• Food intolerance in the pathogenesis of functional gastrointestinal disorders in infants: approaches to diagnosis and treatment 

Food intolerance in the pathogenesis of functional gastrointestinal disorders in infants: approaches to diagnosis and treatment 

PERINATOLOGIYA I PEDIATRIYA.2016.1(65):104-111;doi 10.15574/PP.2016.65.104 
 

Food intolerance in the pathogenesis of functional gastrointestinal disorders in infants: approaches to diagnosis and treatment 
 

Shadrin O. G., Marushko T. L., Radushinskaya T. Yu., Marushko R. V., Fisun V. N., Kovalchuk A. A., Bondarenko N. Y.

SI «Institute of pediatrics, obstetrics and gynecology NAMS of Ukraine», Kyiv, Ukraine 
 

Purpose — to study the clinical and paraclinical features of gastrointestinal manifestations of food intolerance and improve the efficiency of their treatment. 
 

Patients and methods. Among 147 infants with functional gastrointestinal disorders based on clinical and paraclinical examinations, identified 65 patients with gastrointestinal disorders caused by food intoleranc. Depending on the plan of the treatment, children with food intolerance were divided into two groups — the main group (40 children apart form symptomatic treatment received treatment for the main disease) and control group (25 children who received only symptomatic treatment according to the protocols). 
 

Results. In 44.2% of young children with gastrointestinal disorders was revealed food intolerance (non-allergic food hypersensitivity). Combination of symptomatic treatment (simethicone, prokinetics, spasmolytics, etc.) and treatment of the main disease (depending on the cause of food intolerance — enzymes, cholagogic preparation, probiotics, etc.) in the complex therapy allowed to eleminate or significantly reduce the intensity of clinical manifestations of gastrointestinal disorders in 90% of children of main group. 
 

Conclusions. Gastrointestinal disorders in children with food intolerances are not clinically different from functional gastrointestinal diseases, but are characterized by high intensity, combination of various gastrointestinal disorders, lack of efficiency of symptomatic treatment. To improve the efficiency of treatment in children with secondary gastrointestinal disorders, it is required the timely appropriate diagnostics of food intolerance and the treatment of underlying disease. 
 

Key words: infants, gastrointestinal tract, functional disorders, food intolerance, treatment. 
 

REFERENCES

1. Nagornaya NV, Bordyugova EV, Dubovaya AV, Dudchak AP. 2014. Abdominal pain syndrome in children with lactase deficiency. Sovremennaya pediatriya. 1(57): 106—112. doi 10.15574/SP.2014.57.106

2. Aryaev NL, Kozhevin RV. 2010. Infant intestinal colic: current approaches to treatment. Sovremennaya pediatriya. 5(33): 162—166.

3. Kornienko EA, Vagemans NV, Netrebenko OK. 2010. Infant intestial colics: the modern view about mechanisms of development and new abilities of treatment. Sovremennaya pediatriya. 5(33): 176—183.

4. Luss LV. 2005. Pischevaya allergiya i pischevaya neperenosimost. AllergoKlass: zhivite v mire s allergiey. 2(5): 2—3.

5. Shumilov PV, Dubrovskaya MI, Yudina OV i dr. 2007. Porazheniya zheludochno-kishechnogo trakta u detey s pischevoy allergiey. Trudnyiy patsient. 10: 19—25.

6. Rachkova NS. 2007. Kishechnyie koliki u detey rannego vozrasta: podhodyi k terapii. RMZh. 15; 17: 1—4.

7. Funktsionalnyie zabolevaniya pischevaritelnoy sistemyi u detey. Pod red YuV Belousova, OYu Belousovoy. Harkov, ID «INZhEK», 2005: 256.

8. Kharchuvannia v pediatrii. Za red PK Samur, K Kinh. Lviv, Medytsyna svitu, 2012: 562.

9. Shaposhnikova YuN. 2008. Pischevaya allergiya i pischevaya neperenosimost: sovremennyiy vzglyad na problemu. Suchasna gastroenterologIya. 4(42): 90—101.

10. Pasqui F, Poli C, Colecchia A et al. 2015. Adverse Food Reaction and Functional Gastrointestinal Disorders: Role of the Dietetic. Approach J Gastrointestin Liver Dis. 24; 3: 319-327. PMid:26405704

11. American College of Allergy, Asthma, Immunology. Food allergy: a practice parameter. Ann Allergy Asthma Immunol. 2006. 96; 3 Suppl 2: S1—S68. http://dx.doi.org/10.1016/S1081-1206(10)60926-X

12.Ammoury R, Croffie J. 2010. Malabsorptive Disorders of Childhood. Pediatrics in Review. 31; 10: 407—416. http://dx.doi.org/10.1542/pir.31-10-407

13. Cantani A. 2006. Benefits and concerns associated with biotechnology-derived foods: can additional research reduce children healthrisks? Eur Rev Med Pharmacol Sci. 10(4): 197—206. PMid:16910351

14. Carlson MJ, Moore CE, Tsai CM et al. 2014. Child and parent perceived food-induced gastrointestinal symptoms and quality of life in children with functional gastrointestinal disorders. J Acad Nutr Diet. 114: 403—413. http://dx.doi.org/10.1016/j.jand.2013.10.013; PMid:24360501 PMCid:PMC4267718

15. Dreskin SC. 2006. Genetics of food allergy. Curr Allergy Asthma Rep. 6(1): 58—64. http://dx.doi.org/10.1007/s11882-006-0012-9; PMid:16476197

16. Fiocchi A, Assa'ad A, Bahna S. 2006. Food allergy and the introduction of solid foods to infants: a consensus document. Adverse Reactions to Foods Committee, American College of Allergy, Asthma and Immunology. Ann Allergy Asthma Immunol. 97(1): 10—20. http://dx.doi.org/10.1016/S1081-1206(10)61364-6

17. Roehr CC, Edenharter G, Reimann S et al. 2004. Food allergy and non allergic food hypersensitivity in children and adolescents. Clin Exp Allergy. 34(10): 1534—1541. http://dx.doi.org/10.1111/j.1365-2222.2004.02080.x; PMid:15479267

18. Hill RJ. 2014. The role of food intolerance in functional gastrointestinal disorders in children. Reprinted from Australian Family Physician. 43; 10: 686—689.

19. Kurowski K, Boxer WR. 2008. Food allergies: detection and management. Am Fam Physician. 77(12): 1678—1686. PMid:18619076

20. Leung A, Lemau J. 2004. Infantile colic: a review. J R Soc Health. 124(4): 162—180. http://dx.doi.org/10.1177/146642400412400407

21.Moneret-Bautrin DA, Morisset M. 2005. Adult food allergy. Curr Allergy Asthma Rep. 5(1): 80—85. http://dx.doi.org/10.1007/s11882-005-0060-6

22. Wake M, Morton-Allen E, Poulakis Z et al. 2006. Prevalence, stability and outcome of cry-fuss and sleep problems in the first 2 years of life: a community-based study. Pediatrics. 117: 836—842. http://dx.doi.org/10.1542/peds.2005-0775; PMid:16510665

23. Von Kries R, Kalies E, Papousek M. 2006. Excessive crying beyond 3 months herald other features of multiple regulatory problems. Arch Pediatr Adolesc Med. 160: 508—511. http://dx.doi.org/10.1001/archpedi.160.5.508; PMid:16651494

24. Wolke D, Rizzo P, Woods S. 2002. Persistent infant crying and hyperactivity problems in middle childhood. Pediatrics. 109: 1054—1060. http://dx.doi.org/10.1542/peds.109.6.1054; PMid:12042542