• Molecular and biological genetic inductors of change mucous endometrium at external genital endometriosis

Molecular and biological genetic inductors of change mucous endometrium at external genital endometriosis

HEALTH OF WOMAN. 2017.3(119):103–109

Veropotvelyan P. N., Tsehmistrenko I. S., Bondarenko A. A., Osadchuk E. G., Zhuravleva S. A. 
Interregional Center of Medical Genetics and Prenatal Diagnosis, Krivoy Rog
Perinatal Center, Kiev
Center for Family Planning and Human Reproduction, Krivoy Rog

The main theories of the pathogenesis of endometriosis are described. A modern approach is presented concerning the eutopic endometrium of patients with endometriosis and endometrioid heterotopia, including changes in the expression of inducers of adhesion, invasion, angiogenesis, hormonal inducers, receptivity and inducers of immunity.

Differences in healthy endometrium, endometrium of patients with endometriosis and endometrioid heterotopia have been determined. These studies contribute to increasing knowledge of the pathogenesis of endometriosis, the timely identification of possible therapeutic targets and, in addition, realize the effectiveness of methods for early diagnosis and prediction of the course of this pathology.

Key words: endometriosis, ectopic endometrium, hormonal inducers, eutopic endometrium, receptivity.


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