• Defining the role of leading genetic and clinical factors in the development of miscarriage 

Defining the role of leading genetic and clinical factors in the development of miscarriage 

PERINATOLOGIYA I PEDIATRIYA. 2016.4(68):42-46; doi 10.15574/PP.2016.68.42 
 

Defining the role of leading genetic and clinical factors in the development of miscarriage 
 

Vorobyova І., Skrypchenko N., Tkachenko V., Rudakova N., Zhyvetskaya—Denisova A., Tolkach S.

SI «Institute of Pediatrics, Obstetrics and Gynecology of NAMS of Ukraine», Kyiv


Purpose — to determine a polymorphism of candidate genes miscarriage system allows improving measures to prevent it.


Patients and methods. The paper used clinical, genetic, biochemical, endocrinological, ultrasonic, statistical methods.


Results. Statistical analysis of hypotheses on the distribution of allelic variants of unfavourable polymorphisms studied genes (indicators) in groups of women with recurrent pregnancy and in the control group showed that they differ from uniform. Also has two most frequent combination of allelic polymorphism candidate genes in women with miscarriage.


Conclusions. The study formed the modern concept (causation) of miscarriage. On this basis a system of prevention and treatment of women with miscarriage before and during pregnancy. Its effectiveness is confirmed perinatal outcomes in risk groups miscarriage.


Key words: polymorphism of genes, development of miscarriage.


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