• Epidermal growth factor and prolonged neonatal jaundice 

Epidermal growth factor and prolonged neonatal jaundice 

PERINATOLOGIYA I PEDIATRIYA. 2016.4(68):60-62; doi 10.15574/PP.2016.68.60 
 

Epidermal growth factor and prolonged neonatal jaundice 
 

Yablon O., Mazur O.

Vinnytsya National Pirogov Memorial Medical University, Ukraine


Purpose — to determine content of serum epidermal growth factor in newborns with prolonged jaundiceand its influence on the duration of hyperbilirubinemia.


Patients and methods. The study included 50 children who were treated at the Vynnytsia regional children's hospital about prolonged jaundice in newborns, among them 27 boys and 23 girls. The comparison group consisted of 12 children with physiological jaundice — 7 boys and 5 girls. All children were breastfed.


Results. All children were full term, the mean gestational age for the main group of children was 39±0.14 weeks, the comparison group was 39±0.25 weeks (p>0.05). In the biochemical analysis of blood in children of the main group and the comparison group there was an increase in the level of total bilirubin in blood serum due to its indirect fraction: mean levels of total bilirubin in blood serum in children of the main group amounted to 280.96±10 μmol/l; in comparison group, mean levels of total bilirubin in blood serum was significantly lower — 184.7±6.8 μmol/l (p<0.05). Serum levels of EGF in children of the main group were increased in 2 times than the comparison group 393.9 [241–572] ng/ml and of 188.8 [76.3–243] ng/ml (p<0.05). The analysis of the levels of serum EGF in children depending on the duration of jaundice. So, in children with duration of jaundice of more than 1 month levels of serum EGF were 59% higher in comparison with children with the duration of jaundice in less than 1 month, respectively, to 494.6±49.7 ng/ml and 355.8±39.7 ng/ml (p<0.05).


Conclusions. In children with prolonged neonatal jaundice the levels of serum epidermal growth factor were 393.9 [241–572] ng/ml, which is 2 times higher than in children with physiological jaundice. It was determined the dependency of the rate of epidermal growth factor on the duration of jaundice: the highest levels were observed in children with duration of jaundice more than 1 month.


Key words: prolonged jaundice, epidermal growth factor, bilirubin, newborns.


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