• Dynamic indicators of the airway inflammation activity in teenagers with bronchial asthma

Dynamic indicators of the airway inflammation activity in teenagers with bronchial asthma

SOVREMENNAYA PEDIATRIYA.2017.2(82):102-105; doi 10.15574/SP.2017.82.102

Koloskova O. K., Shahova O. O, Tarnavska S. I., Shevchenko N. O.
Higher State Educational Establishment of Ukraine «Bukovinian State Medical University», Chernivtsi, Ukraine

Objective: to evaluate the activity indices of airway inflammation in adolescents with bronchial asthma (BA) in post exacerbation period to optimize individualized treatment and prevention tactics.

Material and methods. In total 42 adolescents with BA in post exacerbation period were examined. Activity airway inflammation was studied on the grounds of the exhaled breath condensate content, which included the determination of total protein, metabolites of nitrogen monoxide, proteolytic activity by lysis azoalbumin, azokasein and azoсollagen.

Results and conclusions. The markers of bronchi inflammation in adolescents in post exacerbation period of BA was found, as well as the fading of such interconnected with inflammation processes as leakage of protein from vessels, proteolysis and fibrinolysis activity without a significant relationship between these processes. These changes can lead to increased nonspecific bronchial hypersensitivity to the direct and indirect incentives as a reflection of the local inflammatory response of respiratory tract.

Key words: asthma, adolescents, exhaled breath condensate, inflammation of bronchi.


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