• The pathology of eclampsia:An autopsy series

The pathology of eclampsia:An autopsy series

HEALTH OF WOMAN. 2017.6(122):152–157

Jonathan L. Hecht, Jaume Ordi, Carla Carrilho, Mamudo R. Ismail, Zsuzsanna K. Zsengeller, S. Ananth Karumanchi, and Seymour Rosen
Abridged version. Adapted – S.A. Shurpyak


1. Duley L. 2009. The Global Impact of Pre-Eclampsia and Eclampsia, Semin. Perinatol. 33:130–137. https://doi.org/10.1053/j.semperi.2009.02.010; PMid:19464502

2. Powe CE, Levine RJ and Karumanchi SA. 2011. Preeclampsia. A Disease of the Maternal Endothelium: The Role of Antiangiogenic Factors and Implications for Later Cardiovascular Disease, Circulation. 123:2856–2869. https://doi.org/10.1161/CIRCULATIONAHA.109.853127; PMid:21690502 PMCid:PMC3148781

3. Hod T, Cerdeira AS and Karumanchi SA. 2015. Molecular Mechanisms of Preeclampsia. Cold Spring Harbor Perspect. Med. 5:a023473.

4. Levine RJ, Lam C, Qian C, Yu KF, Maynard SE, Sachs BP, Sibai BM, Epstein FH, Romero R, Thadhani R, Karumanchi SA and Group CS. 2006. Soluble Endoglin and other Circulating Antiangiogenic Factors in Preeclampsia. N. Engl. J. Med. 355:992–1005. https://doi.org/10.1056/NEJMoa055352; PMid:16957146

5. Vaisbuch E, Whitty JE, Hassan SS, Romero R, Kusanovic JP, Cotton DB, Sorokin Y and Karumanchi SA. 2011. Circulating Angiogenic and Antiangiogenic Factors in Women with Eclampsia. Am. J. Obstetrics Gynecol. 204:152 e1–e9.

6. Venkatesha S, Toporsian M, Lam C, Hanai J, Mammoto T, Kim YM, Bdolah Y, Lim KH, Yuan HT, Libermann TA, Stillman IE, Roberts D, D’Amore PA, Epstein FH, Sellke FW, Romero R, Sukhatme VP, Letarte M and Karumanchi SA. 2006. Soluble Endoglin Contributes to the Pathogenesis of Preeclampsia. Nat. Med. 12:642–649. https://doi.org/10.1038/nm0706-862c; https://doi.org/10.1038/nm1429; PMid:16751767

7. Roberts JM and Hubel CA. 2004. Oxidative Stress in Preeclampsia. Am. J. Obstetrics Gynecol. 190:1177–1178. https://doi.org/10.1016/j.ajog.2004.04.001; PMid:15167813

8. Sheehan HL and Lynch JB. 1973. Pathology of Toxaemia of Pregnancy. Williams and Wilkins Company, Baltimore.

9. Menendez C, Romagosa C, Ismail MR, Carrilho C, Saute F, Osman N, Machungo F, Bardaji A, Quinto L, Mayor A, Naniche D, Dobano C, Alonso PL and Ordi J. 2008. An Autopsy Study of Maternal Mortality in Mozambique: The Contribution of Infectious Diseases, PLoS Med. 5:e44. https://doi.org/10.1371/journal.pmed.0050044; PMid:18288887 PMCid:PMC2245982

10. Hecht JL, Zsengeller ZK, Spiel M, Karumanchi SA and Rosen S. 2016. Revisiting Decidual Vasculopathy. Placenta 42:37–43. https://doi.org/10.1016/j.placenta.2016.04.006; PMid:27238712

11. Schwartz RB, Feske SK, Polak JF, DeGirolami U, Iaia A, Beckner KM, Bravo SM, Klufas RA, Chai RY and Repke JT. 2000. Preeclampsia-Eclampsia: Clinical and Neuroradiographic Correlates and Insights into the Pathogenesis of Hypertensive Encephalopathy. Radiology 217:371–376. https://doi.org/10.1148/radiology.217.2.r00nv44371; PMid:11058630

