- Comparative analysis of clinic-epidemiological profile of 2009 and 2016 pandemic influenza А/ (H1N1) in hospitalized children of Zaporozhye region
Comparative analysis of clinic-epidemiological profile of 2009 and 2016 pandemic influenza А/ (H1N1) in hospitalized children of Zaporozhye region
SOVREMENNAYA PEDIATRIYA.2017.2(82):47-51; doi 10.15574/SP.2017.82.47
Konakova O. V., Ysachova O. V., Silina E. A., Pakholchuk T. M., Dralova O. A., Ivanova I. B.
Zaporozhye State Medical University, Ukraine
Municipal institution «Regional Infectious Diseases Hospital» of Zaporizhzhya Regional Council, Ukraine
Objective: to study clinical and epidemiological characteristics of clinical course in patients with pandemic influenza А/ (H1N1) during the 2009 and 2016 seasons in the hospitalized children of Zaporizhzhya regional infectious disease hospital.
Material and methods. Retrospective analysis of 169 medical records was conducted, among them 116 patients were hospitalized during December 2009 pandemic A/H1N1 (index group) and 53 ones were admitted in January 2016/ H1N1 (comparison group).
Results. Children aged from 12 to 17 years during 2009 A/H1N1 influenza pandemic made up 52.6 %, however, in 2016 patients ranged in age from 3 to 6 years prevailed that worked out 56.6 % (p=0.001). The burdened premorbid background determined in 22 patients (18.9 %) of index group versus eight patients (15.1 %) of comparison group. In 99.1 % of patients of 2009 H1N1 influenza pandemic and 98.1 % of 2016 pandemic diagnosed the moderately grave condition. The mean value of temperature peak in the index group was 39.2±0.7°С compared to 39.5±0.6°С in the comparison group. The respiratory syndrome occurred in 82.6 % of events of 2009 H1N1 influenza pandemic by contrast with 71.7 % of 2016 one. The clinical signs of gastroenteropathy observed in 22 patients (19 %) of the index group compared with eight cases (15.2 %) in the group of comparison. The febrile seizures more often occurred in the patients of 2016 pandemic H1N1 influenza (5.7% versus 1.7% of index group). In both groups, pneumonia prevailed as complication, which made up 4.3 % of children in the index group and 3.8 % in the comparison group.
Conclusions. Among the hospitalized children with influenza A/H1N1 during the 2009 epidemic season prevailed adolescents, however, in 2016 the majority of children was preschool-aged. The clinical course of influenza A/H1N1 was moderate in the majority of patients. Among complications pneumonia dominated in both groups, while febrile seizures prevailed in 2016.
Key words: influenza, H1N1, children, clinical signs, complications.
1. Bentsa TM. 2011. Acute respiratory viral diseases: modern tendency of treatment and prophilaxis. Simeina medytsyna. 1: 25-29.
2. Data of the Center influenza and ARVI of state institution “Ukrainian center of control and monitoring of Ministry of Health in Ukraine. http://www.moz.gov.ua/.
3. Malyi VP, Holobova OV. 2011. Antiviral therapy of patients with influenza. Klinichna imynolohiia. Alerholohiia. Infektolohiia. 4(43): 53-56.
4. Kramaryov SO, Ievtyshenko VV, Vyhovska AV. 2016. Characteristic of influenza in the season 2016 in children. Aktyalnaya infektolpgiya. 1(10): 25-29.
5. Kumar S., Havens PL, Chusid MJ et al. 2010. Clinical and epidemiologic characteristic children hospitalized with 2009 pandemic H1N1 influenza A infection. Pediat Infect Dis J. 29; 7: 591-594. https://doi.org/10.1097/INF.0b013e3181d73e32; PMid:20589976
6. Heininger U, Baer G, Ryser A-J et al. 2013. Comparative analysis of clinical characteristics of pandemic influenza A/H1N1 and seasonal influenza infections in hospitalized children. Pediat Infect Dis J. 32; 3: 293-296. PMid:23190773
7. Sivennoinen H, Huusko T, Vuorinen T et al. 2015. Comparative Burden of influenza A/H1N1, A/H2N3 and B infections in children treated as outpatients. Pediat Infect Dis J. 34; 10: 1081-1085. https://doi.org/10.1097/INF.0000000000000814; PMid:26181897