• On Feasibility of Adapted Goat Infant Milk Formula Usage in Newborns with Perinatal Pathology

On Feasibility of Adapted Goat Infant Milk Formula Usage in Newborns with Perinatal Pathology

SOVREMENNAYA PEDIATRIYA.2017.4(84):91-94; doi 10.15574/SP.2017.84.91

Klymenko T. M., Serdtseva O. A., Karatai O. S., Melnychuk O. P.
Kharkiv Medical Academy of Postgraduate Education, Ukraine
Kharkiv City Perinatal Centre, Ukraine

Retionale. Nutrition of newborns with perinatal pathology is an issue of discussion among scientists and clinicians according to the impact of malnutrition and some micronutrients deficiency on the development of brain structures, the mental development and the formation of behavioral reactions. The issue of ingredient composition of milk formula is still unsolved and requires the additional research. The breast milk is undoubtedly the best food for a child's harmonious development. However, in some cases breastfeeding is not possible due to objective reasons. The main of them are the impossibility of breastfeeding and milk protein intolerance. Therefore, today the physicians gain an experience of the goat milk formula using in infants feeding. The goat milk formula Kabrita® Gold 1 is considered efficacious. It is the most balanced substitute of breast milk, based on the goat milk and consists of the whey formula. In its casein ratio dominates β-casein. Thanks to the presence of αs1-casein determining the level of protein coagulation, the goat's milk protein forms a soft, easily digestible bolus in stomach, like a bolus of breast milk protein. The formula contains alpha-lactalbumin, 1.5 g/100 ml protein and has small sized fat globules. The fat component of formula includes the lipid complex DigestX with the high content of palmitic acid in the sn-2 position (42%) of glycerol molecule as well as the breast milk. This complex improves the absorption of fat and calcium by reducing the fecal excretion of fatty acids and calcium. There are prebiotics, galacto- and fructo-oligosaccharides, bifidobacterium ВВ12, nucleotides, long chain polyunsaturated fatty acids, vitamins, macro- and micronutrients in this formula.

Objective — to evaluate the clinical efficacy of milk formula Kabrita® Gold 1 as the main feeding of full-term newborns with perinatal pathology.

Materials and methods. The clinical status of 30 full-term newborns without functional nutrition disorders was analyzed. All neonates were fed with the infant goat milk formula Kabrita® Gold 1 (the 1st group). There were 21 (70.0%) infants with intrauterine pneumonia, 7 (23.3%) neonates with mild intrauterine growth retardation, 5 (16.7%) newborns with mild hypoxic-ischemic CNS injury, 6 (20.0%) infants with congenital vesiculopustulosis among them. The course of milk formula administration for each baby was from 10 days to 3 weeks. The clinical-laboratory assessment of tolerance of the formula, such as the dynamics of body weight, the data of coprogram and clinical urine analysis, the intestine microbiological status, and the dynamics of biochemical indicators were daily performed in newborns. For monitoring the same criteria, 20 newborns (the 2nd group) were fed with a cow milk infant formula.

Results. The newborns' adaptation period to the new formula Kabrita® Gold 1 passed satisfactorily. The newborns had not refused from meal. The time gap between feedings was stable. The allergic reactions were noted in two children (6.7%) of the 1st group and in one child (5.0%) of the 2nd group with a gradual symptom reduction at time of hospital discharge. There were eosinophilia more than 5% in the blood cell count in two (or 6.6%) children of the 1st group and in two (10.0%) neonates of the 2nd group. The gastrointestinal disturbances in form of the severe flatulence were observed in 5 children (16.7%) of the 1st group and in 4 neonates (20.0%) of the 2nd group. Thus, the post-meal symptom intensity decreased at the second week of the formula using while its volume increased in 1.3 times. Significant violations of children's stool consistency were not observed. Prior to our investigation 8 newborns (26.8%) of the 1st group and 5 children (25.0%) of the 2nd group had regurgitation, the manifestation of which were reversed at the 2nd week of feeding in children of the 1st group. The results of biochemical analysis and clinical urine analysis in newborns were within normal limits. The results of stool tests showed the improvement of absorption. Analysis of the intestinal microflora showed that the average number of microorganisms on the 10–12th and 20–25th days was the same as in the 2nd group children, such as bifidobacteria 7.0 Lg CFU/g and 8.0–9.0 Lg CFU/g; lactic bacteria 6.0 Lg CFU/g and 7.0 Lg CFU/g respectively.

Conclusions. The goat milk formula Kabrita® Gold 1 with well-balanced macronutrients and micronutrients composition, and lots of essential nutritional factors, can be considered as an alternative to the modern cow milk infant formulas and the nutrition of newborns with perinatal pathology.

Key words: nutrition, newborns, perinatal pathology.

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