• Genetic aspects of multiple pregnancy (clinical lecture)

Genetic aspects of multiple pregnancy (clinical lecture)

HEALTH OF WOMAN.2017.2(118):11–16; doi 10.15574/HW.2017.118.11

Nazarenko L. G., Belyaev S. G.
Kharkiv medical Academy of postgraduate education

The article focuses on the main aspects of multiple pregnancies, filed with the position of medical genetics. Presented the terminology, classification, mechanism of development of certain types of multiple pregnancies, the issues of foresighting. Separately considered the main pathological condition typical for monozygotic multiple pregnancy that are interesting to the practical obstetrician-gynecologists.

Key words: multiple pregnancy, identical twins, no identical twins, imprinting, mosaicism, chromosome zygote, egg.


1. Latypov AS. 2015. Genetic aspects of prenatal diagnosis of fetal chromosomal abnormalities in women during pregnancy after in vitro fertilization (dissertation). M:164.

2. Bochkov NP, Bochkovski K, Bukkovich J. 1970. Problems of medical genetics. M, Medicine:559.

3. Topchiy ME. 2009. Prevention of recurrent miscarriage and preterm labor in multiple pregnancy (dissertation). K:21.

4. Filippova NA. 2009. The value of prenatal ultrasound in assessing the nature of growth of fetuses in multiple pregnancies (dissertation). Novgorod:25.

5. Fuks MA. 1990. Multiple pregnancy. Kyiv, Zdorovia:6-12.

6. Lamb DJ, Middeldorp CM, van Beijsterveldt CE et al. 2011. Birth weight in a large series of triplets. BMC Pediatr. 11:24. https://doi.org/10.1186/1471-2431-11-24; PMid:21453554 PMCid:PMC3087677

7. Oberg S, Cnattingius S, Sandin S, Lichtenstein P, Iliadou AN. 2011, Jun 21. Birth weight predicts risk of cardiovascular disease within dizygotic but not monozygotic twin pairs: a large population-based co-twin-control study. Circulation. 123(24):2792-27988. https://doi.org/10.1161/CIRCULATIONAHA.110.987339; PMid:21632494

8. Sarais V, Paffoni A, Baffero GM, Parazzini F, Persico N, Somigliana E. 2016, Feb. Estimating the Risk of Monochorionic Twins in IVF Pregnancies From the Perspective of a Prenatal Diagnosis Unit. Twin Res Hum Genet. 19(1):66-71. https://doi.org/10.1017/thg.2015.94; PMid:26690084

9. Bieber FR, Nance WE, Morton CC, Brown JA, Redwine FO, Jordan RL et al. 1981, Aug 14. Genetic studies of an acardiac monster: evidence of polar body twinning in man. T.Science. 213(4509):775-777. https://doi.org/10.1126/science.7196086; PMid:7196086

10. Goldgar DE, Kimberling WJ. 1981. Genetic expectations of polar body twinning. Acta Genet Med Gemellol (Roma). 30(4):257-266. https://doi.org/10.1017/S0001566000006462

11. Saravelos SH, Zhang T, Chung JP, Sun LM, Sun Y, Li TC et al. 2016, Jan. Monochorionic quadramniotic and triamniotic pregnancies following single embryo transfers: two case reports and a review of the literature. J Assist Reprod Genet. 33(1):27-32. https://doi.org/10.1007/s10815-015-0611-2; PMid:26564016 PMCid:PMC4717140

12. Macatangga M, De la Calle M, Torres ML, Bartha JL. 2016, Mar-Apr. Monozygotic Monochorionic Twins Discordant for Trisomy 21: A Reason to Evaluate Both Fetuses: A Case Report. J Reprod Med. 61(3-4):167-170. PMid:27172641

13. Montreal QC. 2011. Prenatal screening for and diagnosis of aneuploidy in twin pregnancies. J. Obstet. Gynaecol. Can. 33;7:754–767. https://doi.org/10.1016/S1701-2163(16)34963-5

14. Boubkraoui M, Aguenaou H, Mrabet M, Barkat A. 2016 Mar 10. Perinatal morbidity and mortality in twin pregnancies in a Moroccan level-3 maternity ward. A Pan Afr Med J. 23:80. PMCid:PMC4862788

15. Grosen D, Bille C, Petersen I, Skytthe A, Hjelmborg JB, Pedersen JK et al. 2011, May. Risk of oral clefts in twins. Epidemiology 22(3):313-319. https://doi.org/10.1097/EDE.0b013e3182125f9c; PMid:21423016 PMCid:PMC3089024

16. D'Arpe S, Franceschetti S, De Stefano MG, D'Amelio R, Maragno AM et al. 2016. The impact of chorionicity and type of conception on maternal-neonatal outcome in twin pregnancies. P.Clin Exp Obstet Gynecol. 43(1):88-92. PMid:27048024

17. Tagliani-Ribeiro A, Oliveira M, Sassi AK, Rodrigues MR, Zagonel-Oliveira M, Steinman G et al. 2011. Twin Town in South Brazil: a Nazi's experiment or a genetic founder effect? PLoS One. 6(6):e20328. https://doi.org/10.1371/journal.pone.0020328; PMid:21687665 PMCid:PMC3110757

18. Whitfield J. 2007. Semi-identical' twins discovered Hermaphrodite reveals previously unknown type of twinning. Nature (Internet). doi:10.1038/news070326-1. Available from: http://www.nature.com/news/2007/070326/full/news070326-1.html.

19. Silva S, Martins Y, Matias A, Blickstein I. 2011. Why are monozygotic twins different? J. Perinat. Med. 39;2:195–202. https://doi.org/10.1515/jpm.2010.140

Содержание журнала Full text of article