12. Stillman IE and Karumanchi SA. 2007. The Glomerular Injury of Preeclampsia, J. Am. Soc. Nephrol.: JASN. 18:2281–2284. https://doi.org/10.1681/ASN.2007020255; PMid:17634433

13. Antia FP, Bharadwaj TP, Watsa MC and Master J. 1958. Liver in Normal Pregnancy, Preeclampsia and Eclampsia, Lancet. 2:776–778. https://doi.org/10.1016/S0140-6736(58)91481-8

14. Tsokos M, Longauer F, Kardosova V, Gavel A, Anders S, and Schulz F. 2002. Maternal Death in Pregnancy from HELLP Syndrome. A Report of Three Medico-Legal Autopsy Cases with Special Reference to Distinctive Histopathological Alterations, Int. J. Legal Med. 116:50–53. https://doi.org/10.1007/s00414-001-0276-5; PMid:11924711

15. Long RG, Scheuer PJ and Sherlock S. 1977. Pre-Eclampsia Presenting with Deep Jaundice. J. Clin. Pathol. 30:212–215. https://doi.org/10.1136/jcp.30.3.212

16. Maynard SE, Min JY, Merchan J, Lim KH, Li J, Mondal S, Libermann TA, Morgan JP, Sellke FW, Stillman IE, Epstein FH, Sukhatme VP and Karumanchi SA. 2003. Excess Placental Soluble Fms-Like Tyrosine Kinase 1 (sFlt1) May Contribute to Endothelial Dysfunction, Hypertension, and Proteinuria in Preeclampsia. J. Clin. Invest. 111:649–658. https://doi.org/10.1172/JCI17189; PMid:12618519 PMCid:PMC151901

17. McCarthy FP, Kingdom JC, Kenny LC and Walsh SK. 2011. Animal Models of Preeclampsia. Uses and Limitations. Placenta. 32:413–419. https://doi.org/10.1016/j.placenta.2011.03.010; PMid:21497901

18. Mahasreshti PJ, Kataram M, Wang MH, Stockard CR, Grizzle WE, Carey D, Siegal GP, Haisma HJ, Alvarez RD and Curiel DT. 2003. Intravenous Delivery of Adenovirus-Mediated Soluble FLT-1 Results in Liver Toxicity, Clin. Cancer Res.: Off. J. Am. Assoc. Cancer Res. 9:2701–2710.

19. Abildgaard U and Heimdal K. 2013. Pathogenesis of the Syndrome of Hemolysis, Elevated Liver Enzymes, and Low Platelet Count (HELLP): A Review, Eur. J. Obstet. Gynecol. Reprod. Biol. 166:117–123. https://doi.org/10.1016/j.ejogrb.2012.09.026; PMid:23107053

20. Govan AD. 1976. The Histology of Eclamptic Lesions. J. Clin. Pathol. Suppl. 10:63–69. https://doi.org/10.1136/jcp.29.Suppl_10.63; https://doi.org/10.1136/jcp.s3-10.1.63

21. Iwakiri Y, Shah V, and Rockey DC. 2014. Vascular Pathobiology in Chronic Liver Disease and Cirrhosis – Current Status and Future Directions. J. Hepatol. 61:912–924. https://doi.org/10.1016/j.jhep.2014.05.047; PMid:24911462 PMCid:PMC4346093

22. Lazarus A and Keshet E. 2011. Vascular Endothelial Growth Factor and Vascular Homeostasis, Proc. Am. Thoracic Soc. 8:508–511. https://doi.org/10.1513/pats.201102-021MW; PMid:22052928

23. Maharaj AS, Walshe TE, Saint-Geniez M, Venkatesha S, Maldonado AE, Himes NC, Matharu KS, Karumanchi SA, and D’Amore PA. 2008. VEGF and TGF-beta are Required for the Maintenance of the Choroid Plexus and Ependyma, J. Exp. Med. 205:491–501. https://doi.org/10.1084/jem.20072041; PMid:18268040 PMCid:PMC2271023

24. Brown LF, Berse B, Tognazzi K, Manseau EJ, Van de Water L, Senger DR, Dvorak HF, and Rosen S. 1992. Vascular Permeability Factor mRNA and Protein Expression in Human Kidney, Kidney Int. 42:1457–1461. https://doi.org/10.1038/ki.1992.441; PMid:1474780