona R. M.
Kyiv Meternity Hospital No 5, Ukraine

Purpose — to summarize literature data of the last 30 years on the current understanding of the immune aspects of the mother-placenta-fetus system formation and function; focus on the development of fetal immune system (Immunculus), depending on the mother's immune load.

Materials and methods. Cord blood and peripheral blood were sampled from 19 pregnant women and their newborns, depending on the term of gestation, to measure the levels of IgG and IgM antibodies. Human's HSP60 was used as an antigen. Obtained results provide information about formation of the fetal immune status during pregnancy under the influence of maternal antigens, including IgG. Due to the latter, the fetus produces IgM autoantibody for fast presentation and recognition of foreign antigens.

Conclusions. The assumption on the possible mechanisms of preterm birth was made by the authors.

Key words: Immunculus, IgG, IgM, autoantibody, epigenetic immune imprinting, HSP60.


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