- Корекція Psycho-emotional disorders and stress conditions correction in children with functional gastrointestinal disorders
Корекція Psycho-emotional disorders and stress conditions correction in children with functional gastrointestinal disorders
SOVREMENNAYA PEDIATRIYA.2017.2(82):76-84; doi 10.15574/SP.2017.82.76
Berezhniy V., Mamenko M., Drokh H., Boyarska K., Kozhyna H., Boholey O., Horbatova L.
Shupyk National Medical Academy of Postgraduate Education, Kyiv, Ukraine
Kyiv City Children's Clinical Hospital No. 1, Ukraine
И to evaluate the efficacy and safety of γ-phenyl-β-aminobutyric acid in treatment of functional dyspepsia (FD) in primary school children.
Materials and methods. The study involved 80 children aged 6-12 years with FD. Children were distributed into two groups: the main group — 40 patients, who received basic therapy along with γ-phenyl-β-aminobutyric acid (Noophen®100) and control group — 40 children who received only basic scheme of treatment. Methods of examination: clinical, instrumental, psychological testing, ELISA (adrenocorticotropic hormone (ACTH), cortisol, norepinephrine in blood serum and urine, insulin), biochemical markers (glucose, bilirubin, ALT, AST), statistics.
Results. Children with FD demonstrated clinical performance of autonomic dysfunction complaints (93%), high levels of depression (42%), anxiety (61%), sleep disorders (85%), reduced cognitive function (86%). High levels of stress condition were manifested by the increased levels of cortisol (597.6 nmol/L), norepinephrine in plasma (14.3 pg/ml) and in urine (111.4 mcg/day), high glucose levels (5.1 mmol/ml) and relatively low content of insulin (8.2 mcMO/ml) and ACTH (15.8 pg/mL). After the treatment with γ-phenyl-β-aminobutyric acid it was detected a significant decrease of FD symptoms (p=0.017), decreased levels of anxiety (p=0.050) and depression (p=0.033), lower manifestations of autonomic disorders (p=0.003), rare sleep disturbances (p=0.023), improved attention (p=0.041) and memory (p=0.007). Reduction of sympathoadrenal system activity was detected that was demonstrated by lower levels of cortisol (p=0.031), norepinephrine in urine (p=0.037) and plasma (p=0.041), higher levels of ACTH (p=0.042).
Conclusions. The γ-phenyl-β-aminobutyric acid usage in treatment of functional dyspepsia (FD) in primary school children may be recommended as effective and safe method.
Key words: functional gastrointestinal disorders, functional dyspepsia, stress, treatment.
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