• Metabolic immunomodulation: polyunsaturated fatty acids for the prevention of acute respiratory pathology in children

Metabolic immunomodulation: polyunsaturated fatty acids for the prevention of acute respiratory pathology in children

SOVREMENNAYA PEDIATRIYA.2017.1(81):64-73; doi 10.15574/SP.2017.81.64

Ovcharenko L. S., Slutskaya T. V., Vertegel A. A., Andrienko T. G., Samokhin I. V., Kriazhev A. V.
State Institution «Zaporizhzhia Medical Academy of Postgraduate Education of the Ministry of Health of Ukraine»

The aim of the research was to increase the effectiveness of the prevention of acute respiratory infections (ARI) in children with chronic foci of bacterial infection in the nasopharynx. 60 children aged 3 to 5 years who are ill with ARI six or more times a year were under supervision. For the prevention of acute respiratory infections in the period of increased morbidity 30 children of the 1st group for 60 days have been taking the drug Reytoil 1 capsule per day during meals, 30 children of the 2nd group have been taking multivitamins in a prophylactic daily dose. The groups were comparable in age, sex, duration and severity of the disease, concomitant pathology. The state of immunity was studied by conventional methods in dynamics for 90±10 days. Practical use of w-3 polyunsaturated fatty acids in the drug Reytoil allows solving important tactical and strategic tasks of therapy and prevention of inflammatory diseases of various genesis in children, which is associated with the universal regulatory mechanism of immunotropic influence – protective and anti-inflammatory, depending on the initial state of the immune activity. These effects open real prospects for safe immunomodulating effects in pediatric practice through metabolic mechanisms of the regulation of the synthesis and functioning of immunocompetent cellular structures.

Key words: children, polyunsaturated fatty acids, immunity, prevention.

